CAS Number548-04-9
SynonymsEINECS 208-941-0; 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione; CYCLOSAN; Hypericin; MYCOPORPHYRIN; HYPERICUM RED; VIMRxyn; 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone; MYCOPOPHYRIN; CYCLO-WERROL; MFCD02100619
Molecular FormulaC30H16O8
Molecular Weight504.44
Purity~95 (HPLC)%
Density1.9±0.1 g/cm3
Boiling Point930.1±65.0 °C at 760 mmHg
Melting Point299-301°C
Appearancered
EINECS208-941-0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 548-04-9 |
| Catalog No. | 2A-9022811 |
| Chinese Name | 金丝桃素 |
| Synonyms | EINECS 208-941-0; 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione; CYCLOSAN; Hypericin; MYCOPORPHYRIN; HYPERICUM RED; VIMRxyn; 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone; MYCOPOPHYRIN; CYCLO-WERROL; MFCD02100619 |
| Molecular Formula | C30H16O8 |
| Molecular Weight | 504.44 |
| Purity | ~95 (HPLC) |
| Density | 1.9±0.1 g/cm3 |
| Boiling Point | 930.1±65.0 °C at 760 mmHg |
| Melting Point | 299-301°C |
| Appearance | red |
| Water Solubility | 1 M NaOH: 10 mg/mL |
| Storage Condition | Store in a cool, dry, well-ventilated warehouse, p |
| Application | Hypericin is an extract of Hypericum perforatum and has anti-cancer and anti-depression photosensitive antiviral properties. |
| EINECS | 208-941-0 |
| HTC | 2914700090 |
| PubChem ID | 57651594 |
| MDL Number | MFCD00016683 |
| SMILES | Cc1cc(O)c2C(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6C(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c56 |
| InChI | 1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3 |
| InChI Key | BTXNYTINYBABQR-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1917913 |
| NACRES Code | NA.77 |
| UNSPSC | 51101500 |
| MSDS | msds/22811_1_548_04_9.pdf |
| Use of | Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM. IC50: 7.5 uMIn vitro:The photosensitive of hypericin can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion. PDT with hypericin results in the activation of multiple pathways that can either promote or counteract the cell death program. It can effect cytotoxic to tumor cells by visible light. Properties Articles71 Name hypericin Synonym More Synonyms Hypericin Biological Activity Description Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM. IC50: 7.5 uMIn vitro:The photosensitive of hypericin can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion. PDT with hypericin results in the activation of multiple pathways that can either promote or counteract the cell death program. It can effect cytotoxic to tumor cells by visible light. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Others Research Areas >> Others References [1]. Agostinis P et al. Hypericin in cancer treatment: more light on the way. Int J Biochem Cell Biol. 2002 Mar;34(3):221-41. [2]. Lenard J et al. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses usinghypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):158-62. [3]. Hwang MS et al. Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin. Anticancer Res. 2001 Jul-Aug;21(4A):2649-55. Chemical & Physical Properties Molecular Formula C30H16O8 Exact Mass 504.084503 PSA 155.52000 Index of Refraction 2.131 InChIKey YDOIFHVUBCIUHF-UHFFFAOYSA-N Safety Information Signal Word Warning Hazard Statements H302-H317 Precautionary Statements P280-P301 + P312 + P330 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xn:Harmful Risk Phrases R22 Safety Phrases S22-S36 RIDADR 2811 WGK Germany 3 HS Code 2914700090 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0% |
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