CAS Number529-59-9
Synonyms7-(b-D-Glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Genisteol 7-monoglucoside; Genistin; 5-Hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-β-D-glucopyranoside; 4',5,7-trihydroxyisoflavone-7-D-glucoside; Diadzin; MFCD00016883; 4',5,7-Trihydroxyisoflavone 7-glucoside; GLUCOSYL-7-GENISTEIN; Genistein-7-glucoside; genistein 7-O-beta-D-glucoside; Genistein 7-O-β-D-glucoside; Genistein, 7-O-β-D-glucoside; genistein 7-O-glucoside; 5-Hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl β-D-glucopyranoside; Genistein 7-O-b-D-Glucoside; Soybean Extract; Genistein-7-O-β-D-glucopyranoside; Genistine; Genistein glucoside; Genistoside; Genistein, 7-β-D-glucopyranoside; Genistein-7-O-glucoside; Genistein 7-glucoside
Molecular FormulaC21H20O10
Molecular Weight432.38
Purity≥95 (HPLC)%
Density1.6±0.1 g/cm3
Boiling Point788.9±60.0 °C at 760 mmHg
Melting Point254ºC
Appearancecolorless crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 529-59-9 |
| Catalog No. | 2A-9022548 |
| Chinese Name | 染料木苷 |
| Synonyms | 7-(b-D-Glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Genisteol 7-monoglucoside; Genistin; 5-Hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-β-D-glucopyranoside; 4',5,7-trihydroxyisoflavone-7-D-glucoside; Diadzin; MFCD00016883; 4',5,7-Trihydroxyisoflavone 7-glucoside; GLUCOSYL-7-GENISTEIN; Genistein-7-glucoside; genistein 7-O-beta-D-glucoside; Genistein 7-O-β-D-glucoside; Genistein, 7-O-β-D-glucoside; genistein 7-O-glucoside; 5-Hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl β-D-glucopyranoside; Genistein 7-O-b-D-Glucoside; Soybean Extract; Genistein-7-O-β-D-glucopyranoside; Genistine; Genistein glucoside; Genistoside; Genistein, 7-β-D-glucopyranoside; Genistein-7-O-glucoside; Genistein 7-glucoside |
| Molecular Formula | C21H20O10 |
| Molecular Weight | 432.38 |
| Purity | ≥95 (HPLC) |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 788.9±60.0 °C at 760 mmHg |
| Melting Point | 254ºC |
| Appearance | colorless crystal |
| Storage Condition | Store refrigerated at -20°C |
| Application | Genistin is the primary isoflavone in soybeans and soy products. |
| PubChem ID | 24895028 |
| MDL Number | MFCD00016883 |
| SMILES | OC[C@H]1O[C@@H](Oc2cc(O)c3C(=O)C(=COc3c2)c4ccc(O)cc4)[C@H](O)[C@@H](O)[C@@H]1O |
| InChI | 1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-5-13(24)16-14(6-11)29-8-12(17(16)25)9-1-3-10(23)4-2-9/h1-6,8,15,18-24,26-28H,7H2/t15-,18-,19+,20-,21-/m1/s1 |
| InChI Key | ZCOLJUOHXJRHDI-CMWLGVBASA-N |
| Beilstein/REAXYS | 64479 |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/22548_1_529_59_9.pdf |
| Bioactivity | Genistin is the major isoflavonoid of soybeans and soy products. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Flavonoids In Vitro Genistin is the major isoflavonoid of soybeans and soy products. Genistin shows a dose-dependent superoxide scavenging effect and exhibits major effect at 200 μM, corresponding in activity to 0.08 U/mg protein superoxide dismutase (SOD). Results demonstrate that Genistin exhibits a significantly (P<0.01) and a dose-dependent inhibitory effect on the human cancer cell examined, and at higher concentration (100 μM), the cell viability is 59%. Genistin also induces a significant and dose-dependent increase in ROS formation when compare with the untreated control[1]. In Vivo Myocardial infarct is markedly diminished by pretreatment with Genistin, particularly at the high dose. After 1 h of reperfusion, preconditioning with Genistin at dosages of 20 to 60 mg/kg significantly attenuats the release of lactate dehydrogenase (LDH), creatine kinase (CK) in a dose-dependent manner compare with the I/R group. Results show that the level of malondialdehyde (MDA) is decreased and the activities of superoxide dismutase (SOD) and catalase (CAT) are increased as well as an increased glutathione (GSH) level in a dose-dependent manner by Genistin treatment in I/R. Pretreatment with Genistin (20, 40 and 60 mg/kg) also prevents the expression of P2X7, p-IκBα, and p-NF-κB p65 compare with the model group[2]. Cell Assay M14 human melanoma cells are used and grown in RPMI containing 10% fetal calf serum, 100 U/mL penicillin, 100 μg/mL streptomycin, and 25 μg/mL fungizone. After 24 h of incubation at 37°C under a humidified 5% carbon dioxide to allow cell attachment, the cells are treated with different concentrations (12, 25, 50, and 100 μM) of Genistin and daidzin, and incubated for 72 h under the same conditions[1]. Animal Admin Sprague-Dawley rats (male, 250 to 300 g) are used to establish the I/R injury animal model and used in this experiment. Rats are randomly apportioned in equal animals (n=10) to five experimental groups: (1) sham group: rats are subjected to the entire surgical procedure but without the induction of I/R; (2) model group: I/R injury animal model is constructed by left anterior descending coronary artery (LAD) ligation for 30 min, and then the LAD is allowed 1 h reperfusion; and (3) three Genistin-treated groups: different doses (20, 40, and 60 mg/kg body weight, resp.) of Genistin dissolved in 0.5% sodium carboxyl methyl cellulose (CMC-Na) solution are given intragastrically for 5 days before operation[2]. References [1]. Russo A, et al. Genistin inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells. J Nutr Biochem. 2006 Feb;17(2):103-8. [2]. Gu M, et al. Cardioprotective Effects of Genistin in Rat Myocardial Ischemia-Reperfusion Injury Studies by Regulation of P2X7/NF-κB Pathway. Evid Based Complement Alternat Med. 2016;2016:5381290. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 788.9±60.0 °C at 760 mmHg Melting Point 254ºC Molecular Formula C21H20O10 Molecular Weight 432.378 Flash Point 280.7±26.4 °C Exact Mass 432.105652 PSA 170.05000 LogP 0.79 Vapour Pressure 0.0±2.9 mmHg at 25°C Index of Refraction 1.717 InChIKey ZCOLJUOHXJRHDI-CMWLGVBASA-N SMILES O=c1c(-c2ccc(O)cc2)coc2cc(OC3OC(CO)C(O)C(O)C3O)cc(O)c12 |
| Use of | Genistin is the major isoflavonoid of soybeans and soy products. Properties Articles40 Name genistein 7-O-β-D-glucoside Synonym More Synonyms Genistin Biological Activity Description Genistin is the major isoflavonoid of soybeans and soy products. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Flavonoids In Vitro Genistin is the major isoflavonoid of soybeans and soy products. Genistin shows a dose-dependent superoxide scavenging effect and exhibits major effect at 200 μM, corresponding in activity to 0.08 U/mg protein superoxide dismutase (SOD). Results demonstrate that Genistin exhibits a significantly (P<0.01) and a dose-dependent inhibitory effect on the human cancer cell examined, and at higher concentration (100 μM), the cell viability is 59%. Genistin also induces a significant and dose-dependent increase in ROS formation when compare with the untreated control[1]. References [1]. Russo A, et al. Genistin inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells. J Nutr Biochem. 2006 Feb;17(2):103-8. Chemical & Physical Properties Molecular Formula C21H20O10 Exact Mass 432.105652 PSA 170.05000 Index of Refraction 1.717 InChIKey ZCOLJUOHXJRHDI-CMWLGVBASA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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