CAS Number521-61-9
Synonyms1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione; Emodin 3-methyl ether; EINECS 208-315-7; MFCD00017374; Emodin monomethyl ether; Parietin; Methoxyemodin; 1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione; Emodin-3-methyl ether; Rheochrysidin; physicion; phycion; 1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone; Physcion; 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone,Emodin-3-methyl ether; 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone; 1,8-dihydroxy-5-methyl-3-methoxy-9,10-anthraquinone; Physcione
Molecular FormulaC16H12O5
Molecular Weight284.26
Purity≥98.0 (TLC)%
Density1.4±0.1 g/cm3
Boiling Point560.5±50.0 °C at 760 mmHg
Melting Point196-206°C
AppearanceSolid;White to Yellow to Orange powder to crystal
EINECS208-315-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 521-61-9 |
| Catalog No. | 2A-9022482 |
| Chinese Name | 大黄素甲醚 |
| Synonyms | 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione; Emodin 3-methyl ether; EINECS 208-315-7; MFCD00017374; Emodin monomethyl ether; Parietin; Methoxyemodin; 1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione; Emodin-3-methyl ether; Rheochrysidin; physicion; phycion; 1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone; Physcion; 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone,Emodin-3-methyl ether; 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone; 1,8-dihydroxy-5-methyl-3-methoxy-9,10-anthraquinone; Physcione |
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.26 |
| Purity | ≥98.0 (TLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 560.5±50.0 °C at 760 mmHg |
| Melting Point | 196-206°C |
| Appearance | Solid;White to Yellow to Orange powder to crystal |
| Storage Condition | Store in a cool, dry, well-ventilated warehouse. K |
| Application | Physcion (Parietin) is an anthraquinone substance obtained from the traditional Chinese medicine rhubarb. It is a 6-phosphogluconate dehydrogenase inhibitor with IC50 and Kd values of 38.5 μM and 26 |
| EINECS | 208-315-7 |
| HTC | 2914699010 |
| PubChem ID | 57647675 |
| MDL Number | MFCD00017374 |
| SMILES | COc1cc(O)c2C(=O)c3c(O)cc(C)cc3C(=O)c2c1 |
| InChI | 1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3 |
| InChI Key | FFWOKTFYGVYKIR-UHFFFAOYSA-N |
| Beilstein/REAXYS | 6770499 |
| NACRES Code | NA.25 |
| UNSPSC | 85151701 |
| Hazard Symbols | Transport |
| MSDS | msds/22482_1_521_61_9.pdf |
| Bioactivity | Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2]. Related Catalog Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Target IC50: 38.5 μM (6-phosphogluconate dehydrogenase)[1] Kd: 26.0 μM (6-phosphogluconate dehydrogenase)[1] References [1]. Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96. [2]. Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 560.5±50.0 °C at 760 mmHg Melting Point 196-206°C Molecular Formula C16H12O5 Molecular Weight 284.26 Flash Point 215.4±23.6 °C Exact Mass 284.068481 PSA 83.83000 LogP 5.20 Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.678 InChIKey FFWOKTFYGVYKIR-UHFFFAOYSA-N SMILES COc1cc(O)c2c(c1)C(=O)c1cc(C)cc(O)c1C2=O Storage condition -20°C Freezer, Under Inert Atmosphere |
| Use of | Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2]. Properties Articles40 Name 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione Synonym More Synonyms Physcion Biological Activity Description Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2]. Related Catalog Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology IC50: 38.5 μM (6-phosphogluconate dehydrogenase)[1] Kd: 26.0 μM (6-phosphogluconate dehydrogenase)[1] References [1]. Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96. [2]. Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640. Chemical & Physical Properties Molecular Formula C16H12O5 Exact Mass 284.068481 PSA 83.83000 Index of Refraction 1.678 InChIKey FFWOKTFYGVYKIR-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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