CAS Number491-70-3
SynonymsEINECS 207-741-0; Flavopurpol; 5,7,3',4'-tetrahydroxyflavon; 3' 4' 5 7-tetrahydroxyflavone; LUTEOLOL; 3',4',5,7-tetrahydroxy-flavone; FLACITRAN; Cyanidenon 1470; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one; Digitoflavone; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-benzopyrone; 5,7,3',4'-tetrahydroxyflavone; Daphneflavonol; weldlake; cyanidenon; Luteolin; 3',4',5,7-Tetrahydroxyflavone; Salifazide; MFCD08460272
Molecular FormulaC15H10O6
Molecular Weight286.24
Purity≥98 (TLC)%
Density1.7±0.1 g/cm3
Boiling Point616.1±55.0 °C at 760 mmHg
Melting Point~330 °C (lit.)
Appearancepowder
EINECS207-741-0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 491-70-3 |
| Catalog No. | 2A-9022230 |
| Chinese Name | 木犀草素; 3',4',5,7-四羟基黄酮 |
| Synonyms | EINECS 207-741-0; Flavopurpol; 5,7,3',4'-tetrahydroxyflavon; 3' 4' 5 7-tetrahydroxyflavone; LUTEOLOL; 3',4',5,7-tetrahydroxy-flavone; FLACITRAN; Cyanidenon 1470; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one; Digitoflavone; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-benzopyrone; 5,7,3',4'-tetrahydroxyflavone; Daphneflavonol; weldlake; cyanidenon; Luteolin; 3',4',5,7-Tetrahydroxyflavone; Salifazide; MFCD08460272 |
| Molecular Formula | C15H10O6 |
| Molecular Weight | 286.24 |
| Purity | ≥98 (TLC) |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 616.1±55.0 °C at 760 mmHg |
| Melting Point | ~330 °C (lit.) |
| Appearance | powder |
| Storage Condition | Store sealed at 2-8°C in a ventilated, dry environ |
| Application | Luteolin is a natural flavonoid compound that has very important anti-cancer potential. |
| EINECS | 207-741-0 |
| HTC | 2932999099 |
| PubChem ID | 24896520 |
| MDL Number | MFCD00017309 |
| SMILES | Oc1cc(O)c2C(=O)C=C(Oc2c1)c3ccc(O)c(O)c3 |
| InChI | 1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H |
| InChI Key | IQPNAANSBPBGFQ-UHFFFAOYSA-N |
| Beilstein/REAXYS | 292084 |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/22230_1_491_70_3.pdf |
| Bioactivity | Luteolin is a falconoid compound, which exhibits anticancer properties.IC50 value:Target: A natural for anticancer.In vitro: Luteolin exerted an anticancer effect against NCI-H460 cells through Sirt1-mediated apoptosis and the inhibition of cell migration [1]. The treatment of luteolin upregulated the expression levels of transforming growth factor β1 (TGF-β1), p21WAF1/CIP1, p27KIP1, Smad4, and Fas in HCC cells. Luteolin induced apoptotic cell death in Hep3B cells while caused G1 arrest in HepG2 cells. And it induces apoptosis from G1 arrest via three signaling pathways of TGF-β1, p53, and Fas/Fas-ligand in HCC cells [2].In vivo: The study of the effect of Luteolin on the improvement of cancerous cachexia in model mice showed that luteolin can improve the symptoms of cancer cachexia model mice.The mechanism may be related to inhibition of proteasome and calcium activated protease activity and lower the levels of cytokines [3]. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Autophagy >> Mitophagy Natural Products >> Flavonoids Research Areas >> Cancer References [1]. Liping Ma, et al. Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of Sirt1-mediated apoptosis. Molecular MedicineReports, 2015, 12 (3): 4196-4202 [2]. Su Bog Yee, et al. Growth inhibition of luteolin on HepG2 cells is induced via p53 and Fas/Fas-ligand besides the TGF-β pathway. International Journal of Oncology, 2015, 47 (2): 747-754 [3]. Pang Tao, et al. Effect of Luteolin on the Improvement of Cancerous Cachexia in Model Mice. China Pharmacy, 2015-07 [4]. Divyashree Ravishankar, et al. Exploring quercetin and luteolin derivatives as antiangiogenic agents. European Journal of Medicinal ChemistryVolume 97, 5 June 2015, Pages 259-274 Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 616.1±55.0 °C at 760 mmHg Melting Point ~330 °C(lit.) Molecular Formula C15H10O6 Molecular Weight 286.236 Flash Point 239.5±25.0 °C Exact Mass 286.047729 PSA 111.13000 LogP 2.40 Vapour Pressure 0.0±1.8 mmHg at 25°C Index of Refraction 1.768 InChIKey IQPNAANSBPBGFQ-UHFFFAOYSA-N SMILES O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 Storage condition 2-8°C |
| Use of | Properties Articles211 Name luteolin Synonym More Synonyms Luteolin Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Autophagy >> Mitophagy Natural Products >> Flavonoids Research Areas >> Cancer References [1]. Liping Ma, et al. Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of Sirt1-mediated apoptosis. Molecular MedicineReports, 2015, 12 (3): 4196-4202 [3]. Pang Tao, et al. Effect of Luteolin on the Improvement of Cancerous Cachexia in Model Mice. China Pharmacy, 2015-07 [4]. Divyashree Ravishankar, et al. Exploring quercetin and luteolin derivatives as antiangiogenic agents. European Journal of Medicinal ChemistryVolume 97, 5 June 2015, Pages 259-274 Chemical & Physical Properties Molecular Formula C15H10O6 Exact Mass 286.047729 PSA 111.13000 Index of Refraction 1.768 InChIKey IQPNAANSBPBGFQ-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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