CAS Number537-42-8
Synonyms4-(3,5-Dimethoxystyryl)phenol; 4-[(E)-2-(3,5-Diméthoxyphényl)éthènyl]phénol; 3,5-Dimethoxy-4'-hydroxy-trans-stilbene; 3',5'-Dimethoxy-4-stilbenol; 4-(2-(3,5-Dimethoxyphenyl)ethenyl)phenol; 4-[(E)-2-(3,5-Dimethoxyphenyl)vinyl]phenol; (E)-4-(3,5-Dimethoxystyryl)phenol; trans-1-(3,5-Dimethoxyphenyl)-2-(4-hydroxyphenyl)ethylene; Pterostilbene; 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol; Pterostilbene,Pterocarpus marsupium; (E)-pterostilbene; 3,5-dimethoxy-4'-hydroxystilbene; 4'-hydroxy-3,5-dimethoxystilbene; 4'-Hydroxy-3,5-dimethoxy-trans-stilbene
Molecular FormulaC16H16O3
Molecular Weight256.30
Purity≥97 (HPLC)%
Density1.2±0.1 g/cm3
Boiling Point420.5±35.0 °C at 760 mmHg
Melting Point89-92ºC
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 537-42-8 |
| Catalog No. | 2A-9022689 |
| Chinese Name | 紫檀芪 |
| Synonyms | 4-(3,5-Dimethoxystyryl)phenol; 4-[(E)-2-(3,5-Diméthoxyphényl)éthènyl]phénol; 3,5-Dimethoxy-4'-hydroxy-trans-stilbene; 3',5'-Dimethoxy-4-stilbenol; 4-(2-(3,5-Dimethoxyphenyl)ethenyl)phenol; 4-[(E)-2-(3,5-Dimethoxyphenyl)vinyl]phenol; (E)-4-(3,5-Dimethoxystyryl)phenol; trans-1-(3,5-Dimethoxyphenyl)-2-(4-hydroxyphenyl)ethylene; Pterostilbene; 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol; Pterostilbene,Pterocarpus marsupium; (E)-pterostilbene; 3,5-dimethoxy-4'-hydroxystilbene; 4'-hydroxy-3,5-dimethoxystilbene; 4'-Hydroxy-3,5-dimethoxy-trans-stilbene |
| Molecular Formula | C16H16O3 |
| Molecular Weight | 256.30 |
| Purity | ≥97 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 420.5±35.0 °C at 760 mmHg |
| Melting Point | 89-92ºC |
| Appearance | solid |
| Water Solubility | DMSO: >20mg/mL |
| Storage Condition | 2-8°C |
| Packaging | Ⅲ |
| Application | Pterostilbene is a stilbene compound obtained from blueberries and rosewood [1], which has antioxidant, anti-inflammatory, anti-cancer, anti-diabetic and anti-obesity effects [1][4]. Pterostilbene inh |
| HTC | 2909500000 |
| UN(IATA) | 3077 |
| PubChem ID | 24724573 |
| MDL Number | MFCD00238710 |
| SMILES | COc1cc(OC)cc(\C=C\c2ccc(O)cc2)c1 |
| InChI | 1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+ |
| InChI Key | VLEUZFDZJKSGMX-ONEGZZNKSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 9.0 |
| MSDS | msds/22689_1_537_42_8.pdf |
| Bioactivity | Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium[1]. Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties[1][4]. Pterostilbene blocks ROS production[3], also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide[4]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Research Areas >> Inflammation/Immunology Natural Products >> Phenols In Vitro Pterostilbene (0, 5, 25, 50, 100, 200 and 400 µM) shows inhibitory activity against the growth of HeLa cells, with IC50s of 101.2 µM and 65.9 µM at 24 and 48 hrs, respectively. Ipterostilbene (0, 25, 100 and 200 µM) also induces the apoptosis HeLa cells[2]. Pterostilbene (0.05, 0.1, 0.15 and 0.2 mM) has high anti-oxidant activity against DPPH, ABTS, hydroxyl, superoxide, hydrogen peroxide in a dose-dependent manner. Pterostilbene decreases lipid peroxides and hydroperoxides, reduces protein carbonyl groups and restores protein sulphydryl groups in response to damage by TBHP and As-Fe2+. Pterostilbene also inhibits single strand breaks in pBR322[4]. In Vivo Pterostilbene (30 mg/kg daily, p.o. for 21 days) inhibits reactive oxygen species production in the animal model of inflammation[3]. References [1]. McCormack D, et al. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482. [2]. Hong Bin W, et al. Pterostilbene (3',5'-dimethoxy-resveratrol) exerts potent antitumor effects in HeLa human cervical cancer cells via disruption of mitochondrial membrane potential, apoptosis induction and targeting m-TOR/PI3K/Akt signalling pathway. J BUON. 2018 Sep-Oct;23(5):1384-1389. [3]. Perecko T, et al. The effects of pterostilbene on neutrophil activity in experimental model of arthritis. Biomed Res Int. 2013;2013:106041. [4]. Acharya JD, et al. Protective effect of Pterostilbene against free radical mediated oxidative damage. BMC Complement Altern Med. 2013 Sep 26;13:238. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 420.5±35.0 °C at 760 mmHg Melting Point 89-92ºC Molecular Formula C16H16O3 Molecular Weight 256.296 Flash Point 208.1±25.9 °C Exact Mass 256.109955 PSA 38.69000 LogP 4.13 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.640 InChIKey VLEUZFDZJKSGMX-ONEGZZNKSA-N SMILES COc1cc(C=Cc2ccc(O)cc2)cc(OC)c1 Storage condition 2-8°C Water Solubility DMSO: >20mg/mL |
| Use of | Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium[1]. Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties[1][4]. Pterostilbene blocks ROS production[3], also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide[4]. Properties Articles43 Name pterostilbene Synonym More Synonyms pterostilbene Biological Activity Description Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium[1]. Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties[1][4]. Pterostilbene blocks ROS production[3], also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide[4]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Research Areas >> Inflammation/Immunology Natural Products >> Phenols References [1]. McCormack D, et al. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482. [2]. Hong Bin W, et al. Pterostilbene (3',5'-dimethoxy-resveratrol) exerts potent antitumor effects in HeLa human cervical cancer cells via disruption of mitochondrial membrane potential, apoptosis induction and targeting m-TOR/PI3K/Akt signalling pathway. J BUON. 2018 Sep-Oct;23(5):1384-1389. [3]. Perecko T, et al. The effects of pterostilbene on neutrophil activity in experimental model of arthritis. Biomed Res Int. 2013;2013:106041. [4]. Acharya JD, et al. Protective effect of Pterostilbene against free radical mediated oxidative damage. BMC Complement Altern Med. 2013 Sep 26;13:238. Chemical & Physical Properties Molecular Formula C16H16O3 Exact Mass 256.109955 PSA 38.69000 Index of Refraction 1.640 InChIKey VLEUZFDZJKSGMX-ONEGZZNKSA-N |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 5.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3077 International Maritime Transport Danger Regulations: 3077 International Air Transport Danger Regulations: 3077 14.2 Names specified by the United Nations (UN) European land transport hazard regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Pterostilbene) IMDG Code: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Pterostilbene) International air transport hazard regulations: Environmentally hazardous substance, solid, n.o.s. (Pterostilbene) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations Maritime Pollutants: Yes International Air Transport Dangerous Regulations: Yes 14.6 Special reminder to users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3), |
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