CAS Number81-55-0
Synonyms4,5-Dinitrochrysazin; 1,8 DIHYDROXY 4,5 DINITRO AQ; 4,5-Dinitrodanthron; 1,8-dihydroxy-4,5-dinitroanthra-9,10-quinone; 1,8-dihydroxy-4,5-dinitro-anthraquinon; Dihydroxy-4,5-dinitroanthraquinone; MFCD00019149; 1,8-Dihydroxy-4,5-dinitroanthracene-9,10-dione; 1,8-Dihydroxy-4,5-dinitro-anthrachinon; 1,8-dihydroxy-4,5-dinitro-anthraquinone; 1,8-dihydroxy-4,5-dinitro-9,10-anthracenedione; EINECS 201-360-3; 1,8-Dihydroxy-4,5-dinitro-9,10-anthraquinone; 1,8-Dihydroxy-4,5-di; 4,5 DINITROCHRYSAZINE; 4,5-dinitro-1,8-dihydroxyanthraquinone
Molecular FormulaC14H6N2O8
Molecular Weight330.206
Purity98.00%
Density1.8±0.1 g/cm3
Boiling Point669.4±55.0 °C at 760 mmHg
Melting Point225 °C (dec.)(lit.)
AppearanceBrown golden solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 81-55-0 |
| Catalog No. | 2A-9017349 |
| Chinese Name | 1,8-二羟基-4,5-二硝基蒽醌 |
| Synonyms | 4,5-Dinitrochrysazin; 1,8 DIHYDROXY 4,5 DINITRO AQ; 4,5-Dinitrodanthron; 1,8-dihydroxy-4,5-dinitroanthra-9,10-quinone; 1,8-dihydroxy-4,5-dinitro-anthraquinon; Dihydroxy-4,5-dinitroanthraquinone; MFCD00019149; 1,8-Dihydroxy-4,5-dinitroanthracene-9,10-dione; 1,8-Dihydroxy-4,5-dinitro-anthrachinon; 1,8-dihydroxy-4,5-dinitro-anthraquinone; 1,8-dihydroxy-4,5-dinitro-9,10-anthracenedione; EINECS 201-360-3; 1,8-Dihydroxy-4,5-dinitro-9,10-anthraquinone; 1,8-Dihydroxy-4,5-di; 4,5 DINITROCHRYSAZINE; 4,5-dinitro-1,8-dihydroxyanthraquinone |
| Molecular Formula | C14H6N2O8 |
| Molecular Weight | 330.206 |
| Purity | 98.00 |
| Density | 1.8±0.1 g/cm3 |
| Boiling Point | 669.4±55.0 °C at 760 mmHg |
| Melting Point | 225 °C (dec.)(lit.) |
| Appearance | Brown golden solid |
| Storage Condition | This product should be sealed and stored in a dry |
| Application | 1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP006; DHDNE) is an effective inhibitor of the dengue virus protein serine protease NS2B/3. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular protease |
| HTC | 2914700090 |
| SMILES | O=C1c2c(O)ccc([N+](=O)[O-])c2C(=O)c2c([N+](=O)[O-])ccc(O)c21 |
| InChI | InChI=1S/C14H6N2O8/c17-7-3-1-5(15(21)22)9-11(7)14(20)12-8(18)4-2-6(16(23)24)10(12)13(9)19/h1-4,17-18H |
| InChI Key | GJCHQJDEYFYWER-UHFFFAOYSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/17349_2_81_55_0.pdf |
| Bioactivity | 1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile. 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM[1]. Related Catalog Research Areas >> Infection In Vitro 1,8-Dihydroxy-4,5-dinitroanthraquinone (50 μM-2 mM; 90 minutes) inhibits NS2B/3 lyses, and acts significantly and significantly on BHK-21 cells at 100 μM [1]. References [1]. Constant DA, et al. Targeting intramolecular proteinase NS2B/3 cleavages for trans-dominant inhibition of dengue virus. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10136-10141. Chemical & Physical Properties Density 1.8±0.1 g/cm3 Boiling Point 669.4±55.0 °C at 760 mmHg Melting Point 225 °C (dec.)(lit.) Molecular Formula C14H6N2O8 Molecular Weight 330.206 Flash Point 280.8±20.0 °C Exact Mass 330.012421 PSA 166.24000 LogP 4.94 Vapor Pressure 0.0±2.1 mmHg at 25°C Index of Refraction 1.782 InChIKey GJCHQJDEYFYWER-UHFFFAOYSA-N SMILES O=C1c2c(O)ccc([N+](=O)[O-])c2C(=O)c2c([N+](=O)[O-])ccc(O)c21 Stability Stable. Incompatible with strong oxidizing agents. |
| Use of | Properties Name 1,8-Dihydroxy-4,5-dinitroanthraquinone Synonym More Synonyms 1,8-Dihydroxy-4,5-dinitroanthraquinone Biological Activity Related Catalog Research Areas >> Infection References Chemical & Physical Properties Molecular Formula C14H6N2O8 Exact Mass 330.012421 PSA 166.24000 Index of Refraction 1.782 InChIKey GJCHQJDEYFYWER-UHFFFAOYSA-N Stability Stable. Incompatible with strong oxidizing agents. |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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