CAS Number53-16-7
SynonymsFollestrine; Ovifollin; Folliculine; EINECS 200-164-5; Estrone-A; Destrone; Thelestrin; Hormofollin; Oestrin; Femestrone; Cristallovar; E 1; Hormovarine; 3-Hydroxyestra-1,3,5(10)-trien-17one; Theelin; Femidyn; Oestrone; Kestrone; Kolpon; Endofolliculina; Wynestron; Estrin; Folipex; Hiestrone; Tokokin; Disynformon; Ketohydroxyestrin; 3-Hydroxy-1,3,5(10)-estratrien-17-one; 3-Hydroxyoestra-1,3,5(10)-trien-17-one; Glandubolin
Molecular FormulaC18H22O2
Molecular Weight270.37
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point445.2±45.0 °C at 760 mmHg
Melting Point258-260 °C (lit.)
AppearanceWhite crystalline powder
EINECS200-164-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 53-16-7 |
| Catalog No. | 2A-9016642 |
| Chinese Name | 雌酚酮 |
| Synonyms | Follestrine; Ovifollin; Folliculine; EINECS 200-164-5; Estrone-A; Destrone; Thelestrin; Hormofollin; Oestrin; Femestrone; Cristallovar; E 1; Hormovarine; 3-Hydroxyestra-1,3,5(10)-trien-17one; Theelin; Femidyn; Oestrone; Kestrone; Kolpon; Endofolliculina; Wynestron; Estrin; Folipex; Hiestrone; Tokokin; Disynformon; Ketohydroxyestrin; 3-Hydroxy-1,3,5(10)-estratrien-17-one; 3-Hydroxyoestra-1,3,5(10)-trien-17-one; Glandubolin |
| Molecular Formula | C18H22O2 |
| Molecular Weight | 270.37 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 445.2±45.0 °C at 760 mmHg |
| Melting Point | 258-260 °C (lit.) |
| Appearance | White crystalline powder |
| Water Solubility | 0.03 g/L |
| Storage Condition | Store in an airtight container away from light |
| Packaging | I; II; III |
| Application | Estrone is estrogen. |
| EINECS | 200-164-5 |
| HTC | 2937290090 |
| PubChem ID | 329823447 |
| MDL Number | MFCD00003620 |
| SMILES | C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O |
| InChI | 1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1 |
| InChI Key | DNXHEGUUPJUMQT-CBZIJGRNSA-N |
| Beilstein/REAXYS | 1915077 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1 |
| Risk Codes | R45;R60;R61 |
| Safety Description | S53;S45 |
| MSDS | msds/16642_1_53_16_7.pdf |
| Bioactivity | Estrone is an estrogenic hormone.Target: Estrogen Receptor/ERREstrone (E1) is an estrogenic hormone secreted by the ovary as well as adipose tissue with the chemical name of 3-hydroxyestra-1,3,5(10)-triene-17-one and the chemical formula C18H22O2. Estrone is one of several natural estrogens, which also include estriol and estradiol. Estrone is the least abundant of the three hormones; estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy. Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol. It is the predominant estrogen in postmenopausal women [1, 2]. Related Catalog Signaling Pathways >> Others >> Estrogen Receptor/ERR Natural Products >> Steroids Research Areas >> Endocrinology Target Human Endogenous Metabolite References [1]. Hoffmann, B., et al., [Profiles of estrone, estrone sulfate and progesterone in donkey (Equus asinus) mares during pregnancy]. Tierarztl Prax Ausg G Grosstiere Nutztiere, 2014. 42(1): p. 32-9. [2]. Oneson, I.B. and S.L. Cohen, The nature of the conjugated estrone in human pregnancy urine. Endocrinology, 1952. 51(3): p. 173-82. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 445.2±45.0 °C at 760 mmHg Melting Point 258-260 °C(lit.) Molecular Formula C18H22O2 Molecular Weight 270.366 Flash Point 189.7±21.3 °C Exact Mass 270.161987 PSA 37.30000 LogP 3.69 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.587 InChIKey DNXHEGUUPJUMQT-CBZIJGRNSA-N SMILES CC12CCC3c4ccc(O)cc4CCC3C1CCC2=O Storage condition 2~8°C Water Solubility 0.03 g/L |
| Use of | Estrone is an estrogenic hormone.Target: Estrogen Receptor/ERREstrone (E1) is an estrogenic hormone secreted by the ovary as well as adipose tissue with the chemical name of 3-hydroxyestra-1,3,5(10)-triene-17-one and the chemical formula C18H22O2. Estrone is one of several natural estrogens, which also include estriol and estradiol. Estrone is the least abundant of the three hormones; estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy. Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol. It is the predominant estrogen in postmenopausal women [1, 2]. Properties Articles153 Name estrone Synonym More Synonyms Estrone Biological Activity Description Estrone is an estrogenic hormone.Target: Estrogen Receptor/ERREstrone (E1) is an estrogenic hormone secreted by the ovary as well as adipose tissue with the chemical name of 3-hydroxyestra-1,3,5(10)-triene-17-one and the chemical formula C18H22O2. Estrone is one of several natural estrogens, which also include estriol and estradiol. Estrone is the least abundant of the three hormones; estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy. Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol. It is the predominant estrogen in postmenopausal women [1, 2]. Related Catalog Signaling Pathways >> Others >> Estrogen Receptor/ERR Natural Products >> Steroids Research Areas >> Endocrinology Human Endogenous Metabolite References [1]. Hoffmann, B., et al., [Profiles of estrone, estrone sulfate and progesterone in donkey (Equus asinus) mares during pregnancy]. Tierarztl Prax Ausg G Grosstiere Nutztiere, 2014. 42(1): p. 32-9. [2]. Oneson, I.B. and S.L. Cohen, The nature of the conjugated estrone in human pregnancy urine. Endocrinology, 1952. 51(3): p. 173-82. Chemical & Physical Properties Molecular Formula C18H22O2 Exact Mass 270.161987 PSA 37.30000 Index of Refraction 1.587 InChIKey DNXHEGUUPJUMQT-CBZIJGRNSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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