CAS Number55-06-1
SynonymsLiothyronine (sodium); Cytobin; Liothyronine sodium salt; Ibiot; Basoprocin; Sodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate; UNII:GCA9VV7D2N; Sodium 3,3',5-triiodo-L-thyronine; Sodium T3; T3,NA; EINECS 200-223-5; sodium (S)-2-amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoate; Liothyronine sodium; Cynomel; sodium triiodothyronine; Cytomine; Triothyrone; Cyomel; L-3-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]alanine Monosodium Salt; T3 sodium salt; Triostat; 3,3',5-Triiodo-L-thyronine sodium salt; Tertroxin; tri-iodothyronine sodium; L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, sodium salt (1:1); Sodium L-Triiodothyronine; MFCD00002594; T3; 3,3',5-Triiodo-L-thyronine (sodium)
Molecular FormulaC15H11I3NNaO4
Molecular Weight672.96
Purity≥95%
Boiling Point563.5ºC at 760 mmHg
Melting Point205 °C (dec.)(lit.)
Appearancepowder
EINECS200-223-5
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 55-06-1 |
| Catalog No. | 2A-9016673 |
| Chinese Name | 3,3',5-三碘-L-甲腺原氨酸钠盐 |
| Synonyms | Liothyronine (sodium); Cytobin; Liothyronine sodium salt; Ibiot; Basoprocin; Sodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate; UNII:GCA9VV7D2N; Sodium 3,3',5-triiodo-L-thyronine; Sodium T3; T3,NA; EINECS 200-223-5; sodium (S)-2-amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoate; Liothyronine sodium; Cynomel; sodium triiodothyronine; Cytomine; Triothyrone; Cyomel; L-3-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]alanine Monosodium Salt; T3 sodium salt; Triostat; 3,3',5-Triiodo-L-thyronine sodium salt; Tertroxin; tri-iodothyronine sodium; L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, sodium salt (1:1); Sodium L-Triiodothyronine; MFCD00002594; T3; 3,3',5-Triiodo-L-thyronine (sodium) |
| Molecular Formula | C15H11I3NNaO4 |
| Molecular Weight | 672.96 |
| Purity | ≥95 |
| Boiling Point | 563.5ºC at 760 mmHg |
| Melting Point | 205 °C (dec.)(lit.) |
| Appearance | powder |
| Storage Condition | This product should be sealed and stored in a dry |
| Application | 3,3',5-Triiodo-L-thyronine sodium is a potent thyroid hormone that binds to and activates the beta1 thyroid hormone receptor (TRβ1). |
| EINECS | 200-223-5 |
| HTC | 2922509090 |
| PubChem ID | 24900372 |
| MDL Number | MFCD00002594 |
| SMILES | [Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O |
| InChI | 1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1 |
| InChI Key | SBXXSUDPJJJJLC-YDALLXLXSA-M |
| Beilstein/REAXYS | 8179867 |
| NACRES Code | NA.77 |
| UNSPSC | 12352209 |
| Safety Description | S24/25 |
| MSDS | msds/16673_1_55_06_1.pdf |
| Bioactivity | 3,3',5-Triiodo-L-thyronine sodium is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity. Related Catalog Signaling Pathways >> Others >> Thyroid Hormone Receptor Research Areas >> Cancer Research Areas >> Endocrinology Target TRβ1[1][2] In Vitro 3,3',5-Triiodo-L-thyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. 3,3',5-Triiodo-L-thyronine binds to human β1 thyroid hormone receptor (hTRβ1), and change its conformation. 3,3',5-Triiodo-L-thyronine promotes growth, induces differentiation and regualtes metabolic effects[2]. Cell Assay Thyroid hormone depleted (Td) serum is prepared. The growth of hepatocarcinoma cells in methylcellulose is performed. To determine the effect of 3,3',5-Triiodo-L-thyronine (T3) on the growth of cells, cells are plated at a density of 3 × 104 cells/60 mm dish on day 0, and incubated in medium containing 5% regular serum, 5% Td or 5% Td and 100 nM T3. The colony formation in methylcellulose is scored 3 weeks after initial plating[1]. References [1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. [2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. Chemical & Physical Properties Boiling Point 563.5ºC at 760 mmHg Melting Point 205 °C (dec.)(lit.) Molecular Formula C15H11I3NNaO4 Molecular Weight 672.955 Flash Point 294.6ºC Exact Mass 672.771973 PSA 95.61000 LogP 3.31830 InChIKey SBXXSUDPJJJJLC-YDALLXLXSA-M SMILES NC(Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)[O-].[Na+] |
| Use of | 3,3',5-Triiodo-L-thyronine sodium is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity. Properties Articles12 Name liothyronine sodium Synonym More Synonyms 3,3'',5-Triiodo-L-thyronine Sodium Salt Biological Activity Description 3,3',5-Triiodo-L-thyronine sodium is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity. Related Catalog Signaling Pathways >> Others >> Thyroid Hormone Receptor Research Areas >> Cancer Research Areas >> Endocrinology TRβ1[1][2] In Vitro 3,3',5-Triiodo-L-thyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. 3,3',5-Triiodo-L-thyronine binds to human β1 thyroid hormone receptor (hTRβ1), and change its conformation. 3,3',5-Triiodo-L-thyronine promotes growth, induces differentiation and regualtes metabolic effects[2]. References [1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. [2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. Chemical & Physical Properties Molecular Formula C15H11I3NNaO4 Exact Mass 672.771973 PSA 95.61000 LogP 3.31830 InChIKey SBXXSUDPJJJJLC-YDALLXLXSA-M |
| Tax Rebate | 13.0% |
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| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Supervision conditions A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
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