CAS Number55-03-8
SynonymsSodium l-thyroxin; L-3,3',5,5'-Tetraiodothyronine Sodium Salt; L-Thyroxine monosodium salt; Levaxin; Euthyrox; L-Tyrosine, O- (4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt; Sodium Levothyroxine; Eltroxin; Thyro-Tabs; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine Monosodium Salt; Levothroid; L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1); EINECS 200-221-4; SODIUM L-THYROXINE; Synthroid; L-Thyroxine sodium salt; Sodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate; Levothyroxine sodium; Oroxine; Levoxyl
Molecular FormulaC15H20I4NNaO9
Molecular Weight798.85 (anhydrous basis)
Purity98.00%
Boiling Point576.3ºC at 760 mmHg
Melting Point207-210 (dec.)(lit.)ºC
EINECS200-221-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 55-03-8 |
| Catalog No. | 2A-9016672 |
| Chinese Name | L-甲状腺素钠盐五水合物 |
| Synonyms | Sodium l-thyroxin; L-3,3',5,5'-Tetraiodothyronine Sodium Salt; L-Thyroxine monosodium salt; Levaxin; Euthyrox; L-Tyrosine, O- (4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt; Sodium Levothyroxine; Eltroxin; Thyro-Tabs; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine Monosodium Salt; Levothroid; L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1); EINECS 200-221-4; SODIUM L-THYROXINE; Synthroid; L-Thyroxine sodium salt; Sodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate; Levothyroxine sodium; Oroxine; Levoxyl |
| Molecular Formula | C15H20I4NNaO9 |
| Molecular Weight | 798.85 (anhydrous basis) |
| Purity | 98.00 |
| Boiling Point | 576.3ºC at 760 mmHg |
| Melting Point | 207-210 (dec.)(lit.)ºC |
| Packaging | II |
| Application | L-Thyroxine sodium (Levothyroxine sodium) is a synthetic thyroid hormone used in the treatment of hypothyroidism. The DIO enzyme converts L-Thyroxine (T4) into the biologically active triiodothyronine |
| EINECS | 200-221-4 |
| PubChem ID | 329750053 |
| MDL Number | MFCD06408007 |
| SMILES | O.[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O |
| InChI | 1S/C15H11I4NO4.Na.H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;1H2/q;+1;/p-1/t12-;;/m0../s1 |
| InChI Key | ANMYAHDLKVNJJO-LTCKWSDVSA-M |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/16672_1_55_03_8.pdf |
| Bioactivity | L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1]. Related Catalog Research Areas >> Endocrinology Signaling Pathways >> Others >> Thyroid Hormone Receptor In Vivo Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion[1]. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with standard diet (p<0.001). In the group treated with low doses of L-Thyroxine, an increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19). Rats treated with high doses of L-Thyroxine display a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03)[2]. References [1]. Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323. [2]. Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149. Chemical & Physical Properties Boiling Point 576.3ºC at 760 mmHg Melting Point 207-210 (dec.)(lit.)ºC Molecular Formula C15H20I4NNaO9 Molecular Weight 798.852 Flash Point 302.3ºC Exact Mass 798.668579 PSA 141.76000 LogP 3.60140 InChIKey YDTFRJLNMPSCFM-YDALLXLXSA-M SMILES NC(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)[O-].[Na+] |
| Use of | L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1]. Properties Name levothyroxine sodium anhydrous Synonym More Synonyms L-Thyroxine sodium Biological Activity Description L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1]. Related Catalog Research Areas >> Endocrinology Signaling Pathways >> Others >> Thyroid Hormone Receptor References [1]. Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323. [2]. Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149. Chemical & Physical Properties Molecular Formula C15H20I4NNaO9 Exact Mass 798.668579 PSA 141.76000 LogP 3.60140 InChIKey YDTFRJLNMPSCFM-YDALLXLXSA-M |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 2811 Proper Shipping Name: Toxic Solid, Organic, Not Otherwise Specified Packing grade: III |
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