CAS Number52-86-8
SynonymsEinalon S; 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone; Sernas; Peluces; r1625; Haldol; Halosten; MFCD00051423; 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone; 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone; haloperidol; Haloperidol [USAN:BAN:INN:JAN]; 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-bu; Serenace; 4-[4-(4-Chlorphenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorphenyl)butan-1-on; Keselan; Eukystol; 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone; EINECS 200-155-6; ALDO; Linton; haldol Decanoate; Aloperidin; Sigaperidol; Pernox; Sernel; Halol; 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one; Bioperidolo; Dozic
Molecular FormulaC21H23ClFNO2
Molecular Weight375.86
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point529.0±50.0 °C at 760 mmHg
Melting Point152 °C
Appearancepowder
EINECS200-155-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 52-86-8 |
| Catalog No. | 2A-9016637 |
| Chinese Name | 氟哌啶醇 |
| Synonyms | Einalon S; 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone; Sernas; Peluces; r1625; Haldol; Halosten; MFCD00051423; 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone; 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone; haloperidol; Haloperidol [USAN:BAN:INN:JAN]; 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-bu; Serenace; 4-[4-(4-Chlorphenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorphenyl)butan-1-on; Keselan; Eukystol; 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone; EINECS 200-155-6; ALDO; Linton; haldol Decanoate; Aloperidin; Sigaperidol; Pernox; Sernel; Halol; 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one; Bioperidolo; Dozic |
| Molecular Formula | C21H23ClFNO2 |
| Molecular Weight | 375.86 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 529.0±50.0 °C at 760 mmHg |
| Melting Point | 152 °C |
| Appearance | powder |
| Water Solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 |
| Storage Condition | Should be sealed and stored away from light. |
| Packaging | III |
| Application | Haloperidol is a potent dopamine D2 receptor antagonist and a neuroleptic drug. |
| EINECS | 200-155-6 |
| HTC | 2933399090 |
| UN(IATA) | UN 2811 |
| PubChem ID | 24277917 |
| MDL Number | MFCD00051423 |
| SMILES | OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3 |
| InChI | 1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 |
| InChI Key | LNEPOXFFQSENCJ-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(b) |
| Risk Codes | R60;R61;R25;R36/37/38;R43 |
| Safety Description | S53;S26;S36/37/39;S45 |
| MSDS | msds/16637_1_52_86_8.pdf |
| Bioactivity | Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease In Vivo Haloperidol (1 mg) intra-arterially attenuates the dopamine-induced pancreatic secretion. Haloperidol (3 mg) completely inhibits the action of 10 μg of dopamine in the pancreas of the dogs[1]. Haloperidol (10 mg/kg) as well as chlorpromazine (CPZ, 15 mg/kg) blocks mescaline-induced altered behavior within 7 to 10 minutes when injected into the mice 45 minutes after 50 mg/kg (2 µc) of mescaline. Haloperidol has no effect on mescaline disappearance[2]. Animal Admin Male albino mice of Swiss-Webster strain (33-36 g) are used, and all substances are given by i.p. injection in a volume of 0.5 mL. CPZ, haloperidoi and mescaline are all in time form of timeir imydrochlorides and the dose solutions are prepared at concentrations of 1.0, 0.66 and 3.3 mg/mL of 0.9% saline, respectively. The doses are: CPZ, 15 mg/kg; haloperidol, 10 mg/kg; mescaline, 50 mg/kg. Mice are pretreated with either CPZ or haloperidol 30 minutes before administration of mescaline. In some instances CPZ is injected 45 minutes after mescaline. Time animals are hmoused individually in a plexiglas cage and the gross behavior and locomotor activity. At selected intervals after mescaline, groups of mice are sacrificed by decapitation. Plasma is separated and stored at -20°C. The brain, liver, kidney, lung, spleen and heart are frozen on dry ice and stored at -20°C for 18 to 20 hours before they are used for assays. References [1]. Furuta Y, et al. Effects of enzyme inhibitors of catecholamine metabolism and of haloperidol on the pancreatic secretion induced by L-DOPA and by dopamine in dogs. Br J Pharmacol. 1973 Jan;47(1):77-84. [2]. Shah NS, et al. Effects of chlorpromazine and haloperidol on the disposition of mescaline-14C in mice. J Pharmacol Exp Ther. 1973 Aug;186(2):297-304. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 529.0±50.0 °C at 760 mmHg Melting Point 152 °C Molecular Formula C21H23ClFNO2 Molecular Weight 375.864 Flash Point 273.8±30.1 °C Exact Mass 375.140137 PSA 40.54000 LogP 3.01 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.581 InChIKey LNEPOXFFQSENCJ-UHFFFAOYSA-N SMILES O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 Storage condition Store at RT Water Solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL |
| Use of | Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic. Properties Articles179 Name haloperidol Synonym More Synonyms haloperidol Biological Activity Description Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease References [1]. Furuta Y, et al. Effects of enzyme inhibitors of catecholamine metabolism and of haloperidol on the pancreatic secretion induced by L-DOPA and by dopamine in dogs. Br J Pharmacol. 1973 Jan;47(1):77-84. Chemical & Physical Properties Exact Mass 375.140137 PSA 40.54000 Index of Refraction 1.581 InChIKey LNEPOXFFQSENCJ-UHFFFAOYSA-N Storage condition Store at RT |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Haloperidol) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Haloperidol) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Haloperidol) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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