CAS Number53-03-2
SynonymsMFCD00003608; In-Sone; MOPP; deltae; EINECS 200-160-3; 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione; Deltra; δ1-Cortisone; Delcortin; Cotone; D1-Dehydrocortisone; deltacortisone; Cortan; 1,4-Pregnadiene-17a,21-diol-3,11,20-trione; Wojtab; Precortal; Deltisone; u6020; deltacortene; Prednisone; D1-Cortisone; δ1-Dehydrocortisone
Molecular FormulaC21H26O5
Molecular Weight358.43
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point573.7±50.0 °C at 760 mmHg
Melting Point236-238 °C (lit.)
AppearanceWhite crystalline powder
EINECS200-160-3
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 53-03-2 |
| Catalog No. | 2A-9016641 |
| Chinese Name | 泼尼松 |
| Synonyms | MFCD00003608; In-Sone; MOPP; deltae; EINECS 200-160-3; 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione; Deltra; δ1-Cortisone; Delcortin; Cotone; D1-Dehydrocortisone; deltacortisone; Cortan; 1,4-Pregnadiene-17a,21-diol-3,11,20-trione; Wojtab; Precortal; Deltisone; u6020; deltacortene; Prednisone; D1-Cortisone; δ1-Dehydrocortisone |
| Molecular Formula | C21H26O5 |
| Molecular Weight | 358.43 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 573.7±50.0 °C at 760 mmHg |
| Melting Point | 236-238 °C (lit.) |
| Appearance | White crystalline powder |
| Storage Condition | Mainly used for various acute severe bacterial inf |
| Application | Prednisone (Adasone) is a corticosteroid agent that has immunosuppressive effects. |
| EINECS | 200-160-3 |
| HTC | 2937210000 |
| PubChem ID | 329750938 |
| MDL Number | MFCD00003608 |
| SMILES | O=C1C=C[C@@]2(C)C(CC[C@]([C@@](CC[C@@]3(C(CO)=O)O)([H])[C@]3(C)C4)([H])[C@]2([H])C4=O)=C1 |
| InChI | 1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 |
| InChI Key | XOFYZVNMUHMLCC-ZPOLXVRWSA-N |
| Beilstein/REAXYS | 2065301 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Xn |
| Risk Codes | R63 |
| Safety Description | S36/37/39;S45 |
| MSDS | msds/16641_1_53_03_2.pdf |
| Bioactivity | Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.Target: OthersPrednisone is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant drug. It is used to treat certain inflammatory diseases (such as moderate allergic reactions) and (at higher doses) some types of cancer, but has significant adverse effects. Because it suppresses the immune system, it leaves patients more susceptible to infections.Prednisone can also be used in the treatment of decompensated heart failure to potentiate renal responsiveness to diuretics, especially in heart failure patients with refractory diuretic resistance with large dose of loop diuretics. The mechanism is prednisone, as a glucocorticoid, can improve renal responsiveness to atrial natriuretic peptide by increasing the density of natriuretic peptide receptor type A in the renal inner medullary collecting duct, inducing a potent diuresis. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology Natural Products >> Steroids References [1]. RIEMER AD. Application of the newer corticosteroids to augment diuresis in congestive heart failure. Am J Cardiol. 1958 Apr;1(4):488-96. [2]. Zhang H, et al. Prednisone adding to usual care treatment for refractory decompensated congestive heart failure. Int Heart J. 2008 Sep;49(5):587-95. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 573.7±50.0 °C at 760 mmHg Melting Point 236-238 °C(lit.) Molecular Formula C21H26O5 Molecular Weight 358.428 Flash Point 314.8±26.6 °C Exact Mass 358.178009 PSA 91.67000 LogP 1.57 Vapour Pressure 0.0±3.6 mmHg at 25°C Index of Refraction 1.604 Storage condition 2~8°C |
| Use of | Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.Target: OthersPrednisone is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant drug. It is used to treat certain inflammatory diseases (such as moderate allergic reactions) and (at higher doses) some types of cancer, but has significant adverse effects. Because it suppresses the immune system, it leaves patients more susceptible to infections.Prednisone can also be used in the treatment of decompensated heart failure to potentiate renal responsiveness to diuretics, especially in heart failure patients with refractory diuretic resistance with large dose of loop diuretics. The mechanism is prednisone, as a glucocorticoid, can improve renal responsiveness to atrial natriuretic peptide by increasing the density of natriuretic peptide receptor type A in the renal inner medullary collecting duct, inducing a potent diuresis. Properties Articles230 Name prednisone Synonym More Synonyms Prednisone Biological Activity Description Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.Target: OthersPrednisone is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant drug. It is used to treat certain inflammatory diseases (such as moderate allergic reactions) and (at higher doses) some types of cancer, but has significant adverse effects. Because it suppresses the immune system, it leaves patients more susceptible to infections.Prednisone can also be used in the treatment of decompensated heart failure to potentiate renal responsiveness to diuretics, especially in heart failure patients with refractory diuretic resistance with large dose of loop diuretics. The mechanism is prednisone, as a glucocorticoid, can improve renal responsiveness to atrial natriuretic peptide by increasing the density of natriuretic peptide receptor type A in the renal inner medullary collecting duct, inducing a potent diuresis. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology Natural Products >> Steroids References [1]. RIEMER AD. Application of the newer corticosteroids to augment diuresis in congestive heart failure. Am J Cardiol. 1958 Apr;1(4):488-96. [2]. Zhang H, et al. Prednisone adding to usual care treatment for refractory decompensated congestive heart failure. Int Heart J. 2008 Sep;49(5):587-95. Chemical & Physical Properties Molecular Formula C21H26O5 Exact Mass 358.178009 PSA 91.67000 Index of Refraction 1.604 |
| Transport Info | Product Name: Prednisone |
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