CAS Number68401-81-0
SynonymsCeftizoxima; SK&F 88373-Z; Ceftizoxime; Ceftizoxima [INN-Spanish]; Ceftix; Ceftizoximum; Ceftizoximum [INN-Latin]; 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid; ceftizoximum [INN_la]; Cefizox; MFCD00072000; Eposerin; Epocelin
Molecular FormulaC13H13N5O5S2
Molecular Weight383.403
Purity98%
Density1.9±0.1 g/cm3
Melting Point227 °C(dec.)
AppearanceWhite or light yellow crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 68401-81-0 |
| Catalog No. | 2A-9009679 |
| Chinese Name | 头孢唑肟 |
| Synonyms | Ceftizoxima; SK&F 88373-Z; Ceftizoxime; Ceftizoxima [INN-Spanish]; Ceftix; Ceftizoximum; Ceftizoximum [INN-Latin]; 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid; ceftizoximum [INN_la]; Cefizox; MFCD00072000; Eposerin; Epocelin |
| Molecular Formula | C13H13N5O5S2 |
| Molecular Weight | 383.403 |
| Purity | 98 |
| Density | 1.9±0.1 g/cm3 |
| Melting Point | 227 °C(dec.) |
| Appearance | White or light yellow crystalline powder |
| Storage Condition | Room Temperature |
| Application | Ceftizoxime is a bacterial inhibitor that works by interfering with bacterial cell wall synthesis and inhibiting peptidoglycan cross-linking. |
| HTC | 2941905990 |
| SMILES | CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=CCSC12)c1csc(N)n1 |
| InChI | InChI=1S/C13H13N5O5S2.Na/c1-23-17-7(6-4-15-13(14)25-6)9(19)16-8-10(20)18-5(12(21)22)2-3-24-11(8)18;/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22);/q;+1/p-1/b17-7+;/t8-,11-;/m1./s1 |
| InChI Key | NNULBSISHYWZJU-LDYMZIIASA-N |
| Bioactivity | Ceftizoxime is a bacterial inhibitor which acts by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Target bacterial[1] In Vitro Ceftizoxime is a new parenteral cephalosporin derivative which is more active against various gram-negative bacilli, including the opportunistic pathogens such as Enterobacter, Citrobacter species, and Serratia marcescens, than cephalosporins and cephamycins such as cefotiam, cefamandole, cefuroxime, cefotaxime, and cefmetazole. Ceftizoxime shows a broad spectrum of antibacterial activity against aerobic gram-positive and gram-negative bacteria[1]. In Vivo The therapeutic effect of Ceftizoxime in mice infected with a small inoculum size is almost the same as that of cefotaxime[1]. Ceftizoxime is stable in biological fluids such as serum, urine, and tissue homogenates, but cefotaxime is unstable in rat tissue homogenates. Binding of ceftizoxime to serum protein in all species is the lowest of all the antibiotics: 31% for humans, 17% for dogs, and 32% for rats[2]. Animal Admin Rats[2] The animals used in this study include 6-week-old male JCL:ICR strain mice, 6-week-old male JCL:SD strain rats, 7.5- to 15.0-kg male beagle dogs, and 5.8- to 9.1-kg male rhesus monkeys. Ceftizoxime for injection is dissolved in 0.9% saline. Ceftizoxime is given in a dose of 20 mg/kg to all test animals. The volumes are: 0.25 mL per animal by the intravenous (i.v.) and subcutaneous routes to mice; 5 mL/kg of body weight by the intramuscular (i.m.) and i.v. routes to rats; and 0.5 mL/kg of body weight by the i.m. and i.v. routes to dogs and monkeys[1]. References [1]. Kamimura T, et al. Ceftizoxime (Ceftizoxime), a new parenteral cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother. 1979 Nov;16(5):540-8. [2]. Murakawa T, et al. Pharmacokinetics of ceftizoxime in animals after parenteral dosing. Antimicrob Agents Chemother. 1980 Feb;17(2):157-64. Chemical & Physical Properties Density 1.9±0.1 g/cm3 Melting Point 227 °C(dec.) Molecular Formula C13H13N5O5S2 Molecular Weight 383.403 Exact Mass 383.035797 PSA 200.75000 LogP 0.59 Index of Refraction 1.849 InChIKey NNULBSISHYWZJU-LDYMZIIASA-N SMILES CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=CCSC12)c1csc(N)n1 |
| Use of | Ceftizoxime is a bacterial inhibitor which acts by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan. Properties Name ceftizoxime Synonym More Synonyms Ceftizoxime Biological Activity Description Ceftizoxime is a bacterial inhibitor which acts by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection bacterial[1] In Vitro Ceftizoxime is a new parenteral cephalosporin derivative which is more active against various gram-negative bacilli, including the opportunistic pathogens such as Enterobacter, Citrobacter species, and Serratia marcescens, than cephalosporins and cephamycins such as cefotiam, cefamandole, cefuroxime, cefotaxime, and cefmetazole. Ceftizoxime shows a broad spectrum of antibacterial activity against aerobic gram-positive and gram-negative bacteria[1]. In Vivo The therapeutic effect of Ceftizoxime in mice infected with a small inoculum size is almost the same as that of cefotaxime[1]. Ceftizoxime is stable in biological fluids such as serum, urine, and tissue homogenates, but cefotaxime is unstable in rat tissue homogenates. Binding of ceftizoxime to serum protein in all species is the lowest of all the antibiotics: 31% for humans, 17% for dogs, and 32% for rats[2]. References [1]. Kamimura T, et al. Ceftizoxime (Ceftizoxime), a new parenteral cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother. 1979 Nov;16(5):540-8. [2]. Murakawa T, et al. Pharmacokinetics of ceftizoxime in animals after parenteral dosing. Antimicrob Agents Chemother. 1980 Feb;17(2):157-64. Chemical & Physical Properties Molecular Formula C13H13N5O5S2 Exact Mass 383.035797 PSA 200.75000 Index of Refraction 1.849 InChIKey NNULBSISHYWZJU-LDYMZIIASA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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