CAS Number58-94-6
SynonymsChlotride; EINECS 200-404-9; UNII:77W477J15H; MFCD00058576; chlorothiazidum; 6-chloro-1,1-dioxo-4H-1λ<sup>6</sup>,2,4-benzothiadiazine-7-sulfonamide; 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 4H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide; Diuril; Chlorothiazide
Molecular FormulaC7H6ClN3O4S2
Molecular Weight295.723
Purity98%
Density2.0±0.1 g/cm3
Boiling Point608.8±65.0 °C at 760 mmHg
Melting Point342-343°C
AppearanceWhite crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 58-94-6 |
| Catalog No. | 2A-9009751 |
| Chinese Name | 氯噻嗪 |
| Synonyms | Chlotride; EINECS 200-404-9; UNII:77W477J15H; MFCD00058576; chlorothiazidum; 6-chloro-1,1-dioxo-4H-1λ<sup>6</sup>,2,4-benzothiadiazine-7-sulfonamide; 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 4H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide; Diuril; Chlorothiazide |
| Molecular Formula | C7H6ClN3O4S2 |
| Molecular Weight | 295.723 |
| Purity | 98 |
| Density | 2.0±0.1 g/cm3 |
| Boiling Point | 608.8±65.0 °C at 760 mmHg |
| Melting Point | 342-343°C |
| Appearance | White crystalline powder |
| Water Solubility | <0.1 g/100 mL at 19.5 ºC |
| Storage Condition | This product should be sealed and stored away from |
| Application | Chlorothiazide is antihypertensive with an IC50 of 3.8 mM. |
| SMILES | NS(=O)(=O)c1cc2c(cc1Cl)NC=NS2(=O)=O |
| InChI | InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13) |
| InChI Key | JBMKAUGHUNFTOL-UHFFFAOYSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/9751_2_58_94_6.pdf |
| Bioactivity | Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM)Target: OthersChlorothiazide sodium (Diuril) is a diuretic used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. It is also used as an antihypertensive. Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism than furosemide, and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease References [1]. Pogacar PR, et al. Management of central diabetes insipidus in infancy with low renal solute load formula and chlorothiazide. Curr Opin Pediatr. 2000 Aug;12(4):405-11. Chemical & Physical Properties Density 2.0±0.1 g/cm3 Boiling Point 608.8±65.0 °C at 760 mmHg Melting Point 342-343°C Molecular Formula C7H6ClN3O4S2 Molecular Weight 295.723 Flash Point 322.0±34.3 °C Exact Mass 294.948822 PSA 135.45000 LogP -0.18 Vapour Pressure 0.0±1.7 mmHg at 25°C Index of Refraction 1.801 InChIKey JBMKAUGHUNFTOL-UHFFFAOYSA-N SMILES NS(=O)(=O)c1cc2c(cc1Cl)NC=NS2(=O)=O Storage condition 2-8°C Stability Stable. Incompatible with strong oxidizing agents. Water Solubility <0.1 g/100 mL at 19.5 ºC |
| Use of | Properties Articles28 Name chlorothiazide Synonym More Synonyms Chlorothiazide Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease References [1]. Pogacar PR, et al. Management of central diabetes insipidus in infancy with low renal solute load formula and chlorothiazide. Curr Opin Pediatr. 2000 Aug;12(4):405-11. Chemical & Physical Properties Exact Mass 294.948822 PSA 135.45000 LogP -0.18 Index of Refraction 1.801 InChIKey JBMKAUGHUNFTOL-UHFFFAOYSA-N Stability Stable. Incompatible with strong oxidizing agents. |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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