CAS Number70052-12-9
Synonyms2-(difluoromethyl)-2,5-diaminopentanoic acid; 2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-1H-imidazole hydrochloride; MFCD00242734; 2,5-diamino-2-(difluoromethyl)pentanoic acid; 2-Ethyl-2-(imidazolin-2-yl)-2,3-dihydrobenzofuran hydrochloride; Efaroxan HCl; H-DL-(a-difluoromethyl)Orn-OH; Efaroxan hydrochloride
Molecular FormulaC6H12F2N2O2
Molecular Weight182.17 (anhydrous free base basis)
Purity≥97 (NMR)%
Density1.293g/cm3
Boiling Point347ºC at 760 mmHg
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 70052-12-9 |
| Catalog No. | 2A-9010287 |
| Chinese Name | DL-Alpha-二氟甲基鸟氨酸盐酸盐 |
| Synonyms | 2-(difluoromethyl)-2,5-diaminopentanoic acid; 2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-1H-imidazole hydrochloride; MFCD00242734; 2,5-diamino-2-(difluoromethyl)pentanoic acid; 2-Ethyl-2-(imidazolin-2-yl)-2,3-dihydrobenzofuran hydrochloride; Efaroxan HCl; H-DL-(a-difluoromethyl)Orn-OH; Efaroxan hydrochloride |
| Molecular Formula | C6H12F2N2O2 |
| Molecular Weight | 182.17 (anhydrous free base basis) |
| Purity | ≥97 (NMR) |
| Density | 1.293g/cm3 |
| Boiling Point | 347ºC at 760 mmHg |
| Appearance | solid |
| Storage Condition | 2-8℃ |
| Application | Eflornithine is a specific irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medicine used to treat African trypanosomiasis and excessive facial hair growth in women. |
| PubChem ID | 24278809 |
| MDL Number | MFCD00242734 |
| SMILES | O.Cl.NCCCC(N)(C(F)F)C(O)=O |
| InChI | 1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2 |
| InChI Key | FJPAMFNRCFEGSD-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/10287_1_70052_12_9.pdf |
| Bioactivity | Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others In Vivo Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4]. Animal Admin Mice: The skin area where the hair is removed is then treated with the eflornithine hydrochloride 13.9% cream (∼50 mg per mouse per treatment) using a spatula 2 times a day in an interval of at least 8 h for a maximum period of 36 days[3]. References [1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. [2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. [3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. [4]. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312. Chemical & Physical Properties Density 1.293g/cm3 Boiling Point 347ºC at 760 mmHg Molecular Formula C6H12F2N2O2 Molecular Weight 182.16800 Flash Point 163.7ºC Exact Mass 182.08700 PSA 89.34000 LogP 1.17310 InChIKey VLCYCQAOQCDTCN-UHFFFAOYSA-N SMILES NCCCC(N)(C(=O)O)C(F)F Storage condition 2-8℃ |
| Use of | Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women. Properties Name Eflornithine Synonym More Synonyms Eflornithine Biological Activity Description Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others In Vivo Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4]. References [1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. [2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. [3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. [4]. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312. Chemical & Physical Properties Molecular Formula C6H12F2N2O2 Exact Mass 182.08700 PSA 89.34000 LogP 1.17310 InChIKey VLCYCQAOQCDTCN-UHFFFAOYSA-N SMILES NCCCC(N)(C(=O)O)C(F)F Storage condition 2-8℃ |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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