CAS Number965-52-6
SynonymsBenzoic acid, 4-hydroxy-, 2-[(1E)-(5-nitro-2-furanyl)methylene]hydrazide; Nifuroxazide; Ercefuryl; Diarlidan; Dicoferin; EINECS 213-522-0; Nifuroxazid; Nifuroxazidum; 4-Hydroxy-N'-[(E)-(5-nitro-2-furyl)methylene]benzohydrazide; Nifuroxazida; p-hydroxy-N'-(5-nitrofurfurylidene)benzhydrazide; MFCD00079482; Nifuroxazidum [INN-Latin]; Ercefurol
Molecular FormulaC12H9N3O5
Molecular Weight275.22
Purity≥97 (HPLC)%
Density1.5±0.1 g/cm3
Melting Point281-283°C
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 965-52-6 |
| Catalog No. | 2A-9011661 |
| Chinese Name | 硝呋酚酰肼 |
| Synonyms | Benzoic acid, 4-hydroxy-, 2-[(1E)-(5-nitro-2-furanyl)methylene]hydrazide; Nifuroxazide; Ercefuryl; Diarlidan; Dicoferin; EINECS 213-522-0; Nifuroxazid; Nifuroxazidum; 4-Hydroxy-N'-[(E)-(5-nitro-2-furyl)methylene]benzohydrazide; Nifuroxazida; p-hydroxy-N'-(5-nitrofurfurylidene)benzhydrazide; MFCD00079482; Nifuroxazidum [INN-Latin]; Ercefurol |
| Molecular Formula | C12H9N3O5 |
| Molecular Weight | 275.22 |
| Purity | ≥97 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Melting Point | 281-283°C |
| Appearance | solid |
| Storage Condition | Refrigerator, Under Inert Atmosphere |
| Application | Nifuroxazide is a potent inhibitor of STAT3 and has anticancer and antimetastatic activity. |
| HTC | 2928000090 |
| MDL Number | MFCD00079482 |
| SMILES | [N+](=O)([O-])c1[o]c(cc1)\C=N\NC(=O)c2ccc(cc2)O |
| InChI | 1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+ |
| InChI Key | YCWSUKQGVSGXJO-NTUHNPAUSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352125 |
| MSDS | msds/11661_1_965_52_6.pdf |
| Use of | Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity. Properties Articles28 Name 4-hydroxy-N-[(E)-(5-nitrofuran-2-yl)methylideneamino]benzamide Synonym More Synonyms Nifuroxazide Biological Activity Description Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity. Related Catalog Research Areas >> Cancer Research Areas >> Infection References [1]. Nelson EA, et al. Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. Blood. 2008 Dec 15;112(13):5095-102. [2]. Zhu Y, et al. Nifuroxazide exerts potent anti-tumor and anti-metastasis activity in melanoma. Sci Rep. 2016 Feb 2;6:20253. Chemical & Physical Properties Molecular Formula C12H9N3O5 Exact Mass 275.054230 PSA 120.65000 Index of Refraction 1.653 InChIKey YCWSUKQGVSGXJO-QPEQYQDCSA-N Storage condition Refrigerator, Under Inert Atmosphere Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Benzoic acid, p-hydroxy-, (5-nitrofurfurylidene)hydrazide CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C12-H9-N3-O5 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T5OJ BNW E1UNMVR DQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - antipsychotic Lungs, Thorax, or Respiration - respiratory depression Kidney, Ureter, Bladder - other changes in urine composition MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 187,55,1987 Safety Information Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter Hazard Codes Xi RIDADR NONH for all modes of transport WGK Germany 3 RTECS DH2528300 HS Code 2928000090 Synthetic Route Total: 1 Page 5-Nitro-2-fural... CAS#:92-55-7 4-Hydroxybenzhy... CAS#:5351-23-5 Nifuroxazide CAS#:965-52-6 Literature: Tavares; Penna; Amaral Bollettino Chimico Farmaceutico, 1997 , vol. 136, # 3 p. 244 - 249 Methyl 4-hydrox... CAS#:99-76-3 Nifuroxazide CAS#:965-52-6 Literature: Bollettino Chimico Farmaceutico, , vol. 136, # 3 p. 244 - 249 4-Hydroxybenzoi... CAS#:99-96-7 Nifuroxazide CAS#:965-52-6 Literature: Bollettino Chimico Farmaceutico, , vol. 136, # 3 p. 244 - 249 Precursor & DownStream Precursor 4 CAS#:92-55-7 5-Nitro-2-fural... CAS#:5351-23-5 4-Hydroxybenzhy... CAS#:99-76-3 Methyl 4-hydrox... CAS#:99-96-7 4-Hydroxybenzoi... DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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