CAS Number150399-21-6
SynonymsBalsalazide Disodium Salt Dihydrate; Balsalzide Disodium Hydrate; 5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic Acid Disodium Salt Dihydrate; Balsalazide disodium; Sodium 5-[(E)-{4-[(2-carboxylatoethyl)carbamoyl]phenyl}diazenyl]-2-hydroxybenzoate hydrate (2:1:2); Balsalazide (sodium hydrate)
Molecular FormulaC17H17N3Na2O8
Molecular Weight437.31
Purity98%
AppearanceYellow to orange crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 150399-21-6 |
| Catalog No. | 2A-9009299 |
| Chinese Name | 巴柳氮二钠 |
| Synonyms | Balsalazide Disodium Salt Dihydrate; Balsalzide Disodium Hydrate; 5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic Acid Disodium Salt Dihydrate; Balsalazide disodium; Sodium 5-[(E)-{4-[(2-carboxylatoethyl)carbamoyl]phenyl}diazenyl]-2-hydroxybenzoate hydrate (2:1:2); Balsalazide (sodium hydrate) |
| Molecular Formula | C17H17N3Na2O8 |
| Molecular Weight | 437.31 |
| Purity | 98 |
| Appearance | Yellow to orange crystalline powder |
| Water Solubility | Water solubility: completely soluble; very slightl |
| Storage Condition | Room temperature, dry |
| Application | Balsalazide sodium hydrate exerts relevant tumor suppressor effects by modulating the IL-6/STAT3 pathway. |
| HTC | 2853009090 |
| MDL Number | MFCD01631117 |
| SMILES | [Na+].[Na+].N(\N=C2/C=C(C(=O)C=C/2)C(=O)[O-])c1ccc(cc1)C(=O)NCCC(=O)[O-].O.O |
| InChI | 1S/C17H15N3O6.2Na.2H2O/c21-14-6-5-12(9-13(14)17(25)26)20-19-11-3-1-10(2-4-11)16(24)18-8-7-15(22)23;;;;/h1-6,9,19H,7-8H2,(H,18,24)(H,22,23)(H,25,26);;;2*1H2/q;2*+1;;/p-2/b20-12-;;;; |
| InChI Key | HYSVUPBQPCRAJM-PIFVRXTCSA-L |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/9299_1_150399_21_6.pdf |
| Bioactivity | Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology Target STAT3 IL-6 In Vivo At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2]. References [1]. Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61. [2]. Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789. Chemical & Physical Properties Molecular Formula C17H17N3Na2O8 Molecular Weight 437.312 Exact Mass 437.081116 PSA 172.77000 LogP 0.30320 |
| Use of | Properties Name Balsalazide disodium Synonym More Synonyms Balsalazide disodium Biological Activity Related Catalog Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology References Chemical & Physical Properties Molecular Formula C17H17N3Na2O8 Exact Mass 437.081116 PSA 172.77000 LogP 0.30320 |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
| Related Products in Functional Building Blocks | ||
|---|---|---|
| trans-1,4-Cyclohexanedicarboxylic acid | 619-82-9 | 2A-9008846 |
| trans-4-Isopropylcyclohexanecarboxylic acid | 7077-05-6 | 2A-9008857 |
| 4-(Trifluoromethyl)-2'-biphenylcarboxylic acid | 84392-17-6 | 2A-9008989 |
| 4-Isobutoxybenzohydrazide | 91430-26-1 | 2A-9008996 |
| Balsalazide | 80573-04-2 | 2A-9009298 |
| Cefmenoxime | 65085-01-0 | 2A-9009639 |
| Cefpodoxime | 80210-62-4 | 2A-9009664 |
| Cefpodoxime proxetil | 87239-81-4 | 2A-9009665 |
| Ceftizoxime | 68401-81-0 | 2A-9009679 |
| Ceftizoxime sodium | 68401-82-1 | 2A-9009680 |
| Browse all Functional Building Blocks products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS