CAS Number111470-99-6
SynonymsAmlodin; Norvasc; UNII:864V2Q084H; MFCD00887594; Amlodipine Besilate; Amlodipine besylate; AMLODIPINE BENZENESULFONATE
Molecular FormulaC26H31ClN2O8S
Molecular Weight567.05
Purity98%
Density1.227g/cm3
Boiling Point527.2ºC at 760 mmHg
Melting Point199-201°C
Appearancewhite powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 111470-99-6 |
| Catalog No. | 2A-9009166 |
| Chinese Name | 苯磺酸氨氯地平 |
| Synonyms | Amlodin; Norvasc; UNII:864V2Q084H; MFCD00887594; Amlodipine Besilate; Amlodipine besylate; AMLODIPINE BENZENESULFONATE |
| Molecular Formula | C26H31ClN2O8S |
| Molecular Weight | 567.05 |
| Purity | 98 |
| Density | 1.227g/cm3 |
| Boiling Point | 527.2ºC at 760 mmHg |
| Melting Point | 199-201°C |
| Appearance | white powder |
| Water Solubility | DMSO: 20 mg/mL |
| Storage Condition | Sealed and stored in a cool, dry warehouse. |
| Application | Amlodipine besylate is a long-acting calcium channel inhibitor. |
| HTC | 2933990090 |
| PubChem ID | 329823196 |
| MDL Number | MFCD00887594 |
| SMILES | OS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC |
| InChI | 1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9) |
| InChI Key | ZPBWCRDSRKPIDG-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/9166_1_111470_99_6.pdf |
| Bioactivity | Amlodipine besylate is a long-acting calcium channel blocker.Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa = 8.6), and its interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. From Wikipedia. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. http://en.wikipedia.org/wiki/Amlodipine Chemical & Physical Properties Density 1.227g/cm3 Boiling Point 527.2ºC at 760 mmHg Melting Point 199-201°C Molecular Formula C26H31ClN2O8S Molecular Weight 567.051 Flash Point 272.6ºC Exact Mass 566.148987 PSA 162.63000 LogP 5.30950 Vapour Pressure 3.34E-11mmHg at 25°C InChIKey ZPBWCRDSRKPIDG-UHFFFAOYSA-N SMILES CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl.O=S(=O)(O)c1ccccc1 Storage condition Store at RT Water Solubility DMSO: 20 mg/mL |
| Use of | Amlodipine besylate is a long-acting calcium channel blocker.Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa = 8.6), and its interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. From Wikipedia. Properties Articles61 Name amlodipine benzenesulfonate Synonym More Synonyms Amlodipine besylate Biological Activity Description Amlodipine besylate is a long-acting calcium channel blocker.Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa = 8.6), and its interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. From Wikipedia. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. http://en.wikipedia.org/wiki/Amlodipine Chemical & Physical Properties Exact Mass 566.148987 PSA 162.63000 LogP 5.30950 InChIKey ZPBWCRDSRKPIDG-UHFFFAOYSA-N Storage condition Store at RT |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| Aminophylline | 317-34-0 | 2A-9009158 |
| Amiodarone | 1951-25-3 | 2A-9009160 |
| Amiodarone hydrochloride | 19774-82-4 | 2A-9009161 |
| Amisulpride | 71675-85-9 | 2A-9009163 |
| Amlodipine | 88150-42-9 | 2A-9009165 |
| Amlodipine maleate | 88150-47-4 | 2A-9009167 |
| Amoxicillin | 26787-78-0 | 2A-9009176 |
| Amoxicillin sodium | 34642-77-8 | 2A-9009177 |
| Amoxicillin trihydrate | 61336-70-7 | 2A-9009178 |
| Anastrozole | 120511-73-1 | 2A-9009193 |
| Browse all API & Advanced Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS