CAS Number26787-78-0
SynonymsIntermox; Lamoxy; A-Gram; Novenzymin; Amoxin; Amoxtrex; AMOX; Amoxa; Imaxilin; Uro-clamoxyl; Imox; Rancil; Moxylin; Ampidroxyl; MOx; Excillin; Tolodina; Protexillin; Samosillin; Amoxy; Bridopen; Grunamox; Jerramcil; Kamoxin; Amoxaren; Zamocillin; Damoxicil; Zamocilline; Larocilin; Cilamox
Molecular FormulaC16H19N3O5S
Molecular Weight365.40
Purity95.0-102.0 anhydrous basis%
Density1.6±0.1 g/cm3
Boiling Point701.8±70.0 °C at 760 mmHg
Appearancepowder
EINECS248-003-8
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 26787-78-0 |
| Catalog No. | 2A-9009176 |
| Chinese Name | 阿莫西林 |
| Synonyms | Intermox; Lamoxy; A-Gram; Novenzymin; Amoxin; Amoxtrex; AMOX; Amoxa; Imaxilin; Uro-clamoxyl; Imox; Rancil; Moxylin; Ampidroxyl; MOx; Excillin; Tolodina; Protexillin; Samosillin; Amoxy; Bridopen; Grunamox; Jerramcil; Kamoxin; Amoxaren; Zamocillin; Damoxicil; Zamocilline; Larocilin; Cilamox |
| Molecular Formula | C16H19N3O5S |
| Molecular Weight | 365.40 |
| Purity | 95.0-102.0 anhydrous basis |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 701.8±70.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | 2-8°C |
| Application | Amoxicillin is a mid-spectrum beta-lactam antibiotic. |
| EINECS | 248-003-8 |
| HTC | 2941109200 |
| PubChem ID | 329770960 |
| MDL Number | MFCD00056860 |
| SMILES | CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(O)=O |
| InChI | 1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14-/m1/s1 |
| InChI Key | LSQZJLSUYDQPKJ-NJBDSQKTSA-N |
| Beilstein/REAXYS | 7507120 |
| NACRES Code | NA.85 |
| UNSPSC | 51102829 |
| MSDS | msds/9176_1_26787_78_0.pdf |
| Use of | Amoxicillin is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.Target: AntibacterialAmoxicillin is a moderate-spectrum, bacteriolytic, β-lactam antibiotic in the aminopenicillin family used to treat bacterial infections caused by susceptible Gram-positive and Gram-negative microorganisms. It is usually the drug of choice within the class because it is better-absorbed, following oral administration, than other β-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, which are resistant to a narrow spectrum of β-lactam antibiotics, such as penicillin. For this reason, it is often combined with clavulanic acid, a β-lactamase inhibitor. This increases effectiveness by reducing its susceptibility to β-lactamase resistance. From Wikipedia. Properties Articles364 Name amoxicillin Synonym More Synonyms Amoxicillin Biological Activity Description Amoxicillin is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.Target: AntibacterialAmoxicillin is a moderate-spectrum, bacteriolytic, β-lactam antibiotic in the aminopenicillin family used to treat bacterial infections caused by susceptible Gram-positive and Gram-negative microorganisms. It is usually the drug of choice within the class because it is better-absorbed, following oral administration, than other β-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, which are resistant to a narrow spectrum of β-lactam antibiotics, such as penicillin. For this reason, it is often combined with clavulanic acid, a β-lactamase inhibitor. This increases effectiveness by reducing its susceptibility to β-lactamase resistance. From Wikipedia. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. http://en.wikipedia.org/wiki/Amoxicillin Chemical & Physical Properties Molecular Formula C16H19N3O5S Exact Mass 365.104553 PSA 158.26000 Index of Refraction 1.745 InChIKey LSQZJLSUYDQPKJ-NJBDSQKTSA-N Stability Stable. Incompatible with strong oxidizing agents. Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl) amino)-3,3-dimethyl-7-oxo- CAS REGISTRY NUMBER : 26787-78-0 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C16-H19-N3-O5-S MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T45 ANV ESTJ CMVYZR DQ& F1 F1 GVQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - man DOSE/DURATION : TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,707,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - child DOSE/DURATION : TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume decreased Kidney, Ureter, Bladder - hematuria REFERENCE : CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 32,735,1993 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - child DOSE/DURATION : TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - other changes in urine composition REFERENCE : CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 32,735,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,38,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,38,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS REFERENCE : CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 26,196,1980 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : AGSREJ Arab Gulf Journal of Scientific Research. (Arab Bureau of Education for the Gulf States, POB 3908, Riyadh, 11481, Saudi Arabia) V.7 No.2- 1989- Volume(issue)/page/year: 12,133,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3562 No. of Facilities: 921 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 24519 (estimated) No. of Female Employees: 10563 (estimated) Safety Information Signal Word Danger Hazard Statements H317-H334 Precautionary Statements P261-P280-P342 + P311 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves Hazard Codes Xn:Harmful RIDADR NONH for all modes of transport WGK Germany 2 RTECS XH8300000 HS Code 2941109200 Synthetic Route D(-)-p-hydroxy-... 82095-48-5 N-triisopropyls... 68698-88-4 Amoxicillin 26787-78-0 Literature: Antibioticos Patent: US4193918 A1, 1980 ; 6-Aminopenicill... 2-Chloro-1,3,2-... Amoxicillin 26787-78-0 Literature: Novo Industri A/S Patent: US4202817 A1, 1980 ; oxfenicine 32462-30-9 Pivaloyl chlori... Ethyl acetoacet... 6-Aminopenicill... Literature: Antibioticos Patent: US4193918 A1, 1980 ; Precursor & DownStream Precursor 10 CAS#:82095-48-5 D(-)-p-hydroxy-... CAS#:68698-88-4 N-triisopropyls... CAS#:551-16-6 6-Aminopenicill... CAS#:822-39-9 2-Chloro-1,3,2-... DownStream 3 CAS#:34642-77-8 Amoxicillin sodium CAS#:73590-58-6 omeprazole CAS#:106-57-0 Glycine Anhydride |
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