CAS Number88150-42-9
SynonymsNorvasc; Lipinox; Amlodis; UNII:1J444QC288; Amlodipino; Istin; Amlodipinum [Latin]; Amlodipinum; Amlocard; Amlodipine; MFCD00864687; Coroval
Molecular FormulaC20H25O5N2Cl1
Molecular Weight408.88
Purity98%
Density1.2±0.1 g/cm3
Boiling Point527.2±50.0 °C at 760 mmHg
Melting Point178-179ºC
Appearanceyellow solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 88150-42-9 |
| Catalog No. | 2A-9009165 |
| Chinese Name | 氨氯地平 |
| Synonyms | Norvasc; Lipinox; Amlodis; UNII:1J444QC288; Amlodipino; Istin; Amlodipinum [Latin]; Amlodipinum; Amlocard; Amlodipine; MFCD00864687; Coroval |
| Molecular Formula | C20H25O5N2Cl1 |
| Molecular Weight | 408.88 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 527.2±50.0 °C at 760 mmHg |
| Melting Point | 178-179ºC |
| Appearance | yellow solid |
| Water Solubility | 75.3 mg/L |
| Storage Condition | -20°C Freezer |
| Application | Amlodipine is a long-acting calcium blocker. |
| HTC | 2942000000 |
| MDL Number | MFCD00864687 |
| SMILES | CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl |
| InChI | InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3 |
| InChI Key | HTIQEAQVCYTUBX-UHFFFAOYSA-N |
| MSDS | msds/9165_1_88150_42_9.pdf |
| Use of | Amlodipine is a long-acting calcium channel blocker.Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa = 8.6), and its interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. From Wikipedia. Properties Name amlodipine Synonym More Synonyms Amlodipine Biological Activity Description Amlodipine is a long-acting calcium channel blocker.Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa = 8.6), and its interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. From Wikipedia. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. http://en.wikipedia.org/wiki/Amlodipine Chemical & Physical Properties Exact Mass 408.145203 PSA 99.88000 Index of Refraction 1.546 InChIKey HTIQEAQVCYTUBX-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2942000000 Synthetic Route Amlodipine besylate CAS#:111470-99-6 Amlodipine CAS#:88150-42-9 Amlodipine inte... CAS#:88150-62-3 Amlodipine CAS#:88150-42-9 3-O-ethyl 5-O-m... CAS#:88150-46-3 Amlodipine CAS#:88150-42-9 Literature: Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702 Precursor & DownStream Precursor 7 CAS#:111470-99-6 Amlodipine besylate CAS#:88150-62-3 Amlodipine inte... CAS#:88150-46-3 3-O-ethyl 5-O-m... CAS#:638-07-3 Ethyl 2-Chloroa... DownStream 5 CAS#:88150-47-4 Amlodipine maleate CAS#:58-93-5 Hydrochlorothiazide CAS#:111470-99-6 Amlodipine besylate CAS#:103129-82-4 Levamlodipine |
| Transport Info | Product Name: Amlodipine |
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