CAS Number39831-55-5
Synonyms2-[(3-aminopropyl)amino]ethylphosphorothioic acid monohydrate; Amifostina; Amifostinum; Amikacin disulfate salt; EINECS 254-648-6; D-Streptamine; amikacin disulphate; Amikacin Sulphate; MFCD00167475; amifostine monohydrate; Amifostine hydrate; amikacin disulfate; Amikacin sulfate; Amikacin (sulfate)
Molecular FormulaC22H47N5O21S2
Molecular Weight781.76
Purity98.00%
Boiling Point981.8ºC at 760 mmHg
Melting Point220-230ºC
Appearancepowder or crystals
EINECS254-648-6
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 39831-55-5 |
| Catalog No. | 2A-9009154 |
| Chinese Name | 硫酸阿米卡星 |
| Synonyms | 2-[(3-aminopropyl)amino]ethylphosphorothioic acid monohydrate; Amifostina; Amifostinum; Amikacin disulfate salt; EINECS 254-648-6; D-Streptamine; amikacin disulphate; Amikacin Sulphate; MFCD00167475; amifostine monohydrate; Amifostine hydrate; amikacin disulfate; Amikacin sulfate; Amikacin (sulfate) |
| Molecular Formula | C22H47N5O21S2 |
| Molecular Weight | 781.76 |
| Purity | 98.00 |
| Boiling Point | 981.8ºC at 760 mmHg |
| Melting Point | 220-230ºC |
| Appearance | powder or crystals |
| Water Solubility | H2O: 50 mg/mL, clear, colorless |
| Storage Condition | Sealed, cool, dry storage |
| Application | Amikacin sulfate (BAY416651) is a semi-synthetic glucosamine antibiotic, a derivative of kanamycin A. |
| EINECS | 254-648-6 |
| HTC | 29419000 |
| PubChem ID | 24890586 |
| MDL Number | MFCD00167475 |
| SMILES | OS(O)(=O)=O.OS(O)(=O)=O.NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O |
| InChI | 1S/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;2*1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);2*(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;;/m0../s1 |
| InChI Key | FXKSEJFHKVNEFI-GCZBSULCSA-N |
| Beilstein/REAXYS | 6172633 |
| NACRES Code | NA.85 |
| UNSPSC | 51281632 |
| MSDS | msds/9154_1_39831_55_5.pdf |
| Bioactivity | Amikacin sulfate(BAY416651 sulfate) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A.Target: AntibacterialAmikacin disrupts bacterial protein synthesis by binding to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and tRNA acceptor sites leading to the production of non-functional or toxic peptides. Other mechanisms not fully understood may confer the bactericidal effects of amikacin. Amikacin is also nephrotoxic and ototoxic. Amikacin is useful against gentamicin-resistant gram-negative bacilli and also in the treatment of infections caused by susceptible Nocardia and nontuberculous mycobacteria.[1]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Edson, R.S. and C.L. Terrell, The aminoglycosides. Mayo Clin Proc, 1999. 74(5): p. 519-28. Chemical & Physical Properties Boiling Point 981.8ºC at 760 mmHg Melting Point 220-230ºC Molecular Formula C22H47N5O21S2 Molecular Weight 781.760 Exact Mass 781.220520 PSA 497.90000 InChIKey FXKSEJFHKVNEFI-LTARTOCNSA-N SMILES NCCC(O)C(=O)NC1CC(N)C(OC2OC(CN)C(O)C(O)C2O)C(O)C1OC1OC(CO)C(O)C(N)C1O.O=S(=O)(O)O.O=S(=O)(O)O Water Solubility H2O: 50 mg/mL, clear, colorless |
| Use of | Amikacin sulfate(BAY416651 sulfate) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A.Target: AntibacterialAmikacin disrupts bacterial protein synthesis by binding to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and tRNA acceptor sites leading to the production of non-functional or toxic peptides. Other mechanisms not fully understood may confer the bactericidal effects of amikacin. Amikacin is also nephrotoxic and ototoxic. Amikacin is useful against gentamicin-resistant gram-negative bacilli and also in the treatment of infections caused by susceptible Nocardia and nontuberculous mycobacteria.[1]. Properties Articles52 Name amikacin disulfate Synonym More Synonyms Amikacin sulfate Biological Activity Description Amikacin sulfate(BAY416651 sulfate) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A.Target: AntibacterialAmikacin disrupts bacterial protein synthesis by binding to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and tRNA acceptor sites leading to the production of non-functional or toxic peptides. Other mechanisms not fully understood may confer the bactericidal effects of amikacin. Amikacin is also nephrotoxic and ototoxic. Amikacin is useful against gentamicin-resistant gram-negative bacilli and also in the treatment of infections caused by susceptible Nocardia and nontuberculous mycobacteria.[1]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Edson, R.S. and C.L. Terrell, The aminoglycosides. Mayo Clin Proc, 1999. 74(5): p. 519-28. Chemical & Physical Properties Molecular Formula C22H47N5O21S2 Exact Mass 781.220520 PSA 497.90000 InChIKey FXKSEJFHKVNEFI-LTARTOCNSA-N |
| Transport Info | Product name: Amikacin sulfate |
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