CAS Number315-30-0
SynonymsUrosin; Urbol; 7H-Pyrazolo[3,4-d]pyrimidin-4-ol; Apurol; Pural; 1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; Anoprolin; HPP; Sigapurol; allopurinal; aloral; T56 BMN GN INJ FQ; Epidropal; Apurin; 4-HPP; 4-Hydroxypyrazolo[3,4-d]pyrimidine; Zyloprim; Isopurinol; AL-100; Takanarumin; 1H-Pyrazolo[3,4-d]pyrimidin-4-ol; Caplenal; Allopurinol; Remid; MFCD00599413; Bleminol; EINECS 206-250-9; Allopurin; Foligan; Anzief
Molecular FormulaC5H4N4O
Molecular Weight136.11
Purity≥99 (TLC)%
Density1.7±0.1 g/cm3
Boiling Point290.8ºC at 760 mmHg
Melting Point>300 °C (lit.)
Appearancepowder
EINECS206-250-9
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 315-30-0 |
| Catalog No. | 2A-9009113 |
| Chinese Name | 别嘌醇 |
| Synonyms | Urosin; Urbol; 7H-Pyrazolo[3,4-d]pyrimidin-4-ol; Apurol; Pural; 1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; Anoprolin; HPP; Sigapurol; allopurinal; aloral; T56 BMN GN INJ FQ; Epidropal; Apurin; 4-HPP; 4-Hydroxypyrazolo[3,4-d]pyrimidine; Zyloprim; Isopurinol; AL-100; Takanarumin; 1H-Pyrazolo[3,4-d]pyrimidin-4-ol; Caplenal; Allopurinol; Remid; MFCD00599413; Bleminol; EINECS 206-250-9; Allopurin; Foligan; Anzief |
| Molecular Formula | C5H4N4O |
| Molecular Weight | 136.11 |
| Purity | ≥99 (TLC) |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 290.8ºC at 760 mmHg |
| Melting Point | >300 °C (lit.) |
| Appearance | powder |
| Water Solubility | 0.35 g/L (25 ºC) |
| Storage Condition | Block light and store in airtight container |
| Packaging | III |
| Application | Allopurinol (Zyloprim) is a xanthine oxidase (XO) inhibitor with an IC50 of 7.82±0.12 μM. |
| EINECS | 206-250-9 |
| HTC | 2933990090 |
| PubChem ID | 24278141 |
| MDL Number | MFCD00599413 |
| SMILES | O=C1NC=Nc2[nH]ncc12 |
| InChI | 1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10) |
| InChI Key | OFCNXPDARWKPPY-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352202 |
| Hazard Symbols | 6.1 |
| MSDS | msds/9113_1_315_30_0.pdf |
| Bioactivity | Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.Target: XAOAllopurinol (Zyloprim, and generics) is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout. It is a xanthine oxidase inhibitor which is administered orally. A common misconception is that allopurinol is metabolized by its target, xanthine oxidase, but this action is principally carried out by Aldehyde oxidase. The active metabolite of allopurinol is oxypurinol, which is also an inhibitor of xanthine oxidase. Allopurinol is almost completely metabolized to oxypurinol within two hours of oral administration, whereas oxypurinol is slowly excreted by the kidneys over 18-30 hours. For this reason, oxypurinol is believed responsible for the majority of allopurinol's effect.Allopurinol is a purine analog; it is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and is an inhibitor of the enzyme xanthine oxidase. In addition to blocking uric acid production, inhibition of xanthine oxidase causes an increase in hypoxanthine and xanthine. While xanthine cannot be converted to purine ribotides, hypoxanthine can be salvaged to the purine ribotides adenosine and guanosine monophosphates. Increased levels of these ribotides may cause feedback inhibition of amidophosphoribosyl transferase, the first and rate-limiting enzyme of purine biosynthesis. Allopurinol, therefore, decreases uric acid formation and may also inhibit purine synthesis. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase Research Areas >> Metabolic Disease References [1]. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114. [2]. Reiter S, et al. Demonstration of a combined deficiency of xanthine oxidase and aldehyde oxidase in xanthinuric patients not forming oxipurinol. Clin Chim Acta. 1990 Mar 15;187(3):221-34. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 290.8ºC at 760 mmHg Melting Point 350 ºC Molecular Formula C5H4N4O Molecular Weight 136.111 Flash Point 129.7ºC Exact Mass 136.038513 PSA 74.43000 LogP -1.46 Index of Refraction 1.816 Water Solubility 0.35 g/L (25 ºC) |
| Use of | Properties Articles174 Name allopurinol Synonym More Synonyms Allopurinol Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase Research Areas >> Metabolic Disease References [1]. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114. [2]. Reiter S, et al. Demonstration of a combined deficiency of xanthine oxidase and aldehyde oxidase in xanthinuric patients not forming oxipurinol. Clin Chim Acta. 1990 Mar 15;187(3):221-34. Chemical & Physical Properties Molecular Formula C5H4N4O Exact Mass 136.038513 PSA 74.43000 LogP -1.46 Index of Refraction 1.816 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Allopurinol) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Allopurinol) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Allopurinol) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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