CAS Number120511-73-1
SynonymsAnastrozole; ICI-D-1033; ZD-1033; 2,2'-5-(1H-1,2,4-triazol-1-ylmethyl)benzene-1,3-diylbis(2-methylpropanenitrile); Anastrol; MFCD00866298; 2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropanenitrile); ICI D 1033; 1,3-benzenediacetonitrile; 2,2'-[5-(1H-1,2,4-triazol-1-ylméthyl)benzène-1,3-diyl]bis(2-méthylpropanenitrile); 2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)benzol-1,3-diyl]bis(2-methylpropanonitril); ANASTRAZOLE; 2,2'-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1,3-phenylene)bis(2-methylpropanenitrile); 4-Triazol-1-ylmethyl)-1; Anastrolozole; Anatrozole; a,a,a',a'-Tetramethyl-5-(1H-,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile; Anastrozol; ARIMIDEX
Molecular FormulaC17H19N5
Molecular Weight293.37
Purity98%
Density1.1±0.1 g/cm3
Boiling Point469.7±55.0 °C at 760 mmHg
Melting Point81-82°C
Appearancecrystalline solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 120511-73-1 |
| Catalog No. | 2A-9009193 |
| Chinese Name | 阿那曲唑 |
| Synonyms | Anastrozole; ICI-D-1033; ZD-1033; 2,2'-5-(1H-1,2,4-triazol-1-ylmethyl)benzene-1,3-diylbis(2-methylpropanenitrile); Anastrol; MFCD00866298; 2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropanenitrile); ICI D 1033; 1,3-benzenediacetonitrile; 2,2'-[5-(1H-1,2,4-triazol-1-ylméthyl)benzène-1,3-diyl]bis(2-méthylpropanenitrile); 2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)benzol-1,3-diyl]bis(2-methylpropanonitril); ANASTRAZOLE; 2,2'-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1,3-phenylene)bis(2-methylpropanenitrile); 4-Triazol-1-ylmethyl)-1; Anastrolozole; Anatrozole; a,a,a',a'-Tetramethyl-5-(1H-,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile; Anastrozol; ARIMIDEX |
| Molecular Formula | C17H19N5 |
| Molecular Weight | 293.37 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 469.7±55.0 °C at 760 mmHg |
| Melting Point | 81-82°C |
| Appearance | crystalline solid |
| Storage Condition | Store at RT |
| Packaging | III |
| Application | Anastrozole is a selective aromatase inhibitor that inhibits placental aromatase with an IC50 of 15 nM. |
| HTC | 2933990090 |
| SMILES | [n]2(ncnc2)Cc1cc(cc(c1)C(C)(C)C#N)C(C)(C)C#N |
| InChI | 1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3 |
| InChI Key | YBBLVLTVTVSKRW-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/9193_1_120511_73_1.pdf |
| Bioactivity | Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM. Related Catalog Signaling Pathways >> Others >> Aromatase Research Areas >> Cancer Target IC50: 15 nM (human aromatase)[1] In Vitro Anastrozole is a comparatively simple, achiral benzyltriazole derivative, that inhibits human placental aromatase with an IC50 of 15 nM. In the same assay it is 200 times as potent as aminoglutethimide (AG), twice as potent as 4-OHA and one third as potent as Fadrozole[1]. In Vivo Groups of eight immature (22-day-old) female rats are given androstenedione (AD) (30 mg/kg) in arachis oil s.c. daily for3 days with or without various doses of Anastrozole p.o. on day 4 the uteri are dissected, blotted and weighed. An oral dose of 0.1 mg/kg of Anastrozole given on day 2 or day 3 of the cycle completely blocked ovulation. At the same daily dosage (0.1 mg/kg), Anastrozole completely extinguished the uterotrophic activity of exogenous AD in immature rats. In male pigtailed monkeys, twice-daily oral treatment with 0.1 mg/kg and above of Anastrozole reduced circulating oestradiol concentrations by 50-60%[1]. Kinase Assay Aromatase inhibition is measured using human placental microsomes and the method of Thompson and Siiteri with Testosterone (0.5 μM) as substrate. 11-hydroxylase inhibition is determined by measuring the conversion of [1,2,6,7-3H]-ll-deoxy- cortisol to cortisol using freshly prepared mitochondria from guinea pig, dog and cow adrenal glands. Reaction products areextracted into chloroform and separated by thin layer chromatography[1]. Animal Admin Mice[1] Groups of at least eight adult female rats, housed in controlled lighting (on 06.00-20.00 h) and temperature (24±2°C) and undergoing 4-day oestrous cycles, are treated p.o. with a single dose of Anastrozole (0.01-0.1 mg/kg), Fadrozole (0.01-0.1 mg/kg) or AG (5-20 mg/kg) on day 2 at 16.00 h or day 3 at 12.00 h. The presence or absence of eggs in the oviducts on day 1 of the next cycle is then determined. Ovulation is considered blocked when no eggs are found. References [1]. Dukes M, et al. The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)--a potent, selective aromatase inhibitor. J Steroid Biochem Mol Biol. 1996 Jul;58(4):439-45. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 469.7±55.0 °C at 760 mmHg Melting Point 81-82°C Molecular Formula C17H19N5 Molecular Weight 293.366 Flash Point 237.9±31.5 °C Exact Mass 293.164032 PSA 78.29000 LogP 0.97 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.580 InChIKey YBBLVLTVTVSKRW-UHFFFAOYSA-N SMILES CC(C)(C#N)c1cc(Cn2cncn2)cc(C(C)(C)C#N)c1 Storage condition Store at RT |
| Use of | Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM. Properties Articles87 Name anastrozole Synonym More Synonyms Anastrozole Biological Activity Description Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM. Related Catalog Signaling Pathways >> Others >> Aromatase Research Areas >> Cancer IC50: 15 nM (human aromatase)[1] In Vitro Anastrozole is a comparatively simple, achiral benzyltriazole derivative, that inhibits human placental aromatase with an IC50 of 15 nM. In the same assay it is 200 times as potent as aminoglutethimide (AG), twice as potent as 4-OHA and one third as potent as Fadrozole[1]. Kinase Assay Aromatase inhibition is measured using human placental microsomes and the method of Thompson and Siiteri with Testosterone (0.5 μM) as substrate. 11-hydroxylase inhibition is determined by measuring the conversion of [1,2,6,7-3H]-ll-deoxy- cortisol to cortisol using freshly prepared mitochondria from guinea pig, dog and cow adrenal glands. Reaction products areextracted into chloroform and separated by thin layer chromatography[1]. References [1]. Dukes M, et al. The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)--a potent, selective aromatase inhibitor. J Steroid Biochem Mol Biol. 1996 Jul;58(4):439-45. Chemical & Physical Properties Molecular Formula C17H19N5 Exact Mass 293.164032 PSA 78.29000 Index of Refraction 1.580 InChIKey YBBLVLTVTVSKRW-UHFFFAOYSA-N Storage condition Store at RT |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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