CAS Number83015-26-3
SynonymsHismanal(R); [3H]-Astemizole; MFCD00865352; Laridal; (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine; Histaminos; astemizole; 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazole-2-amine; Paralergin; (gR)-N-Methyl-g-(2-methylphenoxy)benzenepropanamine; tomoxetine [INN_en]; 1-(4-fluorophenylmethyl)-N-{1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine; (R)-N-methyl-3-(2-tolyloxy)-3-(phenyl)propylamine; (-)-Tomoxetine; Tomoxetine [INN]; Retolen; Alermizol; (R)-Tomoxetine; (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine; Atomoxetine; Astemison; Astemizolum; Astemizol; Hismanal
Molecular FormulaC17H21NO
Molecular Weight291.82
Purity98%
Density1.0±0.1 g/cm3
Boiling Point389.0±37.0 °C at 760 mmHg
Appearanceliquid
EINECS200-659-6
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 83015-26-3 |
| Catalog No. | 2A-9009258 |
| Chinese Name | 托莫西汀 |
| Synonyms | Hismanal(R); [3H]-Astemizole; MFCD00865352; Laridal; (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine; Histaminos; astemizole; 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazole-2-amine; Paralergin; (gR)-N-Methyl-g-(2-methylphenoxy)benzenepropanamine; tomoxetine [INN_en]; 1-(4-fluorophenylmethyl)-N-{1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine; (R)-N-methyl-3-(2-tolyloxy)-3-(phenyl)propylamine; (-)-Tomoxetine; Tomoxetine [INN]; Retolen; Alermizol; (R)-Tomoxetine; (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine; Atomoxetine; Astemison; Astemizolum; Astemizol; Hismanal |
| Molecular Formula | C17H21NO |
| Molecular Weight | 291.82 |
| Purity | 98 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 389.0±37.0 °C at 760 mmHg |
| Appearance | liquid |
| Storage Condition | -20°C, sealed, dry |
| Application | Atomoxetine (tomoxetine) is a selective norepinephrine reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), 5-hydroxytryptamine (5-HT) and dopamine (DA) transporters, resp |
| EINECS | 200-659-6 |
| HTC | 2922299090 |
| PubChem ID | 329770640 |
| MDL Number | MFCD06410992 |
| SMILES | Cl.CNCC[C@@H](Oc1ccccc1C)c2ccccc2 |
| InChI | 1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1 |
| InChI Key | LUCXVPAZUDVVBT-UNTBIKODSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/9258_1_83015_26_3.pdf |
| Use of | Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na+ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3]. Properties Name atomoxetine Synonym More Synonyms Atomoxetine Biological Activity Description Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na+ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter References [1]. Turner M, et, al. Effects of atomoxetine on locomotor activity and impulsivity in the spontaneously hypertensive rat. Behav Brain Res. 2013 Apr 15;243:28-37. [2]. Föhr KJ, et, al. Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner. Front Pharmacol. 2021 Feb 25;12:622489. [3]. Bymaster FP, et, al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711. Chemical & Physical Properties Molecular Formula C17H21NO Exact Mass 255.162308 PSA 21.26000 Index of Refraction 1.552 InChIKey VHGCDTVCOLNTBX-QGZVFWFLSA-N Safety Information HS Code 2922299090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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