CAS Number54556-98-8
SynonymsMictonetten; Mictonorm; Propiverine hydrochloride; Propiverine Hydrochlorride; 1-Methyl-4-piperidinyl diphenyl(propoxy)acetate hydrochloride (1:1); Propiverine HCl; UNII-DC4GZD10H3; Benzeneacetic acid, α-phenyl-α-propoxy-, 1-methyl-4-piperidinyl ester, hydrochloride (1:1); 1-Methylpiperidin-4-yl diphenyl(propoxy)acetate hydrochloride (1:1)
Molecular FormulaC23H30ClNO3
Molecular Weight403.95
Purity98.00%
Boiling Point494.7ºC at 760 mmHg
Melting Point213-216ºC
Appearancewhite crystal powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 54556-98-8 |
| Catalog No. | 2A-9044226 |
| Chinese Name | 盐酸丙哌维林 |
| Synonyms | Mictonetten; Mictonorm; Propiverine hydrochloride; Propiverine Hydrochlorride; 1-Methyl-4-piperidinyl diphenyl(propoxy)acetate hydrochloride (1:1); Propiverine HCl; UNII-DC4GZD10H3; Benzeneacetic acid, α-phenyl-α-propoxy-, 1-methyl-4-piperidinyl ester, hydrochloride (1:1); 1-Methylpiperidin-4-yl diphenyl(propoxy)acetate hydrochloride (1:1) |
| Molecular Formula | C23H30ClNO3 |
| Molecular Weight | 403.95 |
| Purity | 98.00 |
| Boiling Point | 494.7ºC at 760 mmHg |
| Melting Point | 213-216ºC |
| Appearance | white crystal powder |
| Storage Condition | -20°C Freezer |
| Application | Propiverine hydrochloride is a cystospasmodic agent with calcium antagonist and anticholinergic properties. Propiverine hydrochloride is used to study overactive bladder and urinary incontinence. |
| HTC | 2933399090 |
| PubChem ID | 563310 |
| MDL Number | C23H30ClNO3 |
| SMILES | CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1.Cl |
| InChI | InChI=1S/C23H29NO3.ClH/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21;/h4-13,21H,3,14-18H2,1-2H3;1H |
| InChI Key | KFUJMHHNLGCTIJ-UHFFFAOYSA-N |
| MSDS | msds/44226_1_54556_98_8.pdf |
| Use of | Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence[1][2]. Properties Articles24 Name Propiverine Hydrochloride Synonym More Synonyms Propiverine hydrochloride Biological Activity Description Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence[1][2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease In Vitro Propiverine (10-3000 nM) inhibits the specific binding of [3H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively[2]. References [1]. Kitta T, et, al. Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats. Int Urogynecol J. 2013 Apr; 24(4): 683-8. [2]. Ito Y, et, al. Muscarinic Receptor Binding and Plasma Drug Concentration after the Oral Administration of Propiverine in Mice. Low Urin Tract Symptoms. 2010 Apr; 2(1):43-9. Chemical & Physical Properties Exact Mass 403.191437 PSA 38.77000 LogP 4.73410 InChIKey KFUJMHHNLGCTIJ-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Acetic acid, diphenylpropoxy-, 1-methyl-4-piperidyl ester, hydrochloride CAS REGISTRY NUMBER : 54556-98-8 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GEXXA8 German (East) Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #139212 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GEXXA8 German (East) Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #139212 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Liver - changes in liver weight Endocrine - changes in pituitary weight REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 15,107,1990 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 17-21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - other neonatal measures or effects REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 14(Suppl 2),221,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 17-21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical Reproductive - Effects on Newborn - delayed effects REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 14(Suppl 2),221,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 17-21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 14(Suppl 2),221,1989 Safety Information GHS05, GHS07 Signal Word Danger Hazard Statements H315-H318-H335 Precautionary Statements P261-P280-P305 + P351 + P338 Hazard Codes Xi Safety Phrases 26-39 RIDADR NONH for all modes of transport RTECS AH3297000 HS Code 2933399090 Synthetic Route Total: 1 Page 1-Methyl-4-pipe... CAS#:106-52-5 CAS#:94686-44-9 Propiverine hyd... CAS#:54556-98-8 Precursor & DownStream Precursor 1 CAS#:106-52-5 1-Methyl-4-pipe... DownStream 1 CAS#:60569-19-9 1-METHYLPIPERID... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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