CAS Number54533-85-6
SynonymsNizofenone; Ekonal; EkonN; (2-Chlorophenyl)(2-{2-[(diethylamino)methyl]-1H-imidazol-1-yl}-5-nitrophenyl)methanone; (2-Chlorophenyl)[2-[2-[(diethylamino)methyl]-1H-imidazol-1-yl]-5-nitrophenyl]methanone; Y-9179; 2'-Chloro-2-[2-[(diethylamino)methyl]imidazol-1-yl]-5-nitrobenzophenone; Midafenone
Molecular FormulaC21H21ClN4O3
Molecular Weight412.869
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point609.7±65.0 °C at 760 mmHg
Melting Point75-76°
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 54533-85-6 |
| Catalog No. | 2A-9044222 |
| Chinese Name | 尼唑苯酮 |
| Synonyms | Nizofenone; Ekonal; EkonN; (2-Chlorophenyl)(2-{2-[(diethylamino)methyl]-1H-imidazol-1-yl}-5-nitrophenyl)methanone; (2-Chlorophenyl)[2-[2-[(diethylamino)methyl]-1H-imidazol-1-yl]-5-nitrophenyl]methanone; Y-9179; 2'-Chloro-2-[2-[(diethylamino)methyl]imidazol-1-yl]-5-nitrobenzophenone; Midafenone |
| Molecular Formula | C21H21ClN4O3 |
| Molecular Weight | 412.869 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 609.7±65.0 °C at 760 mmHg |
| Melting Point | 75-76° |
| Application | Nizofenone is a neuroprotective agent that protects neurons from death following cerebral ischemia or hypoxia. Nizofenone can be used to study acute neurological diseases, such as stroke [1][2][3]. |
| HTC | 2933290090 |
| PubChem ID | 5629884 |
| SMILES | CCN(CC)Cc1nccn1-c1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1Cl |
| InChI | InChI=1S/C21H21ClN4O3.C4H4O4/c1-3-24(4-2)14-20-23-11-12-25(20)19-10-9-15(26(28)29)13-17(19)21(27)16-7-5-6-8-18(16)22;5-3(6)1-2-4(7)8/h5-13H,3-4,14H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+ |
| InChI Key | WZGBZLHGOVJDET-UHFFFAOYSA-N |
| Use of | Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke[1][2][3]. Properties Name Nizofenone Synonym More Synonyms Nizofenone Biological Activity Description Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke[1][2][3]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vitro Nizofenone (1 and 10 μM) prolongs the action potential duration of guinea-pig papillary muscle and dog Purkinje fibers[3]. Nizofenone (30 μM) suppresses the spontaneous activity of dog Purkinje fibers and guinea-pigs S-A node[3]. Nizofenone (100 μM) decreases the contractile force of guinea-pig papillary muscle[3]. Nizofenone (10 μM) inhibits the peroxidative disintegration of mitochondria (in rat brain mitochondrial suspension)[4]. Chemical & Physical Properties Exact Mass 412.130219 PSA 83.95000 Index of Refraction 1.623 InChIKey WZGBZLHGOVJDET-UHFFFAOYSA-N Safety Information HS Code 2933290090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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