CAS Number59-87-0
SynonymsNefco; 5-nitro-2-furaldehyde semicarbazone; 5-nitrofuran-2-carbaldehyde semicarbazone; NFZ; (2E)-2-[(5-Nitro-2-furyl)methylene]hydrazinecarboxamide; Nitrofural; Chixin; NF-7; 5-nitro-furfural semicarbazone; Mammex; U-6421; 5-nitro-2-furfurylidenesemicarbazone; acutol; Nitrofurazone; 5-nitro-furan-2-carbaldehyde semicarbazone; (5-nitro-2-furfurylideneamino)urea; 2-Furaldehyde, 5-nitro-, semicarbazone; 5-Nitro-2-furfuraldehyde semicarbazone; Amifur; NFS; MFCD00003225; Furacilin; EINECS 200-443-1
Molecular FormulaC6H6N4O4
Molecular Weight198.14
Purity95.00%
Density1.7±0.1 g/cm3
Boiling Point236-240ºC
Melting Point242-244 °C (lit.)
AppearanceWhite to light yellow crystal powder
EINECS200-443-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 59-87-0 |
| Catalog No. | 2A-9016823 |
| Chinese Name | 呋喃西林 |
| Synonyms | Nefco; 5-nitro-2-furaldehyde semicarbazone; 5-nitrofuran-2-carbaldehyde semicarbazone; NFZ; (2E)-2-[(5-Nitro-2-furyl)methylene]hydrazinecarboxamide; Nitrofural; Chixin; NF-7; 5-nitro-furfural semicarbazone; Mammex; U-6421; 5-nitro-2-furfurylidenesemicarbazone; acutol; Nitrofurazone; 5-nitro-furan-2-carbaldehyde semicarbazone; (5-nitro-2-furfurylideneamino)urea; 2-Furaldehyde, 5-nitro-, semicarbazone; 5-Nitro-2-furfuraldehyde semicarbazone; Amifur; NFS; MFCD00003225; Furacilin; EINECS 200-443-1 |
| Molecular Formula | C6H6N4O4 |
| Molecular Weight | 198.14 |
| Purity | 95.00 |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 236-240ºC |
| Melting Point | 242-244 °C (lit.) |
| Appearance | White to light yellow crystal powder |
| Water Solubility | <0.1 g/100 mL at 19 ºC |
| Storage Condition | 5-Nitrofurfural is prepared from furfural through |
| Packaging | III |
| Application | Nitrofural is a bactericidal compound. |
| EINECS | 200-443-1 |
| HTC | 2934999090 |
| PubChem ID | 329823204 |
| MDL Number | MFCD00003225 |
| SMILES | NC(=O)N\N=C\c1ccc(o1)[N+]([O-])=O |
| InChI | 1S/C6H6N4O4/c7-6(11)9-8-3-4-1-2-5(14-4)10(12)13/h1-3H,(H3,7,9,11)/b8-3+ |
| InChI Key | IAIWVQXQOWNYOU-FPYGCLRLSA-N |
| Beilstein/REAXYS | 86403 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| Risk Codes | R22 |
| Safety Description | S36 |
| MSDS | msds/16823_1_59_87_0.pdf |
| Bioactivity | Nitrofural is a bactericidal compound used as an antibiotic most commonly in the form of ointments.Target: AntibacterialNitrofurazone, a nitroaromatic drug, is a broad spectrum antibiotic which has until now been considered as activated in bacteria by nitroreductases. Its use in medicine has become less frequent as safer and more effective products have become available, and it has been discontinued in the US.Nitrofurazone (NF) and its derivative, hydroxymethylnitrofurazone (NFOH), have presented antichagasic activity. In vitro cruzain inhibition tests were performed for both compounds, and the 50% inhibitory concentration (IC50) for NF and NFOH presented values of 22.83 ± 1.2 μM and 10.55 ± 0.81 μM, respectively. AM1 semi-empirical molecular modeling studies were performed to understand the activity of the compounds, corroborating the observed cruzain inhibitory activity. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Ryan A, et al. Activation of nitrofurazone by azoreductases: multiple activities in one enzyme. Sci Rep. 2011;1:63. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 236-240ºC Melting Point 242-244 °C(lit.) Molecular Formula C6H6N4O4 Molecular Weight 198.136 Flash Point 2 °C Exact Mass 198.038910 PSA 126.44000 LogP -0.36 Index of Refraction 1.674 InChIKey IAIWVQXQOWNYOU-FPYGCLRLSA-N SMILES NC(=O)NN=Cc1ccc([N+](=O)[O-])o1 Water Solubility <0.1 g/100 mL at 19 ºC |
| Use of | Properties Articles35 Name nitrofurazone Synonym More Synonyms Nitrofurazone Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Ryan A, et al. Activation of nitrofurazone by azoreductases: multiple activities in one enzyme. Sci Rep. 2011;1:63. Chemical & Physical Properties Molecular Formula C6H6N4O4 Exact Mass 198.038910 PSA 126.44000 LogP -0.36 Index of Refraction 1.674 InChIKey IAIWVQXQOWNYOU-FPYGCLRLSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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