CAS Number59-46-1
Synonyms4-aminobenzoic acid 2-diethylaminoethyl ester; 2-(Diethylamino)ethyl 4-aminobenzoate; Procaine Base; EINECS 200-426-9; β-(Diethylamino)ethyl p-aminobenzoate; Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester; Procaine; Benzoic acid, p-amino-, 2- (diethylamino)ethyl ester; β-Diethylaminoethyl 4-aminobenzoate; Benzoic acid, 4-amino-, 2- (diethylamino)ethyl ester; 4-Aminobenzoic acid 2-(diethylamino)ethyl ester; MFCD00007893; 2-(Diethylamino)ethyl p-aminobenzoate
Molecular FormulaC13H20N2O2
Molecular Weight236.310
Purity98.00%
Density1.1±0.1 g/cm3
Boiling Point373.6±22.0 °C at 760 mmHg
Melting Point61ºC
AppearanceSolid;White to Almost white powder to crystal
EINECS200-426-9
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 59-46-1 |
| Catalog No. | 2A-9016814 |
| Chinese Name | 奴夫卡因 |
| Synonyms | 4-aminobenzoic acid 2-diethylaminoethyl ester; 2-(Diethylamino)ethyl 4-aminobenzoate; Procaine Base; EINECS 200-426-9; β-(Diethylamino)ethyl p-aminobenzoate; Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester; Procaine; Benzoic acid, p-amino-, 2- (diethylamino)ethyl ester; β-Diethylaminoethyl 4-aminobenzoate; Benzoic acid, 4-amino-, 2- (diethylamino)ethyl ester; 4-Aminobenzoic acid 2-(diethylamino)ethyl ester; MFCD00007893; 2-(Diethylamino)ethyl p-aminobenzoate |
| Molecular Formula | C13H20N2O2 |
| Molecular Weight | 236.310 |
| Purity | 98.00 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 373.6±22.0 °C at 760 mmHg |
| Melting Point | 61ºC |
| Appearance | Solid;White to Almost white powder to crystal |
| Water Solubility | Soluble in: ether, methanol, benzene, chloroform |
| Storage Condition | room temperature, sealed |
| Packaging | III |
| Application | Procaine can exert local anesthetic activity through multiple targets. |
| EINECS | 200-426-9 |
| HTC | 2922499100 |
| SMILES | CCN(CC)CCOC(=O)c1ccc(N)cc1 |
| InChI | InChI=1S/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3 |
| InChI Key | MFDFERRIHVXMIY-UHFFFAOYSA-N |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/16814_1_59_46_1.pdf |
| Bioactivity | Procaine is a local anesthetic drug of the amino ester group, which acts through multiple targets.Target: OthersProcaine is a local anesthetic of the ester type that has a slow onset and a short duration of action.Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM [1]. Procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands. Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest [2]. Procaine functions as an excitant of limbic system cells, and that procaine alters synaptic transmission in some, but not all, output pathways from the amygdale [3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Fan, P. and F.F. Weight, Procaine impairs the function of 5-HT3 receptor-ion channel complex in rat sensory ganglion neurons. Neuropharmacology, 1994. 33(12): p. 1573-9. [2]. Villar-Garea, A., et al., Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res, 2003. 63(16): p. 4984-9. [3]. Adamec, R.E. and C. Stark-Adamec, The effects of procaine HCl on population cellular and evoked response activity within the limbic system of the cat. Evidence for differential excitatory action of procaine in a variety of limbic circuits. Prog Neuropsychopharmacol Biol Psychiatry, 1987. 11(4): p. 345-64. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 373.6±22.0 °C at 760 mmHg Melting Point 61ºC Molecular Formula C13H20N2O2 Molecular Weight 236.310 Flash Point 179.8±22.3 °C Exact Mass 236.152481 PSA 55.56000 LogP 2.36 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.543 InChIKey MFDFERRIHVXMIY-UHFFFAOYSA-N SMILES CCN(CC)CCOC(=O)c1ccc(N)cc1 |
| Use of | Properties Name procaine Synonym More Synonyms Procaine Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Fan, P. and F.F. Weight, Procaine impairs the function of 5-HT3 receptor-ion channel complex in rat sensory ganglion neurons. Neuropharmacology, 1994. 33(12): p. 1573-9. [2]. Villar-Garea, A., et al., Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res, 2003. 63(16): p. 4984-9. [3]. Adamec, R.E. and C. Stark-Adamec, The effects of procaine HCl on population cellular and evoked response activity within the limbic system of the cat. Evidence for differential excitatory action of procaine in a variety of limbic circuits. Prog Neuropsychopharmacol Biol Psychiatry, 1987. 11(4): p. 345-64. Chemical & Physical Properties Molecular Formula C13H20N2O2 Exact Mass 236.152481 PSA 55.56000 Index of Refraction 1.543 InChIKey MFDFERRIHVXMIY-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | P. Quarantine of entry animals, plants, and animal and plant products Q. Quarantine of exit animals, plants, and animal and plant products R. Hygiene supervision and inspection of imported food S. Hyg |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified Procaine Modification Number: 4 |
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