CAS Number59-32-5
SynonymsChlorneoantergan; Avapena; Halopyramine; Anaphylline; Suprastin; Synpen; N-[(4-chlorophenyl)methyl]-N-[2-(dimethylamino)ethyl]pyridin-2-amine; Synopen; N-(4-Chlor-benzyl)-N',N'-dimethyl-N-<2>pyridyl-ethylendiamin; N-[(4-chlorophenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine; Chloropyramine; Chlorpyraminum; N-(4-Chlor-benzyl)-N',N'-dimethyl-N-[2]pyridyl-aethylendiamin; Chlorpyramine; N-(4-chloro-benzyl)-N',N'-dimethyl-N-[2]pyridyl-ethylenediamine; EINECS 200-421-1
Molecular FormulaC16H20ClN3
Molecular Weight326.26
Purity98.00%
Density1.158g/cm3
Boiling Point413.5ºC at 760 mmHg
Melting Point25°C
EINECS228-216-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 59-32-5 |
| Catalog No. | 2A-9016808 |
| Chinese Name | 氯吡拉敏 |
| Synonyms | Chlorneoantergan; Avapena; Halopyramine; Anaphylline; Suprastin; Synpen; N-[(4-chlorophenyl)methyl]-N-[2-(dimethylamino)ethyl]pyridin-2-amine; Synopen; N-(4-Chlor-benzyl)-N',N'-dimethyl-N-<2>pyridyl-ethylendiamin; N-[(4-chlorophenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine; Chloropyramine; Chlorpyraminum; N-(4-Chlor-benzyl)-N',N'-dimethyl-N-[2]pyridyl-aethylendiamin; Chlorpyramine; N-(4-chloro-benzyl)-N',N'-dimethyl-N-[2]pyridyl-ethylenediamine; EINECS 200-421-1 |
| Molecular Formula | C16H20ClN3 |
| Molecular Weight | 326.26 |
| Purity | 98.00 |
| Density | 1.158g/cm3 |
| Boiling Point | 413.5ºC at 760 mmHg |
| Melting Point | 25°C |
| Storage Condition | 2-8°C |
| Application | Chloropyramide is a competitive reversible H1 receptor antagonist. Chloropyramide also has antitumor activity against breast cancer. Chloropyramide can be used to study allergic diseases, such as conj |
| EINECS | 228-216-2 |
| PubChem ID | 329774916 |
| MDL Number | MFCD00079009 |
| SMILES | Cl.CN(C)CCN(Cc1ccc(Cl)cc1)c2ccccn2 |
| InChI | 1S/C16H20ClN3.ClH/c1-19(2)11-12-20(16-5-3-4-10-18-16)13-14-6-8-15(17)9-7-14;/h3-10H,11-13H2,1-2H3;1H |
| InChI Key | VEYWWAGBHABATA-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/16808_1_59_32_5.pdf |
| Bioactivity | Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Target H1 Receptor In Vitro Chloropyramine (25, 50 μM; 24 h, 48 h) induces SASH1 expression and apoptosis in breast cancer cell lines[1]. Western Blot Analysis[1] Cell Line: Breast cancer cell lines Concentration: 25 or 50 μM Incubation Time: 24 h Result: Increased SASH1 expression in breast cancer cell lines. Apoptosis Analysis[1] Cell Line: T47D, MDA-MB-231 and BT-54 cells Concentration: 50 μM Incubation Time: 48 h Result: Induced apoptosis in breast cancer cell lines. In Vivo Chloropyramine (i.p.; 10 mg/kg) abolishes hypothermia in rats[2]. Animal Model: Rats[2] Dosage: 10 mg/kg Administration: Intraperitoneal Result: Reduced histamine-induced hypothermia. Chemical & Physical Properties Density 1.158g/cm3 Boiling Point 413.5ºC at 760 mmHg Melting Point 25°C Molecular Formula C16H20ClN3 Molecular Weight 289.80300 Flash Point 203.9ºC Exact Mass 289.13500 PSA 19.37000 LogP 3.30320 Index of Refraction 1.6 InChIKey ICKFFNBDFNZJSX-UHFFFAOYSA-N SMILES CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1 Storage condition 2-8°C |
| Use of | Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma[1][2]. Properties Name N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine Synonym More Synonyms Chloropyramine Biological Activity Description Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor H1 Receptor Chemical & Physical Properties Exact Mass 289.13500 PSA 19.37000 LogP 3.30320 Index of Refraction 1.6 InChIKey ICKFFNBDFNZJSX-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| D(+)-Xylose | 58-86-6 | 2A-9016793 |
| Lindane | 58-89-9 | 2A-9016794 |
| D-alpha-Tocopheryl acetate | 58-95-7 | 2A-9016797 |
| D-Galactose | 59-23-4 | 2A-9016805 |
| 2-Quinolinol | 59-31-4 | 2A-9016807 |
| Mepyramine maleate | 59-33-6 | 2A-9016809 |
| Procaine | 59-46-1 | 2A-9016814 |
| Chlorocresol | 59-50-7 | 2A-9016817 |
| DL-Methionine | 59-51-8 | 2A-9016818 |
| Prosultiamine | 59-58-5 | 2A-9016820 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS