CAS Number60-23-1
Synonymsb-MEA; 2-Aminoethanethiol; Thioethanolamine; β-aminoethylthiol; β-mercaptoethylamine; Mercamine; MEA; mercaptoethylamine; mercaptamine; b-Aminoethylthiol; Merkamin; b-Aminoethanethiol; Mercaptamin; 2-mercaptoethylamine; b-Mercaptoethylamine; MFCD00008196; cysteamine; Decarboxycysteine; β-Aminoethanethiol; EINECS 200-463-0
Molecular FormulaNH2CH2CH2SH
Molecular Weight77.15
Purity~95%
Density1.0±0.1 g/cm3
Boiling Point133.6±23.0 °C at 760 mmHg
Melting Point95°C
Appearancesolid
EINECS200-463-0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 60-23-1 |
| Catalog No. | 2A-9016835 |
| Chinese Name | β-巯基乙胺 |
| Synonyms | b-MEA; 2-Aminoethanethiol; Thioethanolamine; β-aminoethylthiol; β-mercaptoethylamine; Mercamine; MEA; mercaptoethylamine; mercaptamine; b-Aminoethylthiol; Merkamin; b-Aminoethanethiol; Mercaptamin; 2-mercaptoethylamine; b-Mercaptoethylamine; MFCD00008196; cysteamine; Decarboxycysteine; β-Aminoethanethiol; EINECS 200-463-0 |
| Molecular Formula | NH2CH2CH2SH |
| Molecular Weight | 77.15 |
| Purity | ~95 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 133.6±23.0 °C at 760 mmHg |
| Melting Point | 95°C |
| Appearance | solid |
| Water Solubility | Water solubility: soluble; soluble in: alcohol; ve |
| Storage Condition | This product should be sealed and stored in a cool |
| Application | Cysteamine is an antioxidant that can act on nephrotic cystinosis. |
| EINECS | 200-463-0 |
| PubChem ID | 57654428 |
| MDL Number | MFCD00008196 |
| SMILES | NCCS |
| InChI | 1S/C2H7NS/c3-1-2-4/h4H,1-3H2 |
| InChI Key | UFULAYFCSOUIOV-UHFFFAOYSA-N |
| Beilstein/REAXYS | 635649 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/16835_1_60_23_1.pdf |
| Bioactivity | Cysteamine is an agent for the treatment of nephropathic cystinosis and an antioxidant.Target: OthersCysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death [1]. Cysteamine (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes [2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6. [2]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 133.6±23.0 °C at 760 mmHg Melting Point 95°C Molecular Formula C2H7NS Molecular Weight 77.149 Flash Point 34.6±22.6 °C Exact Mass 77.029922 PSA 64.82000 LogP 0.03 Vapour Pressure 8.4±0.2 mmHg at 25°C Index of Refraction 1.486 InChIKey UFULAYFCSOUIOV-UHFFFAOYSA-N SMILES NCCS Stability Stable, but may be air-sensitive. Incompatible with strong oxidizing agents. |
| Use of | Properties Articles122 Name cysteamine Synonym More Synonyms 2-Aminoethanethiol Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6. [2]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92. Chemical & Physical Properties Molecular Formula C2H7NS Exact Mass 77.029922 PSA 64.82000 Index of Refraction 1.486 InChIKey UFULAYFCSOUIOV-UHFFFAOYSA-N SMILES NCCS Stability Stable, but may be air-sensitive. Incompatible with strong oxidizing agents. |
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