CAS Number51-05-8
Synonymscetain; Procaine (hydrochloride); Procaine hydrochloride; Jenacaine; novocaine hydrochloride; Procaine, hydrochloride; procaine HCl; ethocaine; 2-(Diethylamino)ethyl-4-aminobenzolcarboxylathydrochlorid; eugerase; Isocaine-Asid; Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, hydrochloride (1:1); MFCD00007893; 2-(Diethylamino)ethyl-4-aminobenzoathydrochlorid; 2-(Diethylamino)ethyl 4-aminobenzoate hydrochloride (1:1); 4-Aminobenzoic Acid 2-(Diethylamino)ethyl Ester Hydrochloride; naucaine; Alocaine; 2-(diethylamino)ethyl 4-aminobenzoate hydrochloride; EINECS 200-077-2; Bernacaine; anestil; anadolor; p-aminobenzoyldiethylaminoethanol hydrochloride; paracain; irocaine; 2-Diethylaminoethyl 4-aminobenzoate hydrochloride; syncaine; 4-Aminobenzoate de 2-(diéthylamino)éthyle chlorhydrate
Molecular FormulaH2NC6H4CO2CH2CH2N(C2H5)2·HCl
Molecular Weight272.77
Purity≥97%
Boiling Point195-196°C 17mm
Melting Point155-156 °C (lit.)
Appearancepowder
EINECS200-077-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 51-05-8 |
| Catalog No. | 2A-9016590 |
| Chinese Name | 盐酸普鲁卡因 |
| Synonyms | cetain; Procaine (hydrochloride); Procaine hydrochloride; Jenacaine; novocaine hydrochloride; Procaine, hydrochloride; procaine HCl; ethocaine; 2-(Diethylamino)ethyl-4-aminobenzolcarboxylathydrochlorid; eugerase; Isocaine-Asid; Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, hydrochloride (1:1); MFCD00007893; 2-(Diethylamino)ethyl-4-aminobenzoathydrochlorid; 2-(Diethylamino)ethyl 4-aminobenzoate hydrochloride (1:1); 4-Aminobenzoic Acid 2-(Diethylamino)ethyl Ester Hydrochloride; naucaine; Alocaine; 2-(diethylamino)ethyl 4-aminobenzoate hydrochloride; EINECS 200-077-2; Bernacaine; anestil; anadolor; p-aminobenzoyldiethylaminoethanol hydrochloride; paracain; irocaine; 2-Diethylaminoethyl 4-aminobenzoate hydrochloride; syncaine; 4-Aminobenzoate de 2-(diéthylamino)éthyle chlorhydrate |
| Molecular Formula | H2NC6H4CO2CH2CH2N(C2H5)2·HCl |
| Molecular Weight | 272.77 |
| Purity | ≥97 |
| Boiling Point | 195-196°C 17mm |
| Melting Point | 155-156 °C (lit.) |
| Appearance | powder |
| Water Solubility | soluble |
| Storage Condition | This product should be sealed and stored away from |
| Packaging | III |
| Application | Procaine hydrochloride has local anesthetic activity. |
| EINECS | 200-077-2 |
| HTC | 2922499100 |
| UN(IATA) | UN 2811 |
| PubChem ID | 24278665 |
| MDL Number | MFCD00013000 |
| SMILES | Cl.CCN(CC)CCOC(=O)c1ccc(N)cc1 |
| InChI | 1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H |
| InChI Key | HCBIBCJNVBAKAB-UHFFFAOYSA-N |
| Beilstein/REAXYS | 3917802 |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1 |
| Risk Codes | R25;R36/37/38 |
| Safety Description | S26;S37/39;S45 |
| MSDS | msds/16590_1_51_05_8.pdf |
| Bioactivity | Procaine Hydrochloride is a local anesthetic drug of the amino ester group.Target: OthersProcaine is a local anesthetic of the ester type that has a slow onset and a short duration of action.Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM [1]. Procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands. Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest [2]. Procaine functions as an excitant of limbic system cells, and that procaine alters synaptic transmission in some, but not all, output pathways from the amygdale [3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Fan, P. and F.F. Weight, Procaine impairs the function of 5-HT3 receptor-ion channel complex in rat sensory ganglion neurons. Neuropharmacology, 1994. 33(12): p. 1573-9. [2]. Villar-Garea, A., et al., Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res, 2003. 63(16): p. 4984-9. [3]. Adamec, R.E. and C. Stark-Adamec, The effects of procaine HCl on population cellular and evoked response activity within the limbic system of the cat. Evidence for differential excitatory action of procaine in a variety of limbic circuits. Prog Neuropsychopharmacol Biol Psychiatry, 1987. 11(4): p. 345-64. Chemical & Physical Properties Boiling Point 195-196°C 17mm Melting Point 155-156 °C(lit.) Molecular Formula C13H21ClN2O2 Molecular Weight 272.771 Flash Point 195-196°C/17mm Exact Mass 272.129150 PSA 55.56000 LogP 3.15060 InChIKey HCBIBCJNVBAKAB-UHFFFAOYSA-N SMILES CCN(CC)CCOC(=O)c1ccc(N)cc1.Cl Stability Stable. Incompatible with strong oxidizing agents. Water Solubility soluble |
| Use of | Properties Articles40 Name Procaine hydrochloride Synonym More Synonyms Procaine hydrochloride Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Fan, P. and F.F. Weight, Procaine impairs the function of 5-HT3 receptor-ion channel complex in rat sensory ganglion neurons. Neuropharmacology, 1994. 33(12): p. 1573-9. [2]. Villar-Garea, A., et al., Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res, 2003. 63(16): p. 4984-9. [3]. Adamec, R.E. and C. Stark-Adamec, The effects of procaine HCl on population cellular and evoked response activity within the limbic system of the cat. Evidence for differential excitatory action of procaine in a variety of limbic circuits. Prog Neuropsychopharmacol Biol Psychiatry, 1987. 11(4): p. 345-64. Chemical & Physical Properties Exact Mass 272.129150 PSA 55.56000 LogP 3.15060 InChIKey HCBIBCJNVBAKAB-UHFFFAOYSA-N Stability Stable. Incompatible with strong oxidizing agents. Water Solubility soluble |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | P. Quarantine of entry animals, plants, and animal and plant products Q. Quarantine of exit animals, plants, and animal and plant products R. Hygiene supervision and inspection of imported food S. Hyg |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Procaine hydrochloride) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Procaine hydrochloride) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Procaine hydrochloride) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available If applicable, the chemical meets the requirements of the Regulations on the Safety Management of Hazardous Chemicals (adopted by the State Council on January 9, 2002). |
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