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L(-)-Epinephrine

Name: L(-)-Epinephrine
Brand: 2A Biotech
SKU: 2A-9016604

CAS Number51-43-4

SynonymsEpipen; L(-)-Epinephrine; 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol; 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]benzol-1,2-diol; l-Epinephrine; (R)-Epinephrine; Lyodrin; 4-[(1R)-1-hydroxy-2-(méthylamino)éthyl]benzène-1,2-diol; Ana-Kit; Epifrin; (-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol; Corisol; L-Methylaminoethanolcatechol; Adrine; (-)-Adrenalin; (−)-Adrenalin; (−)-Epinephrine; adrenaline; R-(-)-Epinephrine; L-Adrenaline; (R)-(-)-adrenaline; (-)-adrenaline; L-Epinehphrine; MFCD00002204; Bosmin; L-Epinephine; 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol; (-)-Epinephrine; (R)-adrenaline; (-)-3,4-Dihydroxy-a-[(methylamino)methyl]benzyl Alcohol

Molecular FormulaC9H13NO3

Molecular Weight183.20 (free base basis)

Purity≥95 (TLC)%

Density1.3±0.1 g/cm3

Boiling Point413.1±40.0 °C at 760 mmHg

Melting Point208-211ºC

Appearancesolid

EINECS200-098-7

MSDSChinese English

Symbol

Signal WordWarning

Cat. No.: 2A-9016604 Purity: ≥95 (TLC)%

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Quality Control of [ 51-43-4 ] Purity: ≥95 (TLC)% SDS Specification MoL

Chemical & Physical Properties
CAS Number	51-43-4
Catalog No.	2A-9016604
Chinese Name	肾上腺素
Synonyms	Epipen; L(-)-Epinephrine; 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol; 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]benzol-1,2-diol; l-Epinephrine; (R)-Epinephrine; Lyodrin; 4-[(1R)-1-hydroxy-2-(méthylamino)éthyl]benzène-1,2-diol; Ana-Kit; Epifrin; (-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol; Corisol; L-Methylaminoethanolcatechol; Adrine; (-)-Adrenalin; (−)-Adrenalin; (−)-Epinephrine; adrenaline; R-(-)-Epinephrine; L-Adrenaline; (R)-(-)-adrenaline; (-)-adrenaline; L-Epinehphrine; MFCD00002204; Bosmin; L-Epinephine; 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol; (-)-Epinephrine; (R)-adrenaline; (-)-3,4-Dihydroxy-a-[(methylamino)methyl]benzyl Alcohol
Molecular Formula	C9H13NO3
Molecular Weight	183.20 (free base basis)
Purity	≥95 (TLC)
Density	1.3±0.1 g/cm3
Boiling Point	413.1±40.0 °C at 760 mmHg
Melting Point	208-211ºC
Appearance	solid
Storage Condition	Store in a cool, cool place filled with nitrogen a
Packaging	II
Application	L-Epinephrine is a hormone secreted by the adrenal medulla. It is an alpha-adrenergic and beta-adrenergic receptor agonist.
EINECS	200-098-7
HTC	2922509090
UN(IATA)	UN 2811
MDL Number	MFCD00035077
SMILES	N(C[C@H](O)c1cc(c(cc1)O)O)C.O[C@H]([C@@H](O)C(=O)O)C(=O)O
InChI	1S/C9H13NO3.C4H6O6/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;5-1(3(7)8)2(6)4(9)10/h2-4,9-13H,5H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1
InChI Key	YLXIPWWIOISBDD-NDAAPVSOSA-N
NACRES Code	NA.77
UNSPSC	12352200
Hazard Symbols	6.1
Risk Codes	R23/24/25;R33;R36/37/38;R52/53
MSDS	msds/16604_1_51_43_4.pdf
Bioactivity	L-Epinephrine is a hormone secreted by the medulla of the adrenal glands. L-Epinephrine is an α-adrenergic and β-adrenergic receptor agonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease Natural Products >> Others Target Human Endogenous Metabolite In Vivo A 25 microliter volume of a 1-% L-epinephrine borate solution applied on the cornea of one eye in 12 monkeys reduces blood flow through the iris and the ciliary body by 59% and 20%, respectively, compared to the untreated control eyes[1]. Epinephrine is a direct-acting sympathomimetic α-adrenergic and β-adrenergic agonist with cyclic adenosine monophosphate-mediated, complex, bidirectional pharmacologic effects on many target organs[2]. In young adult rats, endogenous release of epinephrine facilitates stable memory formation for temporally associated events. Epinephrine enhances memory in young adult rats, in part, by increasing blood glucose levels needed to modulate memory[3]. Epinephrine is the primary drug administered during cardiopulmonary resuscitation (CPR) to reverse cardiac arrest. Epinephrine increases arterial blood pressure and coronary perfusion during CPR via alpha-1-adrenoceptor agonist effects[4]. Animal Admin Rats: For the immunohistochemistry experiments, rats receive an immediate post-training subcutaneous injection of saline (0.9%), glucose (250 mg/kg), or epinephrine (0.1 mg/kg) and are then returned to the holding cage[3]. References [1]. Alm A, et al. The effect of topical l-epinephrine on regional ocular blood flow in monkeys. Invest Ophthalmol Vis Sci. 1980 May;19(5):487-91. [2]. Simons FE, et al. First-aid treatment of anaphylaxis to food: focus on epinephrine. J Allergy Clin Immunol. 2004 May;113(5):837-44. [3]. Morris KA, et al. Epinephrine and glucose modulate training-related CREB phosphorylation in old rats: relationships to age-related memory impairments. Exp Gerontol. 2013 Feb;48(2):115-27. [4]. Callaway CW, et al. Epinephrine for cardiac arrest. Curr Opin Cardiol. 2013 Jan;28(1):36-42. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 413.1±40.0 °C at 760 mmHg Melting Point 208-211ºC Molecular Formula C9H13NO3 Molecular Weight 183.204 Flash Point 207.9±17.9 °C Exact Mass 183.089539 PSA 72.72000 LogP -0.63 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.608
Use of	L-Epinephrine is a hormone secreted by the medulla of the adrenal glands. L-Epinephrine is an α-adrenergic and β-adrenergic receptor agonist. Properties Articles216 Name (R)-adrenaline Synonym More Synonyms Adrenaline Biological Activity Description L-Epinephrine is a hormone secreted by the medulla of the adrenal glands. L-Epinephrine is an α-adrenergic and β-adrenergic receptor agonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease Natural Products >> Others Human Endogenous Metabolite References [1]. Alm A, et al. The effect of topical l-epinephrine on regional ocular blood flow in monkeys. Invest Ophthalmol Vis Sci. 1980 May;19(5):487-91. [2]. Simons FE, et al. First-aid treatment of anaphylaxis to food: focus on epinephrine. J Allergy Clin Immunol. 2004 May;113(5):837-44. [3]. Morris KA, et al. Epinephrine and glucose modulate training-related CREB phosphorylation in old rats: relationships to age-related memory impairments. Exp Gerontol. 2013 Feb;48(2):115-27. [4]. Callaway CW, et al. Epinephrine for cardiac arrest. Curr Opin Cardiol. 2013 Jan;28(1):36-42. Chemical & Physical Properties Molecular Formula C9H13NO3 Exact Mass 183.089539 PSA 72.72000 LogP -0.63 Index of Refraction 1.608
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L(-)-Epinephrine

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