CAS Number124832-26-4
Synonyms2-{[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]oxy}ethyl L-valinate; L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester; L-Valine 2-(guanin-9-ylmethoxy)ethyl ester; Valacyclovir; Valtrex; 2-[(2-amino-6-hydroxy-9H-purin-9-yl)methoxy]ethyl L-valinate; L-valine, 2-[(2-amino-6-hydroxy-9H-purin-9-yl)methoxy]ethyl ester; Valaciclovir; L-Valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester; 2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl L-valinate
Molecular FormulaC13H20N6O4
Molecular Weight360.80
Purity98%
Density1.5±0.1 g/cm3
AppearanceWhite to off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 124832-26-4 |
| Catalog No. | 2A-9012898 |
| Chinese Name | 伐昔洛韦 |
| Synonyms | 2-{[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]oxy}ethyl L-valinate; L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester; L-Valine 2-(guanin-9-ylmethoxy)ethyl ester; Valacyclovir; Valtrex; 2-[(2-amino-6-hydroxy-9H-purin-9-yl)methoxy]ethyl L-valinate; L-valine, 2-[(2-amino-6-hydroxy-9H-purin-9-yl)methoxy]ethyl ester; Valaciclovir; L-Valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester; 2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl L-valinate |
| Molecular Formula | C13H20N6O4 |
| Molecular Weight | 360.80 |
| Purity | 98 |
| Density | 1.5±0.1 g/cm3 |
| Appearance | White to off-white crystalline powder |
| Storage Condition | 2-8℃ |
| Application | Valacyclovir is an antiviral compound with an IC50 of 2.9 μg/ml against HSV-1 W. |
| HTC | 3002909099 |
| PubChem ID | 329831181 |
| MDL Number | MFCD01861507 |
| SMILES | Cl.CC(C)[C@H](N)C(=O)OCCOCn1cnc2C(=O)NC(N)=Nc12 |
| InChI | 1S/C13H20N6O4.ClH/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20;/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20);1H/t8-;/m0./s1 |
| InChI Key | ZCDDBUOENGJMLV-QRPNPIFTSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/12898_1_124832_26_4.pdf |
| Use of | Properties Name valacyclovir Synonym More Synonyms Valacyclovir Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection References [1]. Valacyclovir. New indication: for genital herpes, simpler administration. Can Fam Physician. 1999 Jul;45:1698-700, 1703-5. [2]. Lycke J, Malmestr?m C, St?hle L. Acyclovir levels in serum and cerebrospinal fluid after oral administration of valacyclovir. Antimicrob Agents Chemother. 2003 Aug;47(8):2438-41. [3]. Comparison of efficacies of famciclovir and valaciclovir against herpes simplex virus type 1 in a murineimmunosuppression model. Antimicrob Agents Chemother. 1995 May;39(5):1114-9. [4]. Dhaliwal DK, Romanowski EG, Yates KA, Valacyclovir inhibits recovery of ocular HSV-1 after experimental reactivation by excimer laser keratectomy. Cornea. 1999 Nov;18(6):693-9. [5]. Guo A, Hu P, Balimane PV, Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line.J Pharmacol Exp Ther. 1999 Apr;289(1):448-54. Chemical & Physical Properties Molecular Formula C13H20N6O4 Exact Mass 324.154602 PSA 151.14000 LogP -0.88 Index of Refraction 1.673 InChIKey HDOVUKNUBWVHOX-QMMMGPOBSA-N Storage condition 2-8℃ Safety Information Hazard Codes Xi: Irritant; Safety Phrases 26-36 HS Code 3002909099 Synthetic Route Total: 1 Page Cbz-Valacyclovir CAS#:124832-31-1 Valacyclovir CAS#:124832-26-4 Literature: US4957924 A1, ; Precursor & DownStream Precursor 1 CAS#:124832-31-1 Cbz-Valacyclovir DownStream 3 CAS#:72-18-4 CAS#:124832-27-5 Valacyclovir hy... CAS#:847670-62-6 2-[(2-amino-6-o... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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