| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5611-51-8 |
| Catalog No. | 2A-9012811 |
| Chinese Name | 己曲安奈德 |
| Synonyms | Aristospan (TN); Tiamcinoloni hexacetonidum [INN]; EINECS 227-031-4; UNII-I7GT1U99Y9; TATBA; Lederspan; Triamcinolone esacetonide [DCIT] |
| Molecular Formula | C30H41FO7 |
| Molecular Weight | 532.64 |
| Purity | 98.00 |
| Density | 1.24 g/cm3 |
| Boiling Point | 619.5ºC |
| Storage Condition | Warehouse Ventilation Low Temperature Drying |
| Application | Triamcinolone hexacetonide is a commonly used long-acting steroid used to treat subacute and chronic inflammatory joint diseases. |
| SMILES | F[C@@]21[C@H]([C@H]4[C@@]([C@@]5(OC(O[C@@H]5C4)(C)C)C(=O)COC(=O)CC(C)(C)C)(C[C@@H]2O)C)CCC3=CC(=O)C=C[C@@]31C |
| InChI | 1S/C30H41FO7/c1-25(2,3)15-24(35)36-16-22(34)30-23(37-26(4,5)38-30)13-20-19-9-8-17-12-18(32)10-11-27(17,6)29(19,31)21(33)14-28(20,30)7/h10-12,19-21,23,33H,8-9,13-16H2,1-7H3/t19-,20-,21-,23+,27-,28-,29-,30+/m0/s1 |
| InChI Key | TZIZWYVVGLXXFV-FLRHRWPCSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/12811_1_5611_51_8.pdf |
| Bioactivity | Triamcinolone hexacetonide is a commonly used long-acting steroids in treatment of subacute and chronic inflammatory joint diseases. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology In Vivo Triamcinolone hexacetonide produces a marked, dose-dependent protective effect in the model of chemically induced articular cartilage damage. Guinea pig injected with Triamcinolone hexacetonide shows much less prominent fibrillation and osteophytes. Cell loss is less extensive. A single injection of Triamcinolone hexacetonide into the ipsilateral knee of rabbits which have been subjected to partial lateral meniscectomy and transection of the sesamoid and collateral fibular ligaments reduces chondrocyte cloning, loss of cells, osteophyte formation, and fibrillation[1]. The half-life of commercially available Triamcinolone hexacetonide in the vitreous is double that of Triamcinolone hexacetonide, but the former is toxic to the retina in this rabbit model. Reformulated iso-osmolar Triamcinolone hexacetonide shows no evidence of deleterious effects to retina function or structure[2]. Local application of Triamcinolone hexacetonide at a site of lingual nerve injury leads to changes that are potentially beneficial such as reduced mechanical sensitivity and enhanced regeneration[3]. Animal Admin Guinea pigs: Animals are given intraarticular injection of 0.1 mL of Triamcinolone hexacetonide provided a dose of 0.40 mg/kg (groups 2 and 3) or 0.04 mg/kg (groups 4 and 5). The volume of CMC injected into the knees of group 6 animals is the same as that used for the intraarticular injections in the other groups, i.e., 0.1 mL. When the animals are killed, both knees are immediately opened and examined grossly[1]. References [1]. Williams JM, et al. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Arthritis Rheum. 1985 Nov;28(11):1267-74. [2]. Abd-El-Barr MM, et al. Safety and pharmokinetics of triamcinolone hexacetonide in rabbit eyes. J Ocul Pharmacol Ther. 2008 Apr;24(2):197-205. [3]. Yates JM, et al. The effect of triamcinolone hexacetonide on the spontaneous and mechanically-induced ectopic discharge following lingual nerve injury in the ferret. Pain. 2004 Oct;111(3):261-9. Chemical & Physical Properties Density 1.24 g/cm3 Boiling Point 619.5ºC Molecular Formula C30H41FO7 Molecular Weight 532.64100 Flash Point 328.5ºC Exact Mass 532.28400 PSA 99.13000 LogP 4.40590 Index of Refraction 1.556 InChIKey TZIZWYVVGLXXFV-FLRHRWPCSA-N SMILES CC(C)(C)CC(=O)OCC(=O)C12OC(C)(C)OC1CC1C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C |
| Use of | Triamcinolone hexacetonide is a commonly used long-acting steroids in treatment of subacute and chronic inflammatory joint diseases. Properties Articles28 Name triamcinolone hexacetonide Synonym More Synonyms Triamcinolone hexacetonide Biological Activity Description Triamcinolone hexacetonide is a commonly used long-acting steroids in treatment of subacute and chronic inflammatory joint diseases. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology References [1]. Williams JM, et al. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Arthritis Rheum. 1985 Nov;28(11):1267-74. [2]. Abd-El-Barr MM, et al. Safety and pharmokinetics of triamcinolone hexacetonide in rabbit eyes. J Ocul Pharmacol Ther. 2008 Apr;24(2):197-205. [3]. Yates JM, et al. The effect of triamcinolone hexacetonide on the spontaneous and mechanically-induced ectopic discharge following lingual nerve injury in the ferret. Pain. 2004 Oct;111(3):261-9. Chemical & Physical Properties Molecular Formula C30H41FO7 Exact Mass 532.28400 PSA 99.13000 LogP 4.40590 Index of Refraction 1.556 InChIKey TZIZWYVVGLXXFV-FLRHRWPCSA-N |
| Transport Info | Product name: Triamcinolone acetonide |
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