| Chemical & Physical Properties | |
|---|---|
| CAS Number | 119413-54-6 |
| Catalog No. | 2A-9012780 |
| Chinese Name | 盐酸拓扑替康 |
| Synonyms | MFCD00866235; 9-[(Dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin |
| Molecular Formula | C23H24O5N3Cl1 |
| Molecular Weight | 457.91 |
| Purity | 98 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 782.9±60.0 °C at 760 mmHg |
| Melting Point | 213-218ºC |
| Appearance | White crystalline solid |
| Storage Condition | Refrigerator |
| Application | Topotecan Hydrochloride (SKF 104864A; NSC 609669) is a topoisomerase I inhibitor with anticancer activity. |
| HTC | 2942000000 |
| MDL Number | MFCD00866235 |
| SMILES | CCC1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3c(CN(C)C)c(O)ccc3nc2-1.Cl |
| InChI | InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1 |
| InChI Key | DGHHQBMTXTWTJV-BQAIUKQQSA-N |
| MSDS | msds/12780_1_119413_54_6.pdf |
| Use of | Topotecan Hydrochloride (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor with potent antineoplastic activities. Properties Name Topotecan HCl Synonym More Synonyms Topotecan hydrochloride Biological Activity Description Topotecan Hydrochloride (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor with potent antineoplastic activities. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Cancer Topoisomerase I References [1]. Zhang FL, et al. PLoS One. 2013 Nov 26;8(11):e81815.Topoisomerase I inhibitors, Shikonin and Topotecan, inhibit growth and induce apoptosis of glioma cells andglioma stem cells. [2]. Kumar S, et al. Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res. 2011 Sep 1;17(17):5656-67. Chemical & Physical Properties Exact Mass 421.163757 PSA 104.89000 Index of Refraction 1.734 InChIKey DGHHQBMTXTWTJV-BQAIUKQQSA-N Storage condition Refrigerator Safety Information Hazard Codes T: Toxic; Risk Phrases R25 HS Code 2942000000 Synthetic Route Dichloromethane (S)-10-Hydroxyc... 19685-09-7 Dimethylamine Topotecan hydro... 119413-54-6 Literature: US6660861 B1, ; Page column 5 ; (S)-10-Hydroxyc... 19685-09-7 Dimethylamine Dibromomethane Topotecan hydro... 119413-54-6 Literature: US6660861 B1, ; Page column 5 ; Diiodomethane (S)-10-Hydroxyc... 19685-09-7 Dimethylamine Topotecan hydro... 119413-54-6 Precursor & DownStream Precursor 9 CAS#:75-09-2 Dichloromethane CAS#:19685-09-7 (S)-10-Hydroxyc... CAS#:124-40-3 Dimethylamine CAS#:74-95-3 Dibromomethane DownStream 0 |
| Transport Info | Product Name: Topotecan Hydrochloride |
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