| Chemical & Physical Properties | |
|---|---|
| CAS Number | 139404-48-1 |
| Catalog No. | 2A-9012741 |
| Chinese Name | 噻托溴铵 |
| Synonyms | MFCD00867027; Tiotropium bromide hydrate; Tiotropium bromide monohydrate; Tiotropium bromide xhydrate; Tiotropium (bromide hydrate) |
| Molecular Formula | C19H24BrNO5S2 |
| Molecular Weight | 490.432 |
| Purity | 99 |
| Melting Point | 218-220ºC |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | Tiotropium Bromide hydrate is a long-acting muscarinic receptor antagonist. |
| HTC | 2934999090 |
| SMILES | C[N+]1(C)C2CC(OC(=O)C(O)(c3cccs3)c3cccs3)CC1C1OC12.O.[Br-] |
| InChI | InChI=1S/C19H22NO4S2.BrH/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;/h3-8,11-13,16-17,22H,9-10H2,1-2H3;1H/q+1;/p-1/t11?,12-,13+,16+,17-; |
| InChI Key | MQLXPRBEAHBZTK-KFEMZTBUSA-M |
| Use of | Tiotropium Bromide hydrate is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.Target: mAChRTiotropium bromide (Ba 679 BR) is a novel potent and long-lasting muscarinic antagonist that has been developed for the treatment of chronic obstructive airways disease (COPD). Binding studies with [3H]tiotropium bromide in human lung have confirmed that this is a potent muscarinic antagonist with equal affinity for M1-, M2- and M3-receptors and is approximately 10-fold more potent than ipratropium bromide. In vitro tiotropium bromide has a potent inhibitory effect against cholinergic nerve-induced contraction of guinea-pig and human airways, that has a slower onset than atropine or ipratropium bromide. tiotropium bromide dissociates slowly from M3-receptors (on airway smooth muscle) but rapidly from M2 autoreceptors (on cholinergic nerve terminals) [1]. Tiotropium bromide is a quaternary ammonium derivative that binds to muscarinic receptors. However, although tiotropium binds with high affinity to muscarinic receptors of M1-, M2- and M3-subtypes, it dissociates very slowly from M1- and M3-receptors but more rapidly from M2-receptors, thereby giving it a unique kinetic selectivity [2]. Properties Name Tiotropium Bromide Synonym More Synonyms Tiotropium bromide hydrate Biological Activity Description Tiotropium Bromide hydrate is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.Target: mAChRTiotropium bromide (Ba 679 BR) is a novel potent and long-lasting muscarinic antagonist that has been developed for the treatment of chronic obstructive airways disease (COPD). Binding studies with [3H]tiotropium bromide in human lung have confirmed that this is a potent muscarinic antagonist with equal affinity for M1-, M2- and M3-receptors and is approximately 10-fold more potent than ipratropium bromide. In vitro tiotropium bromide has a potent inhibitory effect against cholinergic nerve-induced contraction of guinea-pig and human airways, that has a slower onset than atropine or ipratropium bromide. tiotropium bromide dissociates slowly from M3-receptors (on airway smooth muscle) but rapidly from M2 autoreceptors (on cholinergic nerve terminals) [1]. Tiotropium bromide is a quaternary ammonium derivative that binds to muscarinic receptors. However, although tiotropium binds with high affinity to muscarinic receptors of M1-, M2- and M3-subtypes, it dissociates very slowly from M1- and M3-receptors but more rapidly from M2-receptors, thereby giving it a unique kinetic selectivity [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease References [1]. Barnes, P.J., et al., Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease. Life Sci, 1995. 56(11-12): p. 853-9. [2]. Hansel, T.T. and P.J. Barnes, Tiotropium bromide: a novel once-daily anticholinergic bronchodilator for the treatment of COPD. Drugs Today (Barc), 2002. 38(9): p. 585-600. Chemical & Physical Properties Molecular Formula C19H24BrNO5S2 Exact Mass 489.027924 PSA 124.77000 InChIKey MQLXPRBEAHBZTK-KFEMZTBUSA-M Storage condition -20℃ Safety Information RIDADR NONH for all modes of transport HS Code 2934999090 Synthetic Route 7-(2,2-dithioph... CAS#:1336913-22-4 Tiotropium brom... CAS#:139404-48-1 Scopine Di(2-th... CAS#:136310-64-0 Methyl bromide CAS#:74-83-9 Tiotropium brom... CAS#:139404-48-1 5,5-di(thiophen... CAS#:1374772-94-7 Scopine Methobromide CAS#:1508-46-9 Tiotropium brom... CAS#:139404-48-1 Precursor & DownStream Precursor 9 CAS#:1336913-22-4 7-(2,2-dithioph... CAS#:136310-64-0 Scopine Di(2-th... CAS#:74-83-9 Methyl bromide CAS#:1374772-94-7 5,5-di(thiophen... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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