CAS Number136310-93-5
SynonymsTiova; MFCD00867027; BA 679 BR; 6b,7b-Epoxy-3b-hydroxy-8-methyl-1aH,5aH-tropanium bromide di-2-thienylglycolate; Spiriva Handihaler; TIOTROPIUM BROMIDE; Spiriva; Tiotropium (Bromide)
Molecular FormulaC19H22BrNO4S2
Molecular Weight490.43
Purity99%
Melting Point218-2200C
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 136310-93-5 |
| Catalog No. | 2A-9012740 |
| Chinese Name | 噻托溴铵 |
| Synonyms | Tiova; MFCD00867027; BA 679 BR; 6b,7b-Epoxy-3b-hydroxy-8-methyl-1aH,5aH-tropanium bromide di-2-thienylglycolate; Spiriva Handihaler; TIOTROPIUM BROMIDE; Spiriva; Tiotropium (Bromide) |
| Molecular Formula | C19H22BrNO4S2 |
| Molecular Weight | 490.43 |
| Purity | 99 |
| Melting Point | 218-2200C |
| Appearance | white solid |
| Water Solubility | Water solubility: Practically insoluble; soluble i |
| Storage Condition | Refrigerator |
| Application | Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of acetylcholine ligands. |
| HTC | 29309070 |
| MDL Number | MFCD23704176 |
| SMILES | [H]O[H].O=C(C(C1=C([H])C([H])=C([H])S1)(O[H])C2=C([H])C([H])=C([H])S2)O[C@@]3([H])C([H])([H])[C@@]4([H])[C@@]5([H])[C@@](O5)([H])[C@](C3([H])[H])([H])[N+]4(C([H])([H])[H])C([H])([H])[H].[Br-] |
| InChI | 1S/C19H22NO4S2.BrH.H2O/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;;/h3-8,11-13,16-17,22H,9-10H2,1-2H3;1H;1H2/q+1;;/p-1/t11?,12-,13+,16?,17?;; |
| InChI Key | MQLXPRBEAHBZTK-YQMLGFMRSA-M |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/12740_1_136310_93_5.pdf |
| Use of | Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. Properties Name Tiotropium Bromide Synonym More Synonyms Tiotropium bromide Biological Activity Description Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. Related Catalog Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease In Vitro Tiotropium Bromide stops signaling between neurons and leads to muscle relaxation. Tiotropium Bromide is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease. Tiotropium Bromide improves symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure. References [1]. Barnes PJ. Tiotropium bromide. Expert Opin Investig Drugs. 2001 Apr;10(4):733-40. [2]. ZuWallack AR, ZuWallack RL. Tiotropium bromide, a new, once-daily inhaled anticholinergic bronchodilator for chronic-obstructive pulmonary disease. Expert Opin Pharmacother. 2004 Aug;5(8):1827-35. [3]. Lipson DA. Tiotropium bromide. Int J Chron Obstruct Pulmon Dis. 2006;1(2):107-14. [4]. Mamary AJ, Criner GJ. Tiotropium bromide for chronic obstructive pulmonary disease. Expert Rev Respir Med. 2009 Jun;3(3):211-20. [5]. Szmidt M. [The influence of treatment with formoterol, formoterol with tiotropium, formoterol with inhaled glucocorticosteroid and tiotropium on lung functions, tolerance of exercise and simple, morning everyday activities in patients with chronic obstructive pulmonary disease (COPD)]. Pneumonol Alergol Pol. 2012;80(3):255-62. Chemical & Physical Properties Molecular Formula C19H22BrNO4S2 Exact Mass 471.017365 PSA 115.54000 InChIKey DQHNAVOVODVIMG-RGECMCKFSA-M Storage condition Refrigerator Safety Information Hazard Codes Xi Risk Phrases R36:Irritating to the eyes. WGK Germany 3 HS Code 29309070 |
| Transport Info | Product name: Tiotropium bromide |
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