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Tenofovir disoproxil structure, CAS 202138-50-9

Tenofovir disoproxil

CAS Number202138-50-9

SynonymsGS-4331-05; Viread (TN); Tenofovir diisoproxil fuMarate; Tenofovir disoproxil fumarate; Viread; TENOFOVIR DISOPROXIC; Tenofovir DF; 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine Fumarate; Tenofovir (Disoproxil Fumarate)

Molecular FormulaC23H34N5O14P

Molecular Weight635.51

Purity98%

Density1.45 g/cm3

Boiling Point642.7ºC at 760 mmHg

Melting Point219ºC

Flash Point

AppearanceWhite to pink crystal

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Cat. No.: 2A-9012626 Purity: 98%
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Quality Control of [ 202138-50-9 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number202138-50-9
Catalog No.2A-9012626
Chinese Name富马酸替诺福韦酯
SynonymsGS-4331-05; Viread (TN); Tenofovir diisoproxil fuMarate; Tenofovir disoproxil fumarate; Viread; TENOFOVIR DISOPROXIC; Tenofovir DF; 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine Fumarate; Tenofovir (Disoproxil Fumarate)
Molecular FormulaC23H34N5O14P
Molecular Weight635.51
Purity98
Density1.45 g/cm3
Boiling Point642.7ºC at 760 mmHg
Melting Point219ºC
AppearanceWhite to pink crystal
Storage ConditionRefrigerator
ApplicationTenofovir Disoproxil Fumarate is a nucleotide reverse transcriptase inhibitor used to treat HIV and chronic hepatitis B.
HTC2933990090
MDL NumberMFCD08141829
SMILESOC(/C=C/C(O)=O)=O.NC1=C2C(N(C[C@@H](C)OCP(OCOC(OC(C)C)=O)(OCOC(OC(C)C)=O)=O)C=N2)=NC=N1
InChI1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1
InChI KeyVCMJCVGFSROFHV-WZGZYPNHSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/12626_1_202138_50_9.pdf
Use ofTenofovir Disoproxil Fumarate is a nucleotide reverse transcriptase inhibitor used to treat HIV and chronic Hepatitis B. Properties Name tenofovir disoproxil fumarate Synonym More Synonyms Tenofovir Disoproxil Fumarate Biological Activity Description Tenofovir Disoproxil Fumarate is a nucleotide reverse transcriptase inhibitor used to treat HIV and chronic Hepatitis B. Related Catalog Signaling Pathways >> Anti-infection >> HBV Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection References [2]. Musumeci G, et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018 [3]. Wahl A, et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098 [4]. Menne S, Cote PJ, Korba BE, Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8. [5]. Xu P, et al. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692. Chemical & Physical Properties Molecular Formula C23H34N5O14P Exact Mass 635.183960 PSA 269.85000 LogP 3.32860 InChIKey VCMJCVGFSROFHV-PFEQFJNWSA-N Storage condition Refrigerator Safety Information Signal Word Danger Hazard Statements H318 Precautionary Statements P280-P305 + P351 + P338 + P310 Hazard Codes Xi Safety Phrases 26-36 RIDADR NONH for all modes of transport HS Code 2933990090 Synthetic Route Chloromethyl is... CAS#:35180-01-9 fumaric acid CAS#:110-17-8 CAS#:147127-20-6 Tenofovir Disop... CAS#:202138-50-9 tenofovir disop... CAS#:1215085-38-3 fumaric acid CAS#:110-17-8 Tenofovir Disop... CAS#:202138-50-9 (R)-(+)-9-(2-Hy... CAS#:14047-28-0 Tenofovir Disop... CAS#:202138-50-9 Literature: Organic Process Research and Development, , vol. 14, # 5 p. 1194 - 1201 Precursor & DownStream Precursor 7 CAS#:35180-01-9 Chloromethyl is... CAS#:110-17-8 fumaric acid CAS#:147127-20-6 CAS#:1215085-38-3 tenofovir disop... DownStream 0
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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