CAS Number147127-20-6
Synonyms(R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid; (R)-(1-(6-amino-9H-purin-9-yl)propan-2-yloxy)methylphosphonic acid; D,L-TENOFOVIR; Apropovir; 9-Pmpa; MFCD07357269; Tenefovir; GS-1278; 1-(6-Aminopurin-9-yl)propan-2-yloxymethylphosphonic acid
Molecular FormulaC9H14N5O4P
Molecular Weight287.21
Purity≥98 (HPLC)%
Density1.8±0.1 g/cm3
Boiling Point616.1±65.0 °C at 760 mmHg
Melting Point276-280°C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 147127-20-6 |
| Catalog No. | 2A-9012625 |
| Chinese Name | 泰诺福韦 |
| Synonyms | (R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid; (R)-(1-(6-amino-9H-purin-9-yl)propan-2-yloxy)methylphosphonic acid; D,L-TENOFOVIR; Apropovir; 9-Pmpa; MFCD07357269; Tenefovir; GS-1278; 1-(6-Aminopurin-9-yl)propan-2-yloxymethylphosphonic acid |
| Molecular Formula | C9H14N5O4P |
| Molecular Weight | 287.21 |
| Purity | ≥98 (HPLC) |
| Density | 1.8±0.1 g/cm3 |
| Boiling Point | 616.1±65.0 °C at 760 mmHg |
| Melting Point | 276-280°C |
| Appearance | powder |
| Water Solubility | 13.4 mg/mL (25 ºC) |
| Storage Condition | Store at -20°C |
| Packaging | III |
| Application | Tenofovir is a nucleotide reverse transcriptase inhibitor used to treat HIV and chronic hepatitis B. |
| HTC | 2933990090 |
| PubChem ID | 329826070 |
| MDL Number | MFCD00943794 |
| SMILES | OP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)(O)=O |
| InChI | 1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1 |
| InChI Key | SGOIRFVFHAKUTI-ZCFIWIBFSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| Hazard Symbols | 8 |
| MSDS | msds/12625_1_147127_20_6.pdf |
| Use of | Tenofovir is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B. Properties Name Tenofovir Synonym More Synonyms Tenofovir Biological Activity Description Tenofovir is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B. Related Catalog Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection References [2]. Musumeci G, et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018. [3]. Wahl A, et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098. [4]. Menne S, Cote PJ, Korba BE, Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8. Chemical & Physical Properties Molecular Formula C9H14N5O4P Exact Mass 287.078339 PSA 146.19000 LogP -1.71 Index of Refraction 1.740 InChIKey SGOIRFVFHAKUTI-ZCFIWIBFSA-N Safety Information Hazard Codes C Risk Phrases R34:Causes burns. WGK Germany 3 RTECS DB8930000 Packaging Group III Hazard Class 8 HS Code 2933990090 Synthetic Route bis(2-propyl) (... 160616-04-6 147127-20-6 Literature: Jansa, Petr; Baszczynski, Ondrej; Prochazkova, Eliska; Dracinsky, Martin; Janeba, Zlatko Green Chemistry, 2012 , vol. 14, # 8 p. 2282 - 2288 (R)-9-[2-(DIETH... 180587-75-1 147127-20-6 Diethyl tosylox... 31618-90-3 (R)-(+)-9-(2-Hy... 14047-28-0 147127-20-6 Precursor & DownStream Precursor 9 CAS#:180587-75-1 (R)-9-[2-(DIETH... CAS#:31618-90-3 Diethyl tosylox... CAS#:14047-28-0 (R)-(+)-9-(2-Hy... CAS#:17435-30-2 (R)-1-((5-amino... DownStream 2 CAS#:202138-50-9 Tenofovir Disop... CAS#:379270-37-8 Tenofovir alafe... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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