CAS Number10540-29-1
Synonyms[3H]-Tamoxifen; EINECS 234-118-0; trans-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine; Valodex; 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine; (Z)-1-{4-[2-(dimethylamino)ethoxy]-phenyl}-1,2-diphenyl-1-butene; Tamoxen; 2-{4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy}-N,N-dimethylethanamine; cis-Tamoxifen; Tamizam; Istubal; Oncomox; Soltamox; Crisafeno; Citofen; Tamoxifen; Diemon; MFCD00010454; Tamoxifene; 2YR&UYR&R DO2N1&1 &&Z Form; (Z)-2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine; [Z]-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine; 1-p-b-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene; 2-{4-[(1Z)-1,2-Diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine; Zemide
Molecular FormulaC6H5C(C2H5)=C(C6H5)C6H4OCH2CH2N(CH3)2
Molecular Weight371.51
Purity≥99%
Density1.0±0.1 g/cm3
Boiling Point482.3±33.0 °C at 760 mmHg
Melting Point97-98 °C (lit.)
AppearanceFine off-white crystalline powder
EINECS234-118-0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 10540-29-1 |
| Catalog No. | 2A-9012574 |
| Chinese Name | 他莫昔芬 |
| Synonyms | [3H]-Tamoxifen; EINECS 234-118-0; trans-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine; Valodex; 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine; (Z)-1-{4-[2-(dimethylamino)ethoxy]-phenyl}-1,2-diphenyl-1-butene; Tamoxen; 2-{4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy}-N,N-dimethylethanamine; cis-Tamoxifen; Tamizam; Istubal; Oncomox; Soltamox; Crisafeno; Citofen; Tamoxifen; Diemon; MFCD00010454; Tamoxifene; 2YR&UYR&R DO2N1&1 &&Z Form; (Z)-2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine; [Z]-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine; 1-p-b-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene; 2-{4-[(1Z)-1,2-Diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine; Zemide |
| Molecular Formula | C6H5C(C2H5)=C(C6H5)C6H4OCH2CH2N(CH3)2 |
| Molecular Weight | 371.51 |
| Purity | ≥99 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 482.3±33.0 °C at 760 mmHg |
| Melting Point | 97-98 °C (lit.) |
| Appearance | Fine off-white crystalline powder |
| Storage Condition | Seal in a cool, dry place at 4°C. |
| Application | Tamoxifen is a selective estrogen receptor modulator (SERM) that blocks the effects of estrogen in breast cells and activates estrogenic activity in other cells, such as bone, liver and uterine cells. |
| EINECS | 234-118-0 |
| HTC | 2922199090 |
| PubChem ID | 24900307 |
| MDL Number | MFCD00010454 |
| SMILES | CC\C(c1ccccc1)=C(/c2ccccc2)c3ccc(OCCN(C)C)cc3 |
| InChI | 1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25- |
| InChI Key | NKANXQFJJICGDU-QPLCGJKRSA-N |
| NACRES Code | NA.54 |
| UNSPSC | 12161501 |
| Hazard Symbols | Transport |
| MSDS | msds/12574_1_10540_29_1.pdf |
| Bioactivity | Tamoxifen is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer Target Estrogen receptor[1] In Vitro Tamoxifen shows strong inhibition of MCF-7 cells (EC50=1.41 μM) and to a lesser extent the T47D cells (EC50=2.5 μM) but does not affect the MDA-MB-231 cells[2]. In Vivo The Tamoxifen-inducible gene knockout strategy has clear advantages in that expression of a gene can be ablated in adult mice at will in a tissue specific manner. To study the role of Med1 in adult heart, 7-week old TmcsMed1-/- mice are given a daily Iintraperitoneal injection of Tamoxifen at a dose of 65 mg/kg for 5 days and killed at selected intervals thereafter. qPCR analysis of RNA shows that the Med1 expression begin to decrease after 3 days of Tamoxifen injection (about 70% decrease), and by 5 days of injection, Med1 expression is almost non-detectable in the heart. Tamoxifen-inducible cardiac-specific disruption of Med1 (TmcsMed1-/-) in adult mice causes dilated cardiomyopathy[3]. Animal Admin Mice[3] Seven-week old TmcsMed1-/- mice and the wild-type littermates are then administered Tamoxifen intraperitoneally at a daily dose of 65 mg/kg body weight for 5 days and then killed at selected intervals after initiation of Tamoxifen treatment. For each experiment 3 to 5 mice for control and csMed1-/- are used. To obtain survival curve 41 csMed1-/- and 41 csMed1fl/fl mice are used. Thirteen TmcsMed-/- mice and the same number of littermates are used for the survival curve experiments using Tamoxifen inducible model. The specific criteria for animal euthanasia included absence of food or water intake, slow or no mobility, weak or absence of heart beat, absence of palpitation of the chest as well as absence of respiratory movement. Mice are euthanized by intraperitoneal pentobarbital injection at the dose of 150mg/kg body weight to minimize suffering. References [1]. Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998 Nov 26;339(22):1609-18. [2]. Hawariah A, et al. In vitro response of human breast cancer cell lines to the growth-inhibitory effects of styrylpyrone derivative (SPD) and assessment of its antiestrogenicity. Anticancer Res. 1998 Nov-Dec;18(6A):4383-6. [3]. Jia Y, et al. Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal DilatedCardiomyopathy in Mice. PLoS One. 2016 Aug 22;11(8):e0160755. [4]. Wang Y, et al. Evaluation of the safety and tolerability of tamoxifen for ischemia-incited renal injury in mice. Am J Transl Res. 2018 Jul 15;10(7):2184-2194. eCollection 2018. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 482.3±33.0 °C at 760 mmHg Melting Point 97-98ºC Molecular Formula C26H29NO Molecular Weight 371.515 Flash Point 140.0±27.7 °C Exact Mass 371.224915 PSA 12.47000 LogP 7.88 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.582 InChIKey NKANXQFJJICGDU-QPLCGJKRSA-N SMILES CCC(=C(c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 Storage condition 2-8°C |
| Use of | Tamoxifen is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Properties Articles646 Name tamoxifen Synonym More Synonyms Tamoxifen Biological Activity Description Tamoxifen is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer Estrogen receptor[1] References [1]. Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998 Nov 26;339(22):1609-18. [2]. Hawariah A, et al. In vitro response of human breast cancer cell lines to the growth-inhibitory effects of styrylpyrone derivative (SPD) and assessment of its antiestrogenicity. Anticancer Res. 1998 Nov-Dec;18(6A):4383-6. [3]. Jia Y, et al. Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal DilatedCardiomyopathy in Mice. PLoS One. 2016 Aug 22;11(8):e0160755. [4]. Wang Y, et al. Evaluation of the safety and tolerability of tamoxifen for ischemia-incited renal injury in mice. Am J Transl Res. 2018 Jul 15;10(7):2184-2194. eCollection 2018. Chemical & Physical Properties Molecular Formula C26H29NO Exact Mass 371.224915 PSA 12.47000 Index of Refraction 1.582 InChIKey NKANXQFJJICGDU-QPLCGJKRSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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