CAS Number32004-67-4
SynonymsMFCD00869764; {(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfanyl)benzylidene]-1H-inden-3-yl}acetic acid; (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid; EINECS 250-892-2; SULINDAC SULFIDE; 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)inden-3-ylacetic acid ; [Sulindac Sulfide ]; 5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid
Molecular FormulaC20H17FO2S
Molecular Weight340.41
Purity≥98 (TLC)%
Density1.3±0.1 g/cm3
Boiling Point526.3±50.0 °C at 760 mmHg
Melting Point189-191°C
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 32004-67-4 |
| Catalog No. | 2A-9012534 |
| Chinese Name | 5-氟-2-甲基-1-(4-甲硫基亚苄基)茚-3-乙酸 |
| Synonyms | MFCD00869764; {(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfanyl)benzylidene]-1H-inden-3-yl}acetic acid; (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid; EINECS 250-892-2; SULINDAC SULFIDE; 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)inden-3-ylacetic acid ; [Sulindac Sulfide ]; 5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid |
| Molecular Formula | C20H17FO2S |
| Molecular Weight | 340.41 |
| Purity | ≥98 (TLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 526.3±50.0 °C at 760 mmHg |
| Melting Point | 189-191°C |
| Appearance | solid |
| Water Solubility | DMSO: >22 mg/mL |
| Storage Condition | Keep the receptacle sealed, stored in a cool, dry |
| Application | (E/Z)-Sulindac sulfide is a potent gamma-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-sulindac sulfide can be used to stu |
| MDL Number | MFCD00869764 |
| SMILES | Fc1cc2c(cc1)\C(=C\c3ccc(cc3)SC)\C(=C2CC(=O)O)C |
| InChI | 1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9+ |
| InChI Key | LFWHFZJPXXOYNR-RQZCQDPDSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| Hazard Symbols | Transport |
| MSDS | msds/12534_1_32004_67_4.pdf |
| Bioactivity | (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease[1]. Related Catalog Research Areas >> Neurological Disease Target γ-secretase, Amyloid-β[1] References [1]. Richter L, et al. Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 526.3±50.0 °C at 760 mmHg Melting Point 189-191°C Molecular Formula C20H17FO2S Molecular Weight 340.411 Flash Point 272.1±30.1 °C Exact Mass 340.093323 PSA 62.60000 LogP 5.74 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.653 InChIKey LFWHFZJPXXOYNR-RQZCQDPDSA-N SMILES CSc1ccc(C=C2C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 Water Solubility DMSO: >22 mg/mL |
| Use of | (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease[1]. Properties Articles45 Name Sulindac sulfide Synonym More Synonyms Sulindac Sulfide Biological Activity Description (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease[1]. Related Catalog Research Areas >> Neurological Disease γ-secretase, Amyloid-β[1] References [1]. Richter L, et al. Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602. Chemical & Physical Properties Molecular Formula C20H17FO2S Exact Mass 340.093323 PSA 62.60000 Index of Refraction 1.653 InChIKey LFWHFZJPXXOYNR-RQZCQDPDSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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