CAS Number3056-17-5
Synonyms1-(2,3-Dideoxy-Beta-D-Glycero-2-Pentenofuranosyl)Thymine; Sanilvudine; Virostav; 1-[(2R,5S)-5-(Hydroxymethyl)-2,5-dihydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; 4-Hydroxy-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydro-2-furanyl]-5-methyl-2(1H)-pyrimidinone; Stavudine; Stauvidine; 3'-Deoxy-2'-thymidinene; 1-(2,3-Dideoxy-β-D-glycero-2-pentenofuranosyl)thymine; Zerit; 1-[(2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidin-2,4(1H,3H)-dion; 2',3'-dideoxy-2',3'-didehydrothymidine; 1-[(2R,5S)-5-(hydroxyméthyl)-2,5-dihydrofuran-2-yl]-5-méthylpyrimidine-2,4(1H,3H)-dione; 2',3'-didehydro-3'-deoxythimidine; 1-(2,3-Dideoxy-b-glycero-pent-2-enofuranosyl)thymine; D 4T; D4T; estavudina; MFCD00132921; 2',3'-Anhydrothymidine; Stavir; Avostav; Sanilvudine (JAN); 1-[(2R,5S)-5-(hydroxymethyl
Molecular FormulaC10H12N2O4
Molecular Weight224.21
Purity≥98 (TLC)%
Density1.5±0.1 g/cm3
Boiling Point440.6±55.0 °C at 760 mmHg
Melting Point159-160°C
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3056-17-5 |
| Catalog No. | 2A-9012507 |
| Chinese Name | 司他夫定 |
| Synonyms | 1-(2,3-Dideoxy-Beta-D-Glycero-2-Pentenofuranosyl)Thymine; Sanilvudine; Virostav; 1-[(2R,5S)-5-(Hydroxymethyl)-2,5-dihydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; 4-Hydroxy-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydro-2-furanyl]-5-methyl-2(1H)-pyrimidinone; Stavudine; Stauvidine; 3'-Deoxy-2'-thymidinene; 1-(2,3-Dideoxy-β-D-glycero-2-pentenofuranosyl)thymine; Zerit; 1-[(2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidin-2,4(1H,3H)-dion; 2',3'-dideoxy-2',3'-didehydrothymidine; 1-[(2R,5S)-5-(hydroxyméthyl)-2,5-dihydrofuran-2-yl]-5-méthylpyrimidine-2,4(1H,3H)-dione; 2',3'-didehydro-3'-deoxythimidine; 1-(2,3-Dideoxy-b-glycero-pent-2-enofuranosyl)thymine; D 4T; D4T; estavudina; MFCD00132921; 2',3'-Anhydrothymidine; Stavir; Avostav; Sanilvudine (JAN); 1-[(2R,5S)-5-(hydroxymethyl |
| Molecular Formula | C10H12N2O4 |
| Molecular Weight | 224.21 |
| Purity | ≥98 (TLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 440.6±55.0 °C at 760 mmHg |
| Melting Point | 159-160°C |
| Appearance | powder |
| Water Solubility | 5-10 g/100 mL at 21 ºC |
| Storage Condition | Sealed in a cool, dry environment at -20 ºC |
| Application | Stavudine is a nucleoside analog that inhibits HIV reverse transcriptase. |
| HTC | 2938901000 |
| PubChem ID | 24278356 |
| MDL Number | MFCD00132921 |
| SMILES | CC1=CN([C@@H]2O[C@H](CO)C=C2)C(=O)NC1=O |
| InChI | 1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1 |
| InChI Key | XNKLLVCARDGLGL-JGVFFNPUSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/12507_1_3056_17_5.pdf |
| Bioactivity | Stavudine is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.Target: HIV RT; NRTIsStavudine is a dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. Stavudine is an analog of thymidine. It is phosphorylated by cellular kinases into active triphosphate. Stavudine triphosphate inhibits the HIV reverse transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termination of DNA synthesis by incorporating into it [1]. Mice were treated for 2 weeks with stavudine d4T (500 mg/kg/day), L-carnitine (200 mg/kg/day) or both drugs concomitantly. Body fatness was assessed by dual energy X-ray absorptiometry, and investigations were performed in plasma, liver, muscle and WAT. D4T reduced the gain of body adiposity, WAT leptin, whole body FAO and plasma ketone bodies, and increased liver triglycerides and plasma aminotransferases with mild ultrastructural abnormalities in hepatocytes [2].Clinical indications: HIV-1 infection FDA Approved Date: June 24, 1994 Toxicity: peripheral neuropathy; lipodystrophy Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection References [1]. Lea AP, et al. Stavudine: a review of its pharmacodynamic and pharmacokinetic properties and clinical potential in HIV infection. Drugs. 1996 May;51(5):846-64. [2]. Igoudjil A, et al. High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice. Antivir Ther. 2007;12(3):389-400. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 440.6±55.0 °C at 760 mmHg Melting Point 159-160°C Molecular Formula C10H12N2O4 Molecular Weight 224.213 Flash Point 220.3±31.5 °C Exact Mass 224.079712 PSA 84.32000 LogP -1.25 Vapour Pressure 0.0±2.4 mmHg at 25°C Index of Refraction 1.646 InChIKey XNKLLVCARDGLGL-JGVFFNPUSA-N SMILES Cc1cn(C2C=CC(CO)O2)c(=O)[nH]c1=O Storage condition −20°C Stability Stable. Combustible. Incompatible with strong oxidizing agents. Water Solubility 5-10 g/100 mL at 21 ºC |
| Use of | Properties Articles62 Name stavudine Synonym More Synonyms Stavudine Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection References [1]. Lea AP, et al. Stavudine: a review of its pharmacodynamic and pharmacokinetic properties and clinical potential in HIV infection. Drugs. 1996 May;51(5):846-64. [2]. Igoudjil A, et al. High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice. Antivir Ther. 2007;12(3):389-400. Chemical & Physical Properties Molecular Formula C10H12N2O4 Exact Mass 224.079712 PSA 84.32000 LogP -1.25 Index of Refraction 1.646 InChIKey XNKLLVCARDGLGL-JGVFFNPUSA-N Stability Stable. Combustible. Incompatible with strong oxidizing agents. |
| Tax Rebate | 13.0% |
| Supervision | None. Minimum tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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