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Silver sulfadiazine structure, CAS 22199-08-2

Silver sulfadiazine

CAS Number22199-08-2

SynonymsBenzenesulfonamide, 4-amino-N-2-pyrimidinyl-, silver(1+) salt (1:1); MFCD00072101; Silber(1+)-[(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanid; silver sulphadiazine; Silver(I) sulfadiazine; Flammazine; FLAMAZINE; Silvadene; SULFADIAZINE SILVER; Sulfanilsaeure-pyrimidin-2-ylamid,Silber(I)-Salz; silver sulfadiazinate; Dermazin; Silverol; Thermazene; benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, monosilver(1+) salt; Sulfadiazine, silver (USP); Sulfadiazine silver salt; Silver(I) sulfadiazine,Sulfadiazine silver; Silver sulfadiazine; Silver(1+) [(4-aminophenyl)sulfonyl](2-pyrimidinyl)azanide; silver,(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide; 4-amino-N-pyrimidin-2-yl-benzenesulfonamide; sulfanilic acid pyrimidin-2-ylamide,silver (I)-salt; Sulfadiazine, Silver; Silver(1+) [(4-aminophenyl)sulf

Molecular FormulaC10H9AgN4O2S

Molecular Weight357.14

Purity98%

Density1.496g/cm3

Boiling Point512.6ºC at 760 mmHg

Melting Point285 °C (dec.) (lit.)

Flash Point

Appearancepowder

EINECS244-834-5

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9012444 Purity: 98%
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Quality Control of [ 22199-08-2 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number22199-08-2
Catalog No.2A-9012444
Chinese Name磺胺嘧啶银
SynonymsBenzenesulfonamide, 4-amino-N-2-pyrimidinyl-, silver(1+) salt (1:1); MFCD00072101; Silber(1+)-[(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanid; silver sulphadiazine; Silver(I) sulfadiazine; Flammazine; FLAMAZINE; Silvadene; SULFADIAZINE SILVER; Sulfanilsaeure-pyrimidin-2-ylamid,Silber(I)-Salz; silver sulfadiazinate; Dermazin; Silverol; Thermazene; benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, monosilver(1+) salt; Sulfadiazine, silver (USP); Sulfadiazine silver salt; Silver(I) sulfadiazine,Sulfadiazine silver; Silver sulfadiazine; Silver(1+) [(4-aminophenyl)sulfonyl](2-pyrimidinyl)azanide; silver,(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide; 4-amino-N-pyrimidin-2-yl-benzenesulfonamide; sulfanilic acid pyrimidin-2-ylamide,silver (I)-salt; Sulfadiazine, Silver; Silver(1+) [(4-aminophenyl)sulf
Molecular FormulaC10H9AgN4O2S
Molecular Weight357.14
Purity98
Density1.496g/cm3
Boiling Point512.6ºC at 760 mmHg
Melting Point285 °C (dec.) (lit.)
Appearancepowder
ApplicationSilver sulfadiazine (AgSD) is a sulfonamide antibiotic. The sulfonamide moiety (SD-SDZ) exerts a dual inhibitory effect on bacterial growth, preventing bacterial folic acid absorption and subsequent D
EINECS244-834-5
HTC2935001000
PubChem ID24871745
MDL NumberMFCD00072101
SMILESNc1ccc(cc1)S(=O)(=O)N([Ag])c2ncccn2
InChI1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1
InChI KeyUEJSSZHHYBHCEL-UHFFFAOYSA-N
NACRES CodeNA.23
UNSPSC12352302
MSDSmsds/12444_1_22199_08_2.pdf
BioactivitySilver sulfadiazine (AgSD), a sulfonamide antibiotic, effects a dual inhibitory action on bacterial growth by its sulfa moiety (SD-SDZ) that prevents bacterial folate absorption and subsequent DNA synthesis. The silver that is released from Silver sulfadiazine binds and disrupts the DNA structure, precluding bacterial DNA replication[1]. Related Catalog Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial In Vitro Silver sulfadiazine (AgSD) is a topical antibiotic used to the research of bacterial infection in burns[2]. References [1]. Strydom SJ, et al. Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity. Nanomedicine. 2013;9(1):85-93. [2]. Munhoz DR, et al. Alginate films functionalized with silver sulfadiazine-loaded [Mg-Al] layered double hydroxide as antimicrobial wound dressing. Int J Biol Macromol. 2019;141:504-510. Chemical & Physical Properties Density 1.496g/cm3 Boiling Point 512.6ºC at 760 mmHg Melting Point 285 °C (dec.)(lit.) Molecular Formula C10H9AgN4O2S Molecular Weight 357.137 Flash Point 263.8ºC Exact Mass 355.949707 PSA 94.32000 LogP 3.11490 Vapour Pressure 1.28E-10mmHg at 25°C InChIKey UEJSSZHHYBHCEL-UHFFFAOYSA-N SMILES Nc1ccc(S(=O)(=O)[N-]c2ncccn2)cc1.[Ag+] Storage condition Hygroscopic, Refrigerator, Under Inert Atmosphere Stability Stable. Incompatible with strong oxidizing agents.
Use ofProperties Name silver(1+) sulfadiazinate Synonym More Synonyms Silver sulfadiazine Biological Activity Related Catalog Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial In Vitro Silver sulfadiazine (AgSD) is a topical antibiotic used to the research of bacterial infection in burns[2]. References [1]. Strydom SJ, et al. Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity. Nanomedicine. 2013;9(1):85-93. [2]. Munhoz DR, et al. Alginate films functionalized with silver sulfadiazine-loaded [Mg-Al] layered double hydroxide as antimicrobial wound dressing. Int J Biol Macromol. 2019;141:504-510. Chemical & Physical Properties Molecular Formula C10H9AgN4O2S Exact Mass 355.949707 PSA 94.32000 LogP 3.11490 InChIKey UEJSSZHHYBHCEL-UHFFFAOYSA-N Storage condition Hygroscopic, Refrigerator, Under Inert Atmosphere Stability Stable. Incompatible with strong oxidizing agents.
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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