CAS Number671-16-9
Synonyms4-[(2-methylhydrazinyl)methyl]-N-(propan-2-yl)benzamide; Natulan; Procarbazine; N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide; N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide; Procarbazina; [4-(2-methyl-hydrazino)-methyl-benzoic acid-isopropylamide]; Procarbazinum; Ibenzmethyzin; EINECS 211-582-2; MFCD00866411; N-Isopropyl-4-((2-methylhydrazinyl)methyl)benzamide; 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide; Procarbazin; N-isopropyl-4-[(N'-methylhydrazino)methyl]benzamide
Molecular FormulaC12H19N3O
Molecular Weight257.76
Purity≥98 (HPLC)%
Density1.0±0.1 g/cm3
Boiling Point384.6±35.0 °C at 760 mmHg
Appearancepowder
EINECS206-678-6
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 671-16-9 |
| Catalog No. | 2A-9012132 |
| Chinese Name | 甲基苄肼 |
| Synonyms | 4-[(2-methylhydrazinyl)methyl]-N-(propan-2-yl)benzamide; Natulan; Procarbazine; N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide; N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide; Procarbazina; [4-(2-methyl-hydrazino)-methyl-benzoic acid-isopropylamide]; Procarbazinum; Ibenzmethyzin; EINECS 211-582-2; MFCD00866411; N-Isopropyl-4-((2-methylhydrazinyl)methyl)benzamide; 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide; Procarbazin; N-isopropyl-4-[(N'-methylhydrazino)methyl]benzamide |
| Molecular Formula | C12H19N3O |
| Molecular Weight | 257.76 |
| Purity | ≥98 (HPLC) |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 384.6±35.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | 20°C, inert gas, protected from light |
| Application | Procarbazine is an orally active alkylating agent with anticancer activity. Procarbazine can be used in the research of Hodgkin's disease [1][2]. |
| EINECS | 206-678-6 |
| HTC | 2928000090 |
| PubChem ID | 329825106 |
| MDL Number | MFCD00072082 |
| SMILES | Cl.CNNCc1ccc(cc1)C(=O)NC(C)C |
| InChI | 1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H |
| InChI Key | DERJYEZSLHIUKF-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/12132_1_671_16_9.pdf |
| Use of | Procarbazine is an orally active alkylating agent, with anticancer activity. Procarbazine can be used in Hodgkin's disease research[1][2]. Properties Name procarbazine Synonym More Synonyms Procarbazine Biological Activity Description Procarbazine is an orally active alkylating agent, with anticancer activity. Procarbazine can be used in Hodgkin's disease research[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker References [1]. J M Erikson, et al. Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells. Cancer Res. 1989 Jan 1;49(1):127-33. [2]. T Suzuki, et al. Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations. Mutat Res. 1999 Aug 18;444(2):269-81. Chemical & Physical Properties Molecular Formula C12H19N3O Exact Mass 221.152817 PSA 53.16000 Index of Refraction 1.529 InChIKey CPTBDICYNRMXFX-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : p-Toluamide, N-isopropyl-alpha-(2-methylhydrazino)- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C12-H19-N3-O MOLECULAR WEIGHT : WISWESSER LINE NOTATION : 1Y1&MVR D1MM1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - Kidney tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Brain and Coverings - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Primate - monkey DOSE/DURATION : TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 12 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - gastrointestinal system Reproductive - Specific Developmental Abnormalities - homeostasis TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 12 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - urogenital system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 3 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : male 1-5 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : male 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intratesticular SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : female 16 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SEX/DURATION : female 12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - delayed effects TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : male 5 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : male 5 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct TYPE OF TEST : Specific locus test TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Sex chromosome loss and nondisjunction TYPE OF TEST : Sex chromosome loss and nondisjunction TYPE OF TEST : Dominant lethal test TYPE OF TEST : Specific locus test TYPE OF TEST : Morphological transformation TYPE OF TEST : DNA damage TYPE OF TEST : DNA damage TYPE OF TEST : DNA damage TYPE OF TEST : DNA inhibition TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Sperm Morphology TYPE OF TEST : Micronucleus test TYPE OF TEST : Micronucleus test TYPE OF TEST : Micronucleus test TYPE OF TEST : Specific locus test TYPE OF TEST : Specific locus test TYPE OF TEST : Specific locus test TYPE OF TEST : Specific locus test TYPE OF TEST : Specific locus test TYPE OF TEST : Unscheduled DNA synthesis TYPE OF TEST : Mutation test systems - not otherwise specified TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Sister chromatid exchange TYPE OF TEST : Dominant lethal test TYPE OF TEST : Dominant lethal test TYPE OF TEST : Dominant lethal test TYPE OF TEST : Sperm Morphology TYPE OF TEST : Sperm Morphology TYPE OF TEST : Sister chromatid exchange TYPE OF TEST : Sister chromatid exchange TYPE OF TEST : Sister chromatid exchange MUTATION DATA TEST SYSTEM : Rodent - rabbit DOSE/DURATION : REFERENCE : Safety Information Hazard Codes Xn HS Code 2928000090 Synthetic Route 4-[(2-methyl-1,... CAS#:58914-41-3 Procarbazine CAS#:671-16-9 Literature: CH441366 , ; Chem.Abstr., , vol. 69, # 35691 methyl p-toluate CAS#:99-75-2 Procarbazine CAS#:671-16-9 Literature: CH441366 , ; Chem.Abstr., , vol. 69, # 35691 1-[(4-Carboxyph... CAS#:18969-60-3 Procarbazine CAS#:671-16-9 Literature: CH441366 , ; Chem.Abstr., , vol. 69, # 35691 Precursor & DownStream Precursor 4 CAS#:58914-41-3 4-[(2-methyl-1,... CAS#:99-75-2 methyl p-toluate CAS#:18969-60-3 1-[(4-Carboxyph... CAS#:2417-72-3 Methyl 4-(bromo... DownStream 2 CAS#:13255-50-0 4-Formyl-N-isop... CAS#:144464-32-4 4-(N-Methyl-N-n... |
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| Transport Info | Product name: Summary 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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