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Prochloraz structure, CAS 67747-09-5

Prochloraz

CAS Number67747-09-5

SynonymsProchloraz; Abarit; MASTER; EINECS 266-994-5; octave; N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide; FORTAK; sprint; T5N CNJ AVN3&2OR BG DG FG; EYETAK; MFCD00078735; P-242; prochloraz [ANSI]; KI 835; N-Propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide; MIRAGE; ascurit; 1-[N-Propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]carbamoyl]imidazole

Molecular FormulaC15H16Cl3N3O2

Molecular Weight376.67

Purity97%

Density1.4±0.1 g/cm3

Boiling Point499.8±55.0 °C at 760 mmHg

Melting Point46-49°C

Flash Point

Appearancecolorless solid

EINECS266-994-5

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9012137 Purity: 97%
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Quality Control of [ 67747-09-5 ] Purity: 97% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number67747-09-5
Catalog No.2A-9012137
Chinese Name咪鲜安
SynonymsProchloraz; Abarit; MASTER; EINECS 266-994-5; octave; N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide; FORTAK; sprint; T5N CNJ AVN3&2OR BG DG FG; EYETAK; MFCD00078735; P-242; prochloraz [ANSI]; KI 835; N-Propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide; MIRAGE; ascurit; 1-[N-Propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]carbamoyl]imidazole
Molecular FormulaC15H16Cl3N3O2
Molecular Weight376.67
Purity97
Density1.4±0.1 g/cm3
Boiling Point499.8±55.0 °C at 760 mmHg
Melting Point46-49°C
Appearancecolorless solid
Storage ConditionStore in a sealed container in a cool, dry place.
PackagingIII
ApplicationProchloraz is an imidazole antifungal drug that inhibits ergosterol biosynthesis by inhibiting cytochrome P450-dependent crosterol 14α-demethylation, leading to fungal cell membrane rupture and cell d
EINECS266-994-5
HTC2933290012
PubChem ID329756845
MDL NumberMFCD00078735
SMILESCCCN(CCOc1c(Cl)cc(Cl)cc1Cl)C(=O)n2ccnc2
InChI1S/C15H16Cl3N3O2/c1-2-4-20(15(22)21-5-3-19-10-21)6-7-23-14-12(17)8-11(16)9-13(14)18/h3,5,8-10H,2,4,6-7H2,1H3
InChI KeyTVLSRXXIMLFWEO-UHFFFAOYSA-N
Beilstein/REAXYS8155344
NACRES CodeNA.24
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/12137_1_67747_09_5.pdf
BioactivityProchloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Prochloraz inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 μM and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM). Related Catalog Signaling Pathways >> Others >> Estrogen Receptor/ERR Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor Signaling Pathways >> Others >> Androgen Receptor Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 499.8±55.0 °C at 760 mmHg Melting Point 46-49°C Molecular Formula C15H16Cl3N3O2 Molecular Weight 376.665 Flash Point 256.1±31.5 °C Exact Mass 375.030823 PSA 47.36000 LogP 3.98 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.597 InChIKey TVLSRXXIMLFWEO-UHFFFAOYSA-N SMILES CCCN(CCOc1c(Cl)cc(Cl)cc1Cl)C(=O)n1ccnc1
Use ofProchloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Prochloraz inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 μM and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM). Properties Articles31 Name prochloraz Synonym More Synonyms prochloraz Biological Activity Description Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Prochloraz inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 μM and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM). Related Catalog Signaling Pathways >> Others >> Estrogen Receptor/ERR Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor Signaling Pathways >> Others >> Androgen Receptor Chemical & Physical Properties Exact Mass 375.030823 PSA 47.36000 Index of Refraction 1.597 InChIKey TVLSRXXIMLFWEO-UHFFFAOYSA-N
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Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3077 International Maritime Transport Danger Regulations: 3077 International Air Transport Danger Regulations: 3077 14.2 United Nations shipping name European land transport hazard regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Prochloraz) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Prochloraz) International air transport hazard regulations: Environmentally hazardous substance, solid, n.o.s. (Prochloraz) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations International Air Transport Dangerous Regulations: Yes Marine Pollutants (Yes/No): Yes 14.6 Special reminder to users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3),
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