CAS Number92-62-6
Synonyms3,6-Diamino-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile; 3,6-Diamino-5-cyan-1-methyl-1H-pyrazolo<3,4-b>pyridin; acridine-3,6-diamine; 3,6-Acridinediamine
Molecular FormulaC13H11N3
Molecular Weight209.25
Purity98.00%
Density1.346 g/cm3
Boiling Point506.9ºC at 760 mmHg
Melting Point260ºC
AppearanceOrange to brown powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 92-62-6 |
| Catalog No. | 2A-9012141 |
| Chinese Name | 吖啶-3,6-二胺 |
| Synonyms | 3,6-Diamino-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile; 3,6-Diamino-5-cyan-1-methyl-1H-pyrazolo<3,4-b>pyridin; acridine-3,6-diamine; 3,6-Acridinediamine |
| Molecular Formula | C13H11N3 |
| Molecular Weight | 209.25 |
| Purity | 98.00 |
| Density | 1.346 g/cm3 |
| Boiling Point | 506.9ºC at 760 mmHg |
| Melting Point | 260ºC |
| Appearance | Orange to brown powder |
| Water Solubility | Water solubility: soluble; soluble in: ethanol, di |
| Storage Condition | Store in inert gas; avoid air |
| Application | Alanine is an acridine dye and a known DNA intercalating agent. Antibacterial agents[1]. Prorafine acts as a pore blocker on Kir3. 2.Alanine is a potential lead compound of Kir3. 2-Related neurologica |
| HTC | 2933990090 |
| MDL Number | MFCD00005030 |
| SMILES | Nc1ccc2cc3ccc(N)cc3nc2c1 |
| InChI | InChI=1S/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2 |
| InChI Key | WDVSHHCDHLJJJR-UHFFFAOYSA-N |
| MSDS | msds/12141_1_92_62_6.pdf |
| Use of | Proflavine, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine behaves as a pore blocker for Kir3.2. Proflavine is a potential lead compound for Kir3.2-associated neurological diseases[2]. Properties Name 3,6-diaminoacridine Synonym More Synonyms Proflavine Biological Activity Description Proflavine, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine behaves as a pore blocker for Kir3.2. Proflavine is a potential lead compound for Kir3.2-associated neurological diseases[2]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Anti-infection >> Bacterial References [1]. Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3(4): 272-278. [2]. Hitoshi Kawada, et al. Isolation of proflavine as a blocker of G protein-gated inward rectifier potassium channels by a cell growth-based screening system. Neuropharmacology. 2016 Oct;109:18-28. [3]. Jiaxin Chen, et al. Determination of proflavine in rat whole blood without sample pretreatment by laser desorption postionization mass spectrometry. Anal Bioanal Chem. 2017 Apr;409(11):2813-2819. Chemical & Physical Properties Molecular Formula C13H11N3 Exact Mass 209.09500 PSA 64.93000 LogP 3.71480 Index of Refraction 1.833 InChIKey WDVSHHCDHLJJJR-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Acridine, 3,6-diamino- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C13-H11-N3 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T C666 BNJ EZ MZ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 11111 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes TYPE OF TEST : Specific locus test TYPE OF TEST : DNA inhibition MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 13500 nmol/L REFERENCE : ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 67,127,1965 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6466 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 621 (estimated) Safety Information HS Code 2933990090 Synthetic Route Proflavine hydr... Proflavine Benzenamine,4,4... 26946-33-8 Proflavine m-Phenylenediam... Proflavine Literature: Journal of the Chemical Society, , p. 121,484 DE347819 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 799 Precursor & DownStream Precursor 8 CAS#:952-23-8 Proflavine hydr... CAS#:26946-33-8 Benzenamine,4,4... CAS#:108-45-2 m-Phenylenediamine CAS#:101-22-4 N,N'-bis(3-amin... DownStream 7 CAS#:15724-70-6 Acetamide,N,N'-... CAS#:113110-49-9 N-[6-[(4-methyl... CAS#:74165-99-4 N-(6-aminoacrid... CAS#:103900-67-0 3,6-dihydroxy-4... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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