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Procaterol structure, CAS 72332-33-3

Procaterol

CAS Number72332-33-3

Synonyms8-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1h)-quinolinone(r*,s; EINECS 276-590-0; s*)-(+-); PROCATEROL; ent-Florfenicol AMine-d3; (S)-N,N-DiMethyl-3-(1-naphthalenyl-d7-oxy)-3-(2-thienyl)propanaMine; MFCD01750015

Molecular FormulaC16H22N2O3

Molecular Weight290.36

Purity98%

Density1.191 g/cm3

Boiling Point539.5ºC at 760 mmHg

Melting Point170-173 °C(lit.)

Flash Point

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EINECS

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Cat. No.: 2A-9012134 Purity: 98%
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Quality Control of [ 72332-33-3 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number72332-33-3
Catalog No.2A-9012134
Chinese Name5-(1-羟基-2-异丙胺基丁基)-8-羧基喹诺酮
Synonyms8-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1h)-quinolinone(r*,s; EINECS 276-590-0; s*)-(+-); PROCATEROL; ent-Florfenicol AMine-d3; (S)-N,N-DiMethyl-3-(1-naphthalenyl-d7-oxy)-3-(2-thienyl)propanaMine; MFCD01750015
Molecular FormulaC16H22N2O3
Molecular Weight290.36
Purity98
Density1.191 g/cm3
Boiling Point539.5ºC at 760 mmHg
Melting Point170-173 °C(lit.)
Water Solubility3000 g/L (20 ºC)
Storage Condition-20°C
ApplicationProcaterol is an oral selective beta2-adrenoceptor agonist. Procaterol inhibits eosinophil migration and eotaxin release from BEAS-2B cells via a cyclic AMP-dependent mechanism. There is a large dose
HTC29211190
SMILESCCC(NC(C)C)C(O)c1ccc(O)c2[nH]c(=O)ccc12
InChIInChI=1S/C16H22N2O3.ClH/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15;/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20);1H/t12-,16+;/m0./s1
InChI KeyFKNXQNWAXFXVNW-BLLLJJGKSA-N
Use ofProcaterol is an oral selective β2 adrenergic receptor agonist. Procaterol inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism. Procaterol has a large dose difference existing between the bronchodilator effect and the anabolic effect in rat, can be used for asthma research in athletes[1]. Properties Name (R*,S*)-(-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone Synonym More Synonyms Procaterol Biological Activity Description Procaterol is an oral selective β2 adrenergic receptor agonist. Procaterol inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism. Procaterol has a large dose difference existing between the bronchodilator effect and the anabolic effect in rat, can be used for asthma research in athletes[1]. Related Catalog Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor β2 adrenoceptor References [1]. Ikezono K, et al. Bronchodilating effect and anabolic effect of inhaled procaterol. Int J Sports Med. 2008 Nov;29(11):888-94. [2]. Tashimo H, et al. Effect of procaterol, a beta(2) selective adrenergic receptor agonist, on airway inflammation and hyperresponsiveness. Allergol Int. 2007 Sep;56(3):241-7. [3]. Koyama S, et al. Procaterol inhibits IL-1beta- and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity. Eur Respir J. 1999 Oct;14(4):767-75. [4]. Yamaya M, et al. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011 Jan 10;650(1):431-44. [5]. Komatani-Tamiya N, et al. Procaterol-stimulated increases in ciliary bend amplitude and ciliary beat frequency in mouse bronchioles. Cell Physiol Biochem. 2012;29(3-4):511-22. Chemical & Physical Properties Molecular Formula C16H22N2O3 Exact Mass 290.16300 PSA 85.35000 LogP 2.43460 InChIKey FKNXQNWAXFXVNW-BLLLJJGKSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2(1H)-Quinolinone, 8-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl) -, (R*,S*)-(+-)- CAS REGISTRY NUMBER : 72332-33-3 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C16-H22-N2-O3 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SYXUE3 Shenyang Yaoxueyuan Xuebao. Journal of Shenyang College of Pharmacy. (Shenyang Yaoxueyuan, 7, 2-duan, Wenhualu, Shenhequ, Shenyang, Peop. Rep. China) V.1- 1984- Volume(issue)/page/year: 3,259,1986 Safety Information Hazard Codes Xn WGK Germany 1 RTECS IQ0220000 HS Code 29211190
Transport InfoProduct Name: Procaterol
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