CAS Number62-68-0
SynonymsBenzeneacetic acid, α-phenyl-α-propyl-, 2-(diethylamino)ethyl ester, hydrochloride (1:1); 2-Diethylaminoethyl Propyldiphenylacetate Hydrochloride; β-Diethylaminoethyl diphenylpropylacetate hydrochloride; F 525-A; SKF-525A,Hydrochloride; RP 5171; 2-Diethylaminoethyl α,α-diphenyl valerate hydrochloride; 2,2-Diphenylvaleric Acid 2-(Diethylamino)ethyl Ester Hydrochloride; 2-[(2,2-diphenylpentanoyl)oxy]-N,N-diethylethanaminium chloride; Benzeneacetic acid, α-phenyl-α-propyl-, 2- (diethylamino)ethyl ester, hydrochloride; Proadifen HCl; Proadifen hydrochloride; proadifen; 2-Diethylaminoethyl-2,2-diphenylvalerate Hydrochloride; N,N-diethylaminoethyl-2,2-diphenylvalerate hydrochloride; Valeric acid, 2,2-diphenyl-, 2-diethylaminoethyl ester, hydrochloride; SKF 525A; Valeric acid, 2,2-diphenyl-, 2- (
Molecular FormulaC23H32ClNO2
Molecular Weight389.96
Purity≥95%
Boiling Point460.8ºC at 760 mmHg
Melting Point122-123 °C
Appearancewhite solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 62-68-0 |
| Catalog No. | 2A-9012126 |
| Chinese Name | 普罗地芬 盐酸盐 |
| Synonyms | Benzeneacetic acid, α-phenyl-α-propyl-, 2-(diethylamino)ethyl ester, hydrochloride (1:1); 2-Diethylaminoethyl Propyldiphenylacetate Hydrochloride; β-Diethylaminoethyl diphenylpropylacetate hydrochloride; F 525-A; SKF-525A,Hydrochloride; RP 5171; 2-Diethylaminoethyl α,α-diphenyl valerate hydrochloride; 2,2-Diphenylvaleric Acid 2-(Diethylamino)ethyl Ester Hydrochloride; 2-[(2,2-diphenylpentanoyl)oxy]-N,N-diethylethanaminium chloride; Benzeneacetic acid, α-phenyl-α-propyl-, 2- (diethylamino)ethyl ester, hydrochloride; Proadifen HCl; Proadifen hydrochloride; proadifen; 2-Diethylaminoethyl-2,2-diphenylvalerate Hydrochloride; N,N-diethylaminoethyl-2,2-diphenylvalerate hydrochloride; Valeric acid, 2,2-diphenyl-, 2-diethylaminoethyl ester, hydrochloride; SKF 525A; Valeric acid, 2,2-diphenyl-, 2- ( |
| Molecular Formula | C23H32ClNO2 |
| Molecular Weight | 389.96 |
| Purity | ≥95 |
| Boiling Point | 460.8ºC at 760 mmHg |
| Melting Point | 122-123 °C |
| Appearance | white solid |
| Water Solubility | Soluble in methanol or water |
| Storage Condition | This product should be sealed and stored in a cool |
| Application | Proadifen hydrochloride is a cytochrome P450 inhibitor (IC50 = 19μM). |
| PubChem ID | 329820069 |
| MDL Number | MFCD00055151 |
| SMILES | Cl.CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2 |
| InChI | 1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H |
| InChI Key | FHIKZROVIDCMJA-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/12126_1_62_68_0.pdf |
| Bioactivity | Proadifen hydrochloride is a Cytochrome P450 inhibitor (IC50 = 19μM). IC50 value: 19μMTarget: P450Proadifen HCl has many biochemical functions, some of which include: inhibitory effects on NOS1 (neuronal nitric oxide synthase; IC50 = 90 mM), adult mouse skeletal muscle AChR (acetyl choline receptor), hepatic drug metabolism via the CYP (cytochrome P450) system, CYP-dependent (cytochrome P450-dependent) arachidonate metabolism (90% at 50 μM), transmembrane calcium influx, and platelet thromboxane synthesis. This compound has also been shown to block KIR6.1 (ATP-sensitive inward rectifier potassium channel 8; IC50 = 4.4 mM) and stimulate endothelial cell prostacyclin production. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Others Chemical & Physical Properties Boiling Point 460.8ºC at 760 mmHg Melting Point 122-123ºC Molecular Formula C23H32ClNO2 Molecular Weight 389.959 Flash Point 132.3ºC Exact Mass 389.212158 PSA 29.54000 LogP 5.45980 InChIKey FHIKZROVIDCMJA-UHFFFAOYSA-N SMILES CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c1ccccc1.Cl Storage condition −20°C Stability Store in Freezer Water Solubility Soluble in methanol or water |
| Use of | Properties Articles26 Name 2-(diethylamino)ethyl 2,2-diphenylpentanoate,hydrochloride Synonym More Synonyms Proadifen hydrochloride Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Others Chemical & Physical Properties Exact Mass 389.212158 PSA 29.54000 LogP 5.45980 InChIKey FHIKZROVIDCMJA-UHFFFAOYSA-N Stability Store in Freezer Water Solubility Soluble in methanol or water |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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