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Primidone structure, CAS 125-33-7

Primidone

CAS Number125-33-7

SynonymsPrysoline; Primidon; Mysoline; Misodine; MFCD00038662; Sertan; Primidone; EINECS 204-737-0; 5-ethyl-5-phenyl-dihydro-pyrimidine-4,6-dione; Mylepsinum; Liskantin; Mizodin; 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione; Primaclone; 5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione; 2-Deoxyphenobarbital; 2-Desoxyphenobarbital,5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione

Molecular FormulaC12H14N2O2

Molecular Weight218.25

Purity98%

Density1.138g/cm3

Boiling Point520.7ºC at 760mmHg

Melting Point281-282°C

Flash Point

AppearanceOdorless white crystalline powder, slightly bitter taste, non-acidic

EINECS204-737-0

MSDSChineseEnglish

Symbol6.1(b)

Signal WordWarning

Cat. No.: 2A-9012121 Purity: 98%
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Quality Control of [ 125-33-7 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number125-33-7
Catalog No.2A-9012121
Chinese Name扑米酮
SynonymsPrysoline; Primidon; Mysoline; Misodine; MFCD00038662; Sertan; Primidone; EINECS 204-737-0; 5-ethyl-5-phenyl-dihydro-pyrimidine-4,6-dione; Mylepsinum; Liskantin; Mizodin; 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione; Primaclone; 5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione; 2-Deoxyphenobarbital; 2-Desoxyphenobarbital,5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione
Molecular FormulaC12H14N2O2
Molecular Weight218.25
Purity98
Density1.138g/cm3
Boiling Point520.7ºC at 760mmHg
Melting Point281-282°C
AppearanceOdorless white crystalline powder, slightly bitter taste, non-acidic
Water Solubility<0.1 g/100 mL at 19 ºC
Storage ConditionStorage: sealed and stored.
PackagingIII
ApplicationPrimidone is a GABA receptor inhibitor.
EINECS204-737-0
PubChem ID329820263
MDL NumberMFCD00038662
SMILESCCC1(C(=O)NCNC1=O)c2ccccc2
InChI1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16)
InChI KeyDQMZLTXERSFNPB-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard Symbols6.1(b)
MSDSmsds/12121_1_125_33_7.pdf
BioactivityPrimidone is an anticonvulsant of the pyrimidinedione class.Target: GABA ReceptorPrimidone is an anticonvulsant of the pyrimidinedione class, the active metabolites of which, phenobarbital (minor) and phenylethylmalonamide (PEMA) (major), are also anticonvulsants. It is believed to work via interactions with voltage-gated sodium channels which inhibit high-frequency repetitive firing of action potentials [1]. The effect of primidone in essential tremor is not mediated by PEMA.[76] The major metabolite, phenobarbital, is also a potent anticonvulsant in its own right and likely contributes to primidone's effects in many forms of epilepsy [2]. Primidone and the other enzyme-inducing anticonvulsants can cut the half-life of antipyrine roughly in half (6.2 ± 1.9 h vs. 11.2 ± 4.2 h), and increases the clearance rate by almost 70%. Phenobarbital reduces the half-life to 4.8 ± 1.3 and increases the clearance by almost 109% [3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Macdonald, R.L. and K.M. Kelly, Antiepileptic drug mechanisms of action. Epilepsia, 1995. 36 Suppl 2: p. S2-12. [2]. Calzetti, S., et al., Phenylethylmalonamide in essential tremor. A double-blind controlled study. J Neurol Neurosurg Psychiatry, 1981. 44(10): p. 932-4. [3]. Perucca, E., et al., A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. Br J Clin Pharmacol, 1984. 18(3): p. 401-10. Chemical & Physical Properties Density 1.138g/cm3 Boiling Point 520.7ºC at 760mmHg Melting Point 281-282°C Molecular Formula C12H14N2O2 Molecular Weight 218.25200 Flash Point 228.2ºC Exact Mass 218.10600 PSA 58.20000 LogP 1.19550 Vapour Pressure 6.08E-11mmHg at 25°C Index of Refraction 1.528 InChIKey DQMZLTXERSFNPB-UHFFFAOYSA-N SMILES CCC1(c2ccccc2)C(=O)NCNC1=O Storage condition Store at RT Water Solubility <0.1 g/100 mL at 19 ºC
Use ofProperties Articles37 Name primidone Synonym More Synonyms Primidone Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Macdonald, R.L. and K.M. Kelly, Antiepileptic drug mechanisms of action. Epilepsia, 1995. 36 Suppl 2: p. S2-12. [2]. Calzetti, S., et al., Phenylethylmalonamide in essential tremor. A double-blind controlled study. J Neurol Neurosurg Psychiatry, 1981. 44(10): p. 932-4. [3]. Perucca, E., et al., A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. Br J Clin Pharmacol, 1984. 18(3): p. 401-10. Chemical & Physical Properties Molecular Formula C12H14N2O2 Exact Mass 218.10600 PSA 58.20000 LogP 1.19550 Index of Refraction 1.528 InChIKey DQMZLTXERSFNPB-UHFFFAOYSA-N Storage condition Store at RT
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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