CAS Number63-45-6
Synonyms1,4-pentanediamine, N4-(6-methoxy-8-quinolinyl)-, phosphate (1:2); N4-(6-methoxyquinolin-8-yl)pentane-1,4-diamine phosphate (1:2); N-(6-Methoxy-8-quinolinyl)-1,4-pentanediamine phosphate (1:2); EINECS 200-560-8; Primaquine phosphate; N-(6-Methoxyquinolin-8-yl)pentane-1,4-diamine phosphate (1:2); Primaquine diphosphate; 4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine,phosphoric acid; Primaquine diphosphate salt; 1,4-Pentanediamine, N-(6-methoxy-8-quinolinyl)-, phosphate (1:2); primaquine bis(phosphate); MFCD00013166; Primaquine (Diphosphate)
Molecular FormulaC15H27N3O9P2
Molecular Weight455.337
Purity98%
Boiling Point451.1ºC at 760 mmHg
Melting Point205-206 °C (dec.)(lit.)
Appearanceorange powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 63-45-6 |
| Catalog No. | 2A-9012119 |
| Chinese Name | 磷酸伯安喹 |
| Synonyms | 1,4-pentanediamine, N4-(6-methoxy-8-quinolinyl)-, phosphate (1:2); N4-(6-methoxyquinolin-8-yl)pentane-1,4-diamine phosphate (1:2); N-(6-Methoxy-8-quinolinyl)-1,4-pentanediamine phosphate (1:2); EINECS 200-560-8; Primaquine phosphate; N-(6-Methoxyquinolin-8-yl)pentane-1,4-diamine phosphate (1:2); Primaquine diphosphate; 4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine,phosphoric acid; Primaquine diphosphate salt; 1,4-Pentanediamine, N-(6-methoxy-8-quinolinyl)-, phosphate (1:2); primaquine bis(phosphate); MFCD00013166; Primaquine (Diphosphate) |
| Molecular Formula | C15H27N3O9P2 |
| Molecular Weight | 455.337 |
| Purity | 98 |
| Boiling Point | 451.1ºC at 760 mmHg |
| Melting Point | 205-206 °C (dec.)(lit.) |
| Appearance | orange powder |
| Water Solubility | moderately soluble |
| Storage Condition | This product should be kept sealed. |
| Packaging | III |
| Application | Primaquine is an antimalarial compound. |
| HTC | 2933499090 |
| SMILES | COc1cc(NC(C)CCCN)c2ncccc2c1.O=P(O)(O)O |
| InChI | InChI=1S/C15H21N3O.2H3O4P/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14;2*1-5(2,3)4/h4,6,8-11,18H,3,5,7,16H2,1-2H3;2*(H3,1,2,3,4) |
| InChI Key | RKFFPTPBADAVDU-UHFFFAOYSA-N |
| Hazard Symbols | 6.1(b) |
| Bioactivity | Primaquine is the only generally available anti-malarial that prevents relapse in vivax and ovale malaria, and the only potent gametocytocide in falciparum malaria. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. Ashley EA, et al. Primaquine: the risks and the benefits. Malar J. 2014 Nov 3;13:418. [2]. Rajgor DD, et al. Antirelapse Efficacy of Various Primaquine Regimens for Plasmodium vivax. Malar Res Treat. 2014;2014:347018. [3]. Hanboonkunupakarn B, et al. Open-label crossover study of primaquine and dihydroartemisinin-piperaquine pharmacokinetics in healthy adult thai subjects. Antimicrob Agents Chemother. 2014 Dec;58(12):7340-6. Chemical & Physical Properties Boiling Point 451.1ºC at 760 mmHg Melting Point 205-206 °C (dec.)(lit.) Molecular Formula C15H27N3O9P2 Molecular Weight 455.337 Flash Point 226.6ºC Exact Mass 455.122253 PSA 235.31000 LogP 1.69880 InChIKey RKFFPTPBADAVDU-UHFFFAOYSA-N SMILES COc1cc(NC(C)CCCN)c2ncccc2c1.O=P(O)(O)O Stability Stable. Incompatible with strong oxidizing agents. Water Solubility moderately soluble |
| Use of | Primaquine is the only generally available anti-malarial that prevents relapse in vivax and ovale malaria, and the only potent gametocytocide in falciparum malaria. Properties Articles51 Name Primaquine bisphosphate Synonym More Synonyms primaquine phosphate Biological Activity Description Primaquine is the only generally available anti-malarial that prevents relapse in vivax and ovale malaria, and the only potent gametocytocide in falciparum malaria. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. Ashley EA, et al. Primaquine: the risks and the benefits. Malar J. 2014 Nov 3;13:418. [2]. Rajgor DD, et al. Antirelapse Efficacy of Various Primaquine Regimens for Plasmodium vivax. Malar Res Treat. 2014;2014:347018. [3]. Hanboonkunupakarn B, et al. Open-label crossover study of primaquine and dihydroartemisinin-piperaquine pharmacokinetics in healthy adult thai subjects. Antimicrob Agents Chemother. 2014 Dec;58(12):7340-6. Chemical & Physical Properties Molecular Formula C15H27N3O9P2 Exact Mass 455.122253 PSA 235.31000 LogP 1.69880 InChIKey RKFFPTPBADAVDU-UHFFFAOYSA-N Stability Stable. Incompatible with strong oxidizing agents. Water Solubility moderately soluble |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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