EN
0
Home > Products > Pharmaceuticals & Life Science > API & Advanced Intermediates > Ganciclovir sodium
Ganciclovir sodium structure, CAS 107910-75-8

Ganciclovir sodium

CAS Number107910-75-8

SynonymsSodium 2-amino-9-{[(1,3-dihydroxy-2-propanyl)oxy]methyl}-6-oxo-6,9-dihydropurin-1-ide; Ganciclovir Sodium Salt; sodium 2-amino-9-{[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl}-9h-purin-6-olate; Cymevene; Ganciclovir monosodium salt; 1,3-propanediol, 2-[(2-amino-6-hydroxy-9H-purin-9-yl)methoxy]-, monosodium salt; 2-amino-9-{[2-hydroxy-1-(hydroxyméthyl)éthoxy]méthyl}-9H-purin-6-olate de sodium; Ganciclovir sodium

Molecular FormulaC9H12N5NaO4

Molecular Weight277.212

Purity98%

Density1.81g/cm3

Boiling Point675ºC at 760mmHg

Melting Point250ºC (decomposition)

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9010686 Purity: 98%
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 107910-75-8 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number107910-75-8
Catalog No.2A-9010686
Chinese Name更昔洛韦钠
SynonymsSodium 2-amino-9-{[(1,3-dihydroxy-2-propanyl)oxy]methyl}-6-oxo-6,9-dihydropurin-1-ide; Ganciclovir Sodium Salt; sodium 2-amino-9-{[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl}-9h-purin-6-olate; Cymevene; Ganciclovir monosodium salt; 1,3-propanediol, 2-[(2-amino-6-hydroxy-9H-purin-9-yl)methoxy]-, monosodium salt; 2-amino-9-{[2-hydroxy-1-(hydroxyméthyl)éthoxy]méthyl}-9H-purin-6-olate de sodium; Ganciclovir sodium
Molecular FormulaC9H12N5NaO4
Molecular Weight277.212
Purity98
Density1.81g/cm3
Boiling Point675ºC at 760mmHg
Melting Point250ºC (decomposition)
Appearancepowder
Storage Condition-20℃
ApplicationGanciclovir (BW 759) sodium is a nucleoside analog and oral antiviral drug with antiviral activity against CMV. Ganciclovir sodium also has antiviral activity against herpes viruses (herpes group) and
HTC2933990090
SMILES[Na+].Nc1nc([O-])c2ncn(COC(CO)CO)c2n1
InChIInChI=1S/C9H13N5O4.Na/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16;/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17);/q;+1/p-1
InChI KeyInChIKey=JJICLMJFIKGAAU-UHFFFAOYSA-M
Use ofGanciclovir (BW 759) sodium, a nucleoside analogue and an orally active antiviral agent, shows activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1)[1][2][3]. Properties Name Ganciclovir sodium Synonym More Synonyms Ganciclovir sodium Biological Activity Description Ganciclovir (BW 759) sodium, a nucleoside analogue and an orally active antiviral agent, shows activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1)[1][2][3]. Related Catalog Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Signaling Pathways >> Anti-infection >> CMV FHV-1:5.2 μM (IC50) References [1]. Faulds D, et al. Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections. Drugs. 1990;39(4):597-638. [2]. Maggs DJ, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65(4):399-403. [3]. Boujemla I, et al. Pharmacokinetics and tissue diffusion of ganciclovir in mice and rats. Antiviral Res. 2016;132:111-115. [4]. Fletcher CV, et al. Evaluation of ganciclovir for cytomegalovirus disease. DICP. 1989 Jan;23(1):5-12. [5]. Matthews T, et al. Antiviral activity and mechanism of action of ganciclovir. Rev Infect Dis. 1988 Jul-Aug;10 Suppl 3:S490-4. [6]. Duan J, Paris W, Kibler P, Bousquet C, Liuzzi M, Cordingley MG. Dose and duration-dependence of ganciclovir treatment against murine cytomegalovirus infection in severe combined immunodeficient mice. Antiviral Res. 1998;39(3):189-197. Chemical & Physical Properties Molecular Formula C9H12N5NaO4 Exact Mass 277.078705 PSA 142.37000 Storage condition -20℃ Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 6H-Purin-6-one, 1,9-dihydro-2-amino-9-((2-hydroxy-1-(hydroxymethyl)et hoxy)methyl)-, monosodium salt CAS REGISTRY NUMBER : 107910-75-8 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C9-H12-N5-O4.Na MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 1744 umol/kg/24H (Intermittent) REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 369,65,1996 Safety Information HS Code 2933990090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Related Products in API & Advanced Intermediates
Nystatin1400-61-92A-9010650
Furosemide54-31-92A-9010663
Gabapentin hydrochloride60142-96-32A-0200168
gamma-Lumicolchicine6901-14-02A-9010682
Ganciclovir82410-32-02A-9010685
Gatifloxacin lactate160738-57-82A-9010698
Gefitinib184475-35-22A-9010701
Gemcitabine95058-81-42A-9010704
Gemcitabine hydrochloride122111-03-92A-9010705
Gemifloxacin175463-14-62A-9010708
Browse all API & Advanced Intermediates products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA